Harmol

Harmol is a chemical compound classified as a β-carboline.[1][2][3] It is readily formed in vivo in humans by O-demethylation of harmine.[4] Its elimination half-life has been reported to be about 1.5 to 2.0 hours.[5][6]

## See also

* Substituted β-carboline
* Harmalol

## References

1. ↑ "Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin". Oncol Rep 29 (4): 1333–42. 2013. doi:10.3892/or.2013.2242. PMID 23338618.
2. ↑ "Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol". Toxicol Lett 208 (1): 51–61. 2012. doi:10.1016/j.toxlet.2011.09.030. PMID 22001777. Bibcode: 2012ToxL..208...51E.
3. ↑ "The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells.". Biol Pharm Bull 34 (8): 1264–72. 2011. doi:10.1248/bpb.34.1264. PMID 21804216.
4. ↑ "The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro". Sci. Rep. 7 (1). 2017. doi:10.1038/s41598-017-05407-9. PMID 28706205. Bibcode: 2017NatSR...7.5309M.
5. ↑ "Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact". Pharmaceuticals (Basel) 13 (11): 334. October 2020. doi:10.3390/ph13110334. PMID 33114119.
6. ↑ "Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial". Int J Neuropsychopharmacol 28 (1). December 2024. doi:10.1093/ijnp/pyaf001. PMID 39774840.

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