Co-danthrusate

Short description: Pharmaceutical combination

Co-danthrusateCombination of

Dantron| stimulant laxative
Docusate| laxative
Identifiers
CAS Number|

* 117-10-2 Y

ChemSpider|

* none

UNII|

* Z4XE6IBF3V

Co-danthrusate is a combination of dantron and docusate. Dantron is a mild peristaltic stimulant which acts on the lower bowel to encourage normal bowel movement without causing irritation. It belongs to the group of medicines under the term stimulant laxative.[1] It stimulates the nerves in the stomach wall which causes the stomach muscles to contract. This medicine is used for analgesic-induced constipation. It takes six to twelve hours to work.[2] This can cause discoloration of urine and bowel and liver tumors.[3]

Co-danthramer is dantron plus poloxamer. It is (in the U.K.) only to be prescribed to terminally ill patients because of its carcinogenicity in rats. It is often prescribed to people taking long term opioid, because it relaxes the effect of opioid induced constipation. It will not alleviate the symptoms of opioid induced delayed gastric emptying and abdominal cramps.[4]

## See also

* Laxative
* Opioid

## References

1. ↑ "Constipation in Adults information. Causes and Treatment". http://patient.info/doctor/constipation-in-adults-pro.
2. ↑ "Co-danthrusate". 20 August 2007. http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100000561.html.
3. ↑ "co-danthrusate suspension". https://www.medthority.com/drugs/a-alimentary-tract-and-metabolism/a06/a06a/a06ab/a06ab53/co-danthrusate-suspension/.
4. ↑ "Constipation in people prescribed opioids". BMJ Clinical Evidence 2010. April 2010. PMID 21718572.

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