Centrum (multivitamin)

Short description: Brand of multivitamins

Centrum

Product type| Multivitamins
Owner| Haleon
Country| United States
Introduced| 1978; 48 years ago (1978)
Previous owners|

* Wyeth
* Pfizer
* GSK

Website| www.centrum.com

Centrum is an American brand of multivitamins produced by Haleon. It was previously owned by Pfizer (formerly Wyeth) and GSK.[1]

Centrum multivitamins in Australasian packaging

## Contents

* 1 Physicians' Health Study II
* 2 Contains
* 2.1 Centrum Mens
* 2.2 Centrum Womens
* 2.3 Centrum Adults
* 3 References
* 4 External links

## Physicians' Health Study II

In 2012, the Physicians' Health Study II (PHS-II) found that participants who took a Centrum-brand multivitamin each day for an average of 11 years had no change in cancer mortality or cardiovascular disease mortality compared to the placebo group. The authors did find a slight reduction in cancer incidence although this conclusion was questioned in the Journal of the American Medical Association.[2]

On October 17, 2012, researchers reported on a double-blind study of 14,641 male U.S. physicians initially aged 50 years or older (mean age of 64.3, standard deviation 9.2 years), that began in 1997 with treatment and follow-up through June 1, 2011. They compared total cancer (excluding nonmelanoma skin cancer) for participants taking a daily multivitamin (Centrum Silver by Pfizer) versus placebo. Compared with placebo, men taking a daily multivitamin had a statistically significant reduction in the incidence of total cancer, with a hazard ratio (HR) = 0.92 (95% confidence interval (CI) 0.86-0.998; P = .04). No statistically significant effects were found for any specific cancers or cancer mortality. The 95% CI of the hazard ratio implied a benefit of between 14% and .2% over placebo. In absolute terms the difference was 1.3 cancer diagnoses, per 1000 years of life (18.3-17 events, respectively). The median follow up time was 11.2 years.[3] The paper's co-principal investigator, Dr. J. Michael Gaziano, a cardiologist, was quoted by The New York Times as saying "it certainly appears there is a modest reduction in the risk of cancer from a typical multivitamin."[4] The study was also featured in The Wall Street Journal on October 17, 2012.[5]

An editorial in the same issue of the Journal of the American Medical Association (JAMA), reflecting the opinion of JAMA, was dismissive of the report on several counts. First, they said, "it seems unlikely that a common characteristic across all diseases included under this wide category of cancer would be a protective effect from multivitamins", suggesting if no specific cancer was effected, why would general cancer risk be so affected. Second, they questioned the study's abilities to deliver on the question of whether a multivitamin would be protective in a well-nourished population (Bayesian probability) stating: "The plausibility of a protective effect is reduced by the absence of a clear path through which 30 different vitamins and minerals would cause a decline in the risk of multiple cancers and, especially, by the negative pattern of prior results." In addition the investigators observed no difference in effect whether the study participants were or were not adherent to the multivitamin intervention, which diminishes the dose–response relationship.[2]

The editorial was critical of the statistical multiplicity (multiple comparisons): the complete planned analysis of the primary and secondary end points in the PHS II study would entail 28 tests of association; each of which has "some possibility of yielding a statistically significant result by chance alone, even when there is no true treatment effect. [...] when this finding is considered in the context of the number of already completed and planned analyses of the same study, the strength of the inference is weaker, because the likelihood of a randomly occurring finding [...] is much greater." They concluded that any of the conventional P value corrections for multiple comparisons would eliminate the apparent "statistical significance" of the results.[2]

From the same double-blind study, they found that taking a daily multivitamin did not have any effect in reducing heart attacks and other major cardiovascular events, MI, stroke, and CVD mortality.[6]

## Contains

Incomplete list of the nutritional facts for each type of Centrum brand vitamin:

### Centrum Mens

Centrum Mens - Supplement Facts[7] Serving Size = 1 Tablet Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%)

|
|
|
|

Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene)
Vitamin C | 90,000 | 90 | 0.09 | 100
Vitamin D3 | 25 | 0.025 | 0.000025 | 125
Vitamin E | 20,300 | 20.3 | 0.0203 | 135
Vitamin K | 60 | 0.060 | 0.000006 | 50
Thiamin | 1,200 | 1.2 | 0.0012 | 100
Riboflavin | 1,300 | 1.3 | 0.0013 | 100
Niacin | 16,000 | 16 | 0.016 | 100
Vitamin B6 | 2,000 | 2 | 0.002 | 118
Folate | 333 | 0.333 | 0.000333 | 83
Vitamin B12 | 6 | 0.006 | 0.00006 | 250
Biotin | 40 | 0.04 | 0.0004 | 133
Pantothenic Acid | 15,000 | 15 | 0.015 | 300
Calcium | 210,000 | 210 | 0.21 | 16
Iron | 8,000 | 8 | 0.008 | 44
Phosphorus | 20,000 | 20 | 0.02 | 2
Iodine | 150 | 0.15 | 0.00015 | 100
Magnesium | 100,000 | 100 | 0.1 | 24
Zinc | 11,000 | 11 | 0.01 | 100
Selenium | 100 | 0.1 | 0.0001 | 182
Copper | 900 | 0.9 | 0.0009 | 100
Manganese | 2,300 | 2.3 | 0.0023 | 100
Chromium | 35 | 0.035 | 0.000035 | 100
Molybdenum | 50 | 0.05 | 0.00005 | 111
Chloride | 7,2000 | 72 | 0.072 | 3
Potassium | 8,000 | 80 | 0.08 | 2
Lycopene | 600 | 0.6 | 0.0006 | NE

NE = Not Established

### Centrum Womens

Centrum Womens - Supplement Facts[8] Serving Size = 1 Tablet Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%)

|
|
|
|

Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene)
Vitamin C | 75,000 | 75 | 0.075 | 83
Vitamin D3 | 25 | 0.025 | 0.000025 | 125
Vitamin E | 15,800 | 15.8 | 0.0203 | 105
Vitamin K | 50 | 0.050 | 0.000005 | 42
Thiamin | 1,100 | 1.1 | 0.0011 | 92
Riboflavin | 1,100 | 1.1 | 0.0011 | 85
Niacin | 14,000 | 14 | 0.014 | 88
Vitamin B6 | 2,000 | 2 | 0.002 | 118
Folate | 667 | 0.667 | 0.000667 | 167
Vitamin B12 | 6 | 0.006 | 0.00006 | 250
Biotin | 40 | 0.04 | 0.0004 | 133
Pantothenic Acid | 15,000 | 15 | 0.015 | 300
Calcium | 200,000 | 200 | 0.20 | 15
Iron | 18,000 | 18 | 0.018 | 100
Phosphorus | 20,000 | 20 | 0.02 | 2
Iodine | 150 | 0.15 | 0.00015 | 100
Magnesium | 100,000 | 100 | 0.1 | 24
Zinc | 8,000 | 8 | 0.08 | 24
Selenium | 18 | 0.018 | 0.0000018 | 33
Copper | 00 | 0.5 | 0.0005 | 56
Manganese | 1,800 | 1.8 | 0.0018 | 78
Chromium | 32 | 0.032 | 0.000032 | 91
Molybdenum | 50 | 0.05 | 0.00005 | 111
Chloride | 7,2000 | 72 | 0.072 | 3
Potassium | 8,000 | 80 | 0.08 | 2

### Centrum Adults

Centrum Adults - Supplement Facts[9] Serving Size = 1 Tablet Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%)

|
|
|
|

Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene)
Vitamin C | 60,000 | 60 | 0.06 | 67
Vitamin D3 | 25 | 0.025 | 0.000025 | 125
Vitamin E | 13,500 | 13.5 | 0.0135 | 90
Vitamin K | 25 | 0.025 | 0.0000025 | 21
Thiamin | 1,500 | 1.5 | 0.0015 | 125
Riboflavin | 1,700 | 1.7 | 0.0017 | 100
Niacin | 20,000 | 20 | 0.020 | 125
Vitamin B6 | 2,000 | 2 | 0.002 | 118
Folate | 667 | 0.667 | 0.000667 | 167
Vitamin B12 | 6 | 0.006 | 0.00006 | 250
Biotin | 30 | 0.03 | 0.0003 | 100
Pantothenic Acid | 10,000 | 10 | 0.010 | 200
Calcium | 200,000 | 200 | 0.20 | 15
Iron | 18,000 | 18 | 0.0018 | 100
Phosphorus | 20,000 | 20 | 0.02 | 2
Iodine | 150 | 0.15 | 0.00015 | 100
Magnesium | 50,000 | 50 | 0.050 | 12
Zinc | 11,000 | 11 | 0.01 | 100
Selenium | 55 | 0.055 | 0.000055 | 100
Copper | 500 | 0.5 | 0.0005 | 56
Manganese | 2,300 | 2.3 | 0.0023 | 100
Chromium | 35 | 0.035 | 0.000035 | 100
Molybdenum | 45 | 0.045 | 0.000045 | 100
Chloride | 7,2000 | 72 | 0.072 | 3
Potassium | 8,000 | 80 | 0.08 | 2

## References

1. ↑ "Wyeth sued by teachers group over Centrum ads". National Post: p. 2. 2003-09-18.
2. ↑ 2.0 2.1 2.2 Bach, Peter B.; Lewis, Roger J. (14 November 2012). "Multiplicities in the Assessment of Multiple Vitamins Is It Too Soon to Tell Men That Vitamins Prevent Cancer?". The Journal of the American Medical Association 308 (18): 1916–1917. doi:10.1001/jama.2012.53273. PMID 23150011.
3. ↑ Gaziano, J. Michael; Sesso, Howard D.; Christen, William G.; Bubes, Vadim; Smith, Joanne P.; MacFadyen, Jean; Schvartz, Miriam; Manson, JoAnn E. et al. (October 17, 2012). "Multivitamins in the Prevention of Cancer in Men - The Physicians' Health Study II Randomized Controlled Trial". JAMA 308 (18): 1871–80. doi:10.1001/jama.2012.14641. PMID 23162860.
4. ↑ Rabin, Roni Caryn (October 17, 2012). "Daily Multivitamin May Reduce Cancer Risk, Clinical Trial Finds". The New York Times. https://www.nytimes.com/2012/10/18/health/daily-multivitamin-may-reduce-cancer-risk-clinical-trial-finds.html. Retrieved October 17, 2012.
5. ↑ Winslow, Ron (18 October 2012). "Multivitamin Cuts Cancer Risk, Large Study Finds". The Wall Street Journal. https://www.wsj.com/articles/SB10000872396390444868204578062463819724232. Retrieved 13 December 2012.
6. ↑ Sesso, Howard D.; Christen, William G.; Bubes, Vadim; Smith, Joanne P.; MacFadyen, Jean; Schvartz, Miriam; Manson, JoAnn E.; Glynn, Robert J. et al. (November 7, 2012). "Multivitamins in the Prevention of Cardiovascular Disease in Men - The Physicians' Health Study II Randomized Controlled Trial". JAMA 308 (17): 1751–60. doi:10.1001/jama.2012.14805. PMID 23117775.
7. ↑ https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000770-web-ready-centrum-men-tablets-(version-2).pdf [bare URL PDF]
8. ↑ https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000773-web-ready-centrum-women-(version-2).pdf [bare URL PDF]
9. ↑ https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000767-web-ready-centrum-adults-(version-2).pdf [bare URL PDF]

## External links

* Official website
* Official UK website

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