Chitosan diacetate

Chitosan diacetate (CDA) is a chemical derivative of chitosan that can be synthesized by reaction with iodoacetic acid,. This polymer can be crosslinked with zinc chloride (ZnCl2), aluminum chloride (AlCl3), or calcium chloride (CaCl2), and the resulting matrices can be loaded with any drug. This crosslinking of chitosan diacetate matrices can modulate the drug release properties.[1][2]

## References

1. ↑ AlKhatib, Hatim S.; Aiedeh, Khaled M.; Bustanji, Yasser; Hamed, Saja; Mohammad, M.K.; AlKhalidi, Bashar; Najjar, Samer (November 2008). "Modulation of buspirone HCl release from hypromellose matrices using chitosan succinate: Implications for pH-independent release". European Journal of Pharmaceutics and Biopharmaceutics 70 (3): 804–812. doi:10.1016/j.ejpb.2008.06.017.
2. ↑ Aiedeh, Khaled M.; Taha, Mutasem O.; Al-Hiari, Yusuf; Bustanji, Yasser; AlKhatib, Hatim S. (January 2007). "Effect of Ionic Crosslinking on the Drug Release Properties ofChitosan Diacetate Matrices". Journal of Pharmaceutical Sciences 96 (1): 38–43. doi:10.1002/jps.20764.

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