Gostatin

Names
IUPAC name

3-Amino-5-(carboxymethyl)-4-oxo-2,3-dihydro-1H-pyridine-6-carboxylic acid

Identifiers

CAS Number

* 78416-84-9 Y

3D model (JSmol)

* Interactive image

ChemSpider |

* 91339

PubChem CID

* 101100

UNII |

* GNH8A5TAQ0

InChI

* InChI=UXFJYSFCCBPXED-UHFFFAOYSA-N

Key: 1S/C8H10N2O5/c9-4-2-10-6(8(14)15)3(7(4)13)1-5(11)12/h4,10H,1-2,9H2,(H,11,12)(H,14,15)

SMILES

* C1C(C(=O)C(=C(N1)C(=O)O)CC(=O)O)N

Properties

Chemical formula

| C8H10N2O5
Molar mass | 214.177 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Gostatin is an irreversible inhibitor of the aspartate aminotransferase[1][2] produced by the bacterium Streptomyces sumanensis.[1][3] Its structure is a dihydro-4-pyridone analog of glutamic acid.

## References

1. ↑ 1.0 1.1 Lanthorn, T.H.; Fagg, G.E. (April 1989). "Gostatin blocks physiological actions and binding of acidic amino acids in rat brain". Neuropharmacology 28 (4): 429–432. doi:10.1016/0028-3908(89)90041-5. PMID 2546088.
2. ↑ Coombs, Graham H. (7 October 1991) (in en). Biochemical Protozoology As A Basis For Drug Design. CRC Press. p. 115. ISBN 978-0-7484-0001-0.
3. ↑ Meurant, Gerard (2 December 2012) (in en). Actinomycetes in Biotechnology. Elsevier. p. 304. ISBN 978-0-08-098433-9.

## Further reading

* Friedman, Mendel (9 March 2013) (in en). Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Springer Science & Business Media. p. 536. ISBN 978-1-4757-0022-0.

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*[CID]: Compound ID