Hetrombopag

Hetrombopag (also known as rafutrombopag; trade name Hengqu) is a pharmaceutical drug for the treatment of thrombocytopenia and anemia.[1][2][3]

It is a non-peptide small‐molecule thrombopoietin receptor agonist.[4]

In China, it is approved for second-line treatment for primary immune thrombocytopenic purpura (ITP) and severe aplastic anemia (SAA) in adults.[4]

## References

1. ↑ "Safety and efficacy of hetrombopag in patients with chronic immune thrombocytopenia: a single-arm, open-label, multi-center phase 1 study". Annals of Translational Medicine 10 (2): 30. January 2022. doi:10.21037/atm-21-4361. PMID 35282136.
2. ↑ "A multicenter, randomized phase III trial of hetrombopag: a novel thrombopoietin receptor agonist for the treatment of immune thrombocytopenia". Journal of Hematology & Oncology 14 (1): 37. February 2021. doi:10.1186/s13045-021-01047-9. PMID 33632264.
3. ↑ "Effectiveness and Safety of Hetrombopag-Containing Therapy in Patients with Severe Aplastic Anemia: A Multicenter Real-World Study". Blood 142: 5631. 2023. doi:10.1182/blood-2023-185469.
4. ↑ 4.0 4.1 "Hetrombopag: First Approval". Drugs 81 (13): 1581–1585. September 2021. doi:10.1007/s40265-021-01575-1. PMID 34357499.

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Antihemorrhagics (B02)

Antihemorrhagic|

| Systemic|

| Vitamin K|

* Phytomenadione (K1)
* Menadione (K3)

|

Coagulation
factors|

* intrinsic: IX/Nonacog alfa
* VIII/Moroctocog alfa/Turoctocog alfa

* extrinsic: VII/Eptacog alfa

* common: X
* II/Thrombin
* I/Fibrinogen
* XIII/Catridecacog

* combinations: Prothrombin complex concentrate (II, VII, IX, X, protein C and S)

Other
systemic|

* Batroxobin
* Carbazochrome
* Etamsylate
* Fostamatinib
* thrombopoietin receptor agonist
* Romiplostim
* Avatrombopag
* Eltrombopag
* Lusutrombopag

Local|

* Absorbable gelatin sponge
* Oxidized cellulose
* Tetragalacturonic acid hydroxymethylester
* Thrombin
* Collagen
* Calcium alginate
* Epinephrine/Adrenalone

Antifibrinolytics|

* amino acids
* Aminocaproic acid
* Tranexamic acid
* Aminomethylbenzoic acid
* serpins
* Aprotinin
* Alfa1 antitrypsin
* C1-inhibitor
* Camostat
* unsorted
* Ulinastatin

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