Galnon

Short description: Chemical compound

Galnon

Identifiers

IUPAC name

* 9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate

CAS Number|

* 475115-35-6 Y

PubChem CID|

* 5311268

IUPHAR/BPS|

* 6118

ChemSpider|

* 4470781 N

ChEMBL|

* ChEMBL592414 N

Chemical and physical data
Formula| C40H46N4O6
Molar mass| 678.815 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* Cc3cc(=O)oc6cc(ccc36)NC(=O)C(CCCCN)NC(=O)C(CC5CCCCC5)NC(=O)OCC1c2ccccc2-c4c1cccc4

InChI

* InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1 N

* Key:IKNOZZKXIDSTRN-PXLJZGITSA-N N

NY (what is this?) (verify)

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]

## References

1. ↑ "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. May 2002. doi:10.1073/pnas.102163499. PMID 12011470. Bibcode: 2002PNAS...99.7136S.
2. ↑ "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides 39 (3): 161–3. June 2005. doi:10.1016/j.npep.2004.12.019. PMID 15944006.
3. ↑ "Regulation of feeding by galnon". Neuropeptides 38 (1): 55–61. February 2004. doi:10.1016/j.npep.2004.01.001. PMID 15003717.
4. ↑ "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. June 2005. doi:10.1016/j.npep.2004.12.010. PMID 15944018.
5. ↑ "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides 41 (5): 307–20. October 2007. doi:10.1016/j.npep.2007.05.001. PMID 17637475.
6. ↑ "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry 65 (5): 383–91. March 2009. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221.
7. ↑ "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology 204 (1): 95–102. May 2009. doi:10.1007/s00213-008-1438-7. PMID 19099295.

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*[CID]: Compound ID