DEA list of chemicals

Short description: none

The United States Drug Enforcement Administration (DEA) maintains lists regarding the classification of illicit drugs (see DEA Schedules). It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act[1] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.

Although the list is controlled by the Attorney General, the list is considered a DEA list because the DEA publishes and enforces the list.

Suppliers of these products are subject to regulation and control measures:[2]

Regulation  | List I  | List II  | Tableting and Encapsulating Machines  | Special Surveillance List

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Know your customer | X  | X  | X  | X
Annual manufacturing, inventory, and use reports for bulk manufacturers  | X  | X  | X  |
15 day advanced DEA notice required for imports, exports, and transshipments  | X  | X  |  |
15 day advanced DEA notice required for international transactions  | X  | X  |  |
Keep transaction records for at least two years  | X  | X  |  |
Maintain effective security controls  | X  | X  |  |
Required reporting for unusual sales and losses or sales to DEA-identified companies  | X  | X  |  |
Registration required for manufacturing, distribution, import, or export  | X  |  |  |
Reports of mail-order sales to non-regulated entities  | X  |  |  |

## Contents

* 1 List I chemicals
* 2 List II chemicals
* 3 Special Surveillance List
* 3.1 Chemicals
* 3.2 Equipment
* 4 See also
* 5 References
* 6 External links

## List I chemicals

These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances:[3]

Chemical  | Illicit drug

|

Alpha-phenylacetoacetonitrile and its salts, optical isomers, and salts of optical isomers (APAAN)  | phenylacetone, methamphetamine, amphetamine
Anthranilic acid, its esters, and its salts  | methaqualone and analogues
Benzyl cyanide | phenylacetic acid, phenylacetone, amphetamine
Ephedrine, its salts, optical isomers, and salts of optical isomers  | methamphetamine
Ergonovine and its salts  | lysergic acid diethylamide
Ergotamine and its salts  | lysergic acid diethylamide
N-Acetylanthranilic acid, its esters, and its salts  | methaqualone
Norpseudoephedrine, its salts, optical isomers, and salts of optical isomers  | amphetamine
Phenylacetic acid, its esters, and its salts  | phenylacetone, amphetamine, methamphetamine
Phenylpropanolamine, its salts, optical isomers, and salts of optical isomers  | amphetamine, methamphetamine
Piperidine and its salts  | phencyclidine and analogues
Pseudoephedrine, its salts, optical isomers, and salts of optical isomers  | methamphetamine
3,4-Methylenedioxyphenyl-2-propanone  | MDMA, MDA, MDEA, MDOH
Methylamine and its salts  | methamphetamine
Ethylamine and its salts  | etilamfetamine
Propionic anhydride | fentanyl
Isosafrole | MDMA, MDA
Safrole | MDMA, MDA
Piperonal | MDMA, MDA
N-Methylephedrine, its salts, optical isomers, and salts of optical isomers  | methamphetamine
N-Methylpseudoephedrine, its salts, optical isomers, and salts of optical isomers  | methamphetamine
Hydroiodic acid | methamphetamine, amphetamine
Benzaldehyde | methamphetamine, amphetamine
Nitroethane | methamphetamine, amphetamine
Gamma butyrolactone (other names include: GBL; dihydro-2(3H)-furanone; 1,2-butanolide; 1,4-butanolide; 4-hydroxybutanoic acid lactone; gamma-hydroxybutyric acid lactone)  | Gamma-Hydroxybutyric acid (GHB)
Red phosphorus | methamphetamine, amphetamine
White phosphorus (other names: yellow phosphorus)  | methamphetamine, amphetamine
Hypophosphorous acid and its salts (including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite and sodium hypophosphite)  | methamphetamine, amphetamine
N-Phenethyl-4-piperidone (NPP)  | fentanyl
Iodine | methamphetamine, amphetamine
Ergocristine and its salts  | lysergic acid diethylamide
N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide (benzylfentanyl) and its salts  | fentanyl
N-phenylpiperidin-4-amine(4-anilinopiperidine; N-phenyl-4-piperidinamine; 4-AP), its amides, its carbamates, and its salts  | fentanyl
3,4-MDP-2-P methyl glycidate (PMK glycidate) and its optical and geometric isomers  | MDMA and other "ecstasy"-type substances
3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) and its salts, optical and geometric isomers, and salts of isomers  | MDMA and other "ecstasy"-type substances
Alpha-phenylacetoacetamide (APAA) and its optical isomers  | amphetamine, methamphetamine
Methyl alpha-phenylacetoacetate (MAPA; methyl 3-oxo-2-phenylbutanoate) and its optical isomers  | phenylacetone, methamphetamine, amphetamine
4-Piperidone  | fentanyl
1-boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) and its salts  | fentanyl

## List II chemicals

These chemicals are designated as those that are used in the manufacture of controlled substances:[4]

1. Acetic anhydride
2. Acetone
3. Benzyl chloride
4. Diethyl ether
5. Potassium permanganate
6. 2-Butanone (or methyl ethyl ketone or MEK)
7. Toluene
8. Hydrochloric acid (including anhydrous hydrogen chloride)
9. Sulfuric acid
10. Methyl isobutyl ketone (MIBK)
11. Sodium permanganate

## Special Surveillance List

### Chemicals

All listed chemicals[5] as specified in 21 CFR 1310.02 (a) or (b). This includes supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls. For each chemical, its illicit manufacturing use is given in parentheses. Some Special Surveillance List chemicals do not have an exclusive manufacturing use for a specific illicit drug but rather have a broad range of uses in both legitimate and illicit manufacturing operations.

Chemical  | Illicit drug

|

Phenyl-2-nitropropene | substituted amphetamines
1-(4-bromophenyl)propan-1-one  | substituted cathinones and substituted amphetamines
1-(4-chlorophenyl)propan-1-one  | substituted cathinones and substituted amphetamines
1-(4-methylphenyl)propan-1-one  | substituted cathinones and substituted amphetamines
Carbonyldiimidazole | LSD
1,1-Dichloro-1-fluoroethane | solvent
N-benzyl-4-piperidone  | fentanyl
chloroephedrine  | methamphetamine
Butyrophenone | substituted cathinones
Valerophenone | substituted cathinones
Propiophenone | substituted cathinones
2C-H | 2C-x and DOx
2-bromo-1-(4-chlorophenyl)propan-1-one  | substituted cathinones and substituted amphetamines
2-bromo-1-(4-methoxyphenyl)propan-1-one  | substituted cathinones and substituted amphetamines
2-bromo-1-(4-methylphenyl)propan-1-one  | substituted cathinones and substituted amphetamines
2-bromo-1-phenylpentan-1-one  | substituted cathinones and substituted amphetamines
2-bromo-1-phenylpropan-1-one  | substituted cathinones and substituted amphetamines
BMK glycidic acid and esters  | methamphetamine
3-oxo-2-phenylbutanoic acid and its esters  | methamphetamine
3,4-methylenedioxyphenyl-2-nitropropene (MDP2NP)  | MDMA
Ammonia gas  | amphetamine, methamphetamine
Ammonium formate | amphetamine, methamphetamine
Azobisisobutyronitrile | radical initiator
Bromobenzene | phencyclidine
1,4-Butanediol | GHB and Gamma-Butyrolactone
Cyclohexanone | phencyclidine
Diethylamine and its salts  | lysergic acid diethylamide
ethyl 3-oxo-4-phenylbutanoate  | phenylacetone
ethyl-3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate (MDP2P ethyl glycidate)  | MDMA
Formamide | amphetamine, methamphetamine
Formic acid | amphetamine, methamphetamine
Lithium aluminum hydride  | amphetamine, methamphetamine
Lithium metal  | amphetamine, methamphetamine
Magnesium metal (turnings)  | phencyclidine
Mercuric chloride  | amphetamine, methamphetamine
methyl 2-(1,3-benzodioxol-5-yl)-3-oxobutanoate  | MDMA
N-Methylformamide | amphetamine, methamphetamine
Organomagnesium halides (Grignard reagents) (e.g. ethylmagnesium bromide and phenylmagnesium bromide)  | phencyclidine
ortho-Toluidine  | methaqualone
2-Phenylethyl bromide | fentanyl
Phenylethanolamine and its salts
Phosphorus pentachloride | lysergic acid diethylamide
Potassium dichromate | general-purpose oxidizing agent
Pyridine and its salts  | general-purpose solvent
Sodium borohydride | reducing agent
Sodium dichromate | general-purpose oxidizing agent
Sodium metal  | phenylacetone
Sodium triacetoxyborohydride | reducing agent
para-fluoro-1-boc-4-anilopiperidine  | parafluorofentanyl
Thioglycolic acid | modafinil
Thionyl chloride | lysergic acid diethylamide
Trichloromonofluoromethane (aka freon-11, carrene-2)
1,1,2-Trichloro-1,2,2-trifluoroethane (aka freon 113)

### Equipment

The equipment list:[5]

* 22-liter heating mantles
* Encapsulating machines
* Hydrogenators
* Tableting machines, including punches and dies

## See also

* Chemical Diversion and Trafficking Act
* Combat Methamphetamine Epidemic Act of 2005
* Drug precursors
* European law on drug precursors

## References

1. ↑ 21 U.S.C. § 802, paragraphs 34 (list I) and 35 (list II)
2. ↑ DEA (2013). "Chemical Handler's Manual". https://www.deadiversion.usdoj.gov/pubs/manuals/chem/chem_manual.pdf.
3. ↑ "eCFR :: 21 CFR 1310.02 -- Substances covered.". 2022-05-11. https://www.ecfr.gov/current/title-21/chapter-II/part-1310/section-1310.02.
4. ↑ "Title 21 CFR - PART 1310 - Section 1310.02 Substances covered". http://www.deadiversion.usdoj.gov/21cfr/cfr/1310/1310_02.htm. Retrieved August 28, 2014.
5. ↑ 5.0 5.1 "Special Surveillance List of Chemicals, Products, Materials and Equipment Used in the Clandestine Production of Controlled Substances or Listed Chemicals". Archived from the original on April 20, 2011. https://web.archive.org/web/20110420054619/http://www.deadiversion.usdoj.gov/chem_prog/advisories/surveillance.htm. Retrieved May 20, 2011.

## External links

* DEA Controlled Substance Schedules ()

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