DCPG

Short description: Chemical

DCPG

Identifiers

IUPAC name

* 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid

CAS Number|

* 201730-11-2 Y

PubChem CID|

* 16062593

IUPHAR/BPS|

* 1407

ChemSpider|

* 17222214 N

UNII|

* W3Y53JA9W3

Chemical and physical data
Formula| C10H9NO6
Molar mass| 239.183 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* O=C(O)[C@@H](N)c1cc(c(C(=O)O)cc1)C(=O)O

InChI

* InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1 N

* Key:IJVMOGKBEVRBPP-ZETCQYMHSA-N N

NY (what is this?) (verify)

DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant effects in animal studies,[1][2] and has also been investigated as a possible treatment for hyperalgesia.[3]

## References

1. ↑ "Glutamate metabotropic receptors as targets for drug therapy in epilepsy". European Journal of Pharmacology 476 (1–2): 3–16. August 2003. doi:10.1016/s0014-2999(03)02149-6. PMID 12969743.
2. ↑ "Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid". Neuropharmacology 54 (4): 665–75. March 2008. doi:10.1016/j.neuropharm.2007.11.015. PMID 18191956.
3. ↑ "Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice". Neuropharmacology 52 (2): 253–62. February 2007. doi:10.1016/j.neuropharm.2006.04.006. PMID 17113112.

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*[CID]: Compound ID