Ethyl biscoumacetate

Short description: Pharmaceutical drug

Ethyl biscoumacetate

Clinical data
Trade names| Tromexan
ATC code|

* B01AA08 (WHO)

Identifiers

IUPAC name

* 3,3-(ethyl acetate-methylene)-bis(4-hydroxycoumarin)

CAS Number|

* 548-00-5 N

PubChem CID|

* 11047

DrugBank|

* DB08794 Y

ChemSpider|

* 10444159 Y

UNII|

* 08KL644731

KEGG|

* D07131 Y

ChEMBL|

* ChEMBL2106261 N

Chemical and physical data
Formula| C22H16O8
Molar mass| 408.362 g·mol−1

InChI

* InChI=1S/C22H16O8/c1-2-28-20(25)15(16-18(23)11-7-3-5-9-13(11)29-21(16)26)17-19(24)12-8-4-6-10-14(12)30-22(17)27/h3-10,15,23-24H,2H2,1H3 Y

* Key:JCLHQFUTFHUXNN-UHFFFAOYSA-N Y

NY (what is this?) (verify)

Ethyl biscoumacetate is a vitamin K antagonist.

## References

* The Merck Index, 12th Edition. 3818

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Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs|

| Glycoprotein IIb/IIIa inhibitors|

* Abciximab
* Eptifibatide
* Orbofiban
* Roxifiban
* Sibrafiban§
* Tirofiban

|

ADP receptor/P2Y12 inhibitors|

* Thienopyridines
* Clopidogrel
* Prasugrel
* Ticlopidine
* Nucleotide/nucleoside analogs
* Cangrelor
* Elinogrel
* Ticagrelor

Prostaglandin analogue (PGI2)|

* Beraprost
* Iloprost
* Prostacyclin
* Treprostinil

COX inhibitors|

* Acetylsalicylic acid/Aspirin#
* Aloxiprin
* Carbasalate calcium
* Indobufen
* Triflusal

Thromboxane inhibitors|

* Thromboxane synthase inhibitors
* Dipyridamole (\+ aspirin)
* Picotamide
* Terbogrel
* Receptor antagonists
* Terbogrel
* Terutroban§

Phosphodiesterase inhibitors|

* Cilostazol
* Dipyridamole
* Triflusal

Other|

* Cloricromen
* Ditazole
* Vorapaxar

Anticoagulants|

| Vitamin K antagonists
(inhibit II, VII, IX, X)|

* Coumarins: Acenocoumarol
* Coumatetralyl
* Dicoumarol
* Ethyl biscoumacetate
* Phenprocoumon
* Warfarin#
* 1,3-Indandiones: Clorindione
* Diphenadione
* Phenindione
* Other: Tioclomarol

|

Factor Xa inhibitors
(with some II inhibition)|

| Heparin group/
glycosaminoglycans/
(bind antithrombin)|

* Low molecular weight heparin
* Bemiparin
* Certoparin
* Dalteparin
* Enoxaparin
* Nadroparin
* Parnaparin
* Reviparin
* Tinzaparin
* Oligosaccharides
* Fondaparinux
* Idraparinux§
* Heparinoids
* Danaparoid
* Dermatan sulfate
* Sulodexide

|

Direct Xa inhibitors ("xabans")|

* Apixaban
* Betrixaban
* Darexaban§
* Edoxaban
* Otamixaban§
* Rivaroxaban

Direct thrombin (IIa) inhibitors|

* Bivalent: Hirudin
* Bivalirudin
* Desirudin
* Lepirudin
* Univalent: Argatroban
* Dabigatran
* Efegatran
* Inogatran§
* Melagatran‡
* Ximelagatran‡

Other|

* Antithrombin III
* Defibrotide
* Protein C
* Drotrecogin alfa‡
* Ramatroban
* REG1

Thrombolytic drugs/
fibrinolytics|

* Plasminogen activators: r-tPA
* Alteplase
* Reteplase
* Tenecteplase
* Desmoteplase†
* UPA
* Saruplase
* Urokinase
* Anistreplase
* Monteplase
* Streptokinase#
* Other serine endopeptidases: Ancrod
* Brinase
* Fibrinolysin

Non-medicinal|

* Citrate
* EDTA
* Oxalate

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
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* e

Types of coumarins

Aglycones|

* Aesculetin
* Ferujol
* Umbelliferone

| O-Methylated|

* Fraxetin
* Herniarin
* Osthol
* Scopoletin

|

glycosides|

* Aesculin
* Fraxin
* Skimmin
* Scopolin
* Umbelliferone 7-apiosylglucoside

derivatives|

| Furanocoumarins|

| Aglycones|

* Angelicin
* Marmesin
* Psoralen
* Vaginol
* Xanthotoxol

| O-Methylated|

* Bergapten
* Isopimpinellin
* Methoxsalen
* Trioxsalen

|

Furanocoumarin glycosides|

* Apterin

Meroterpene furanocoumarin ether|

* Auraptene
* Bergamottin
* Imperatorin

Oligomers|

* Dicoumarol

Synthetic|

* Acenocoumarol
* Coumatetralyl
* Ensaculin
* Ethyl biscoumacetate
* 4-Hydroxycoumarins
* Hymecromone
* Phenprocoumon
* Warfarin

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