LY2828360

LY2828360 is a drug which acts as a potent, selective and long acting agonist of the cannabinoid CB2 receptor. It was effective against neuropathic pain and allodynia in animal models, but was unsuccessful in human clinical trials against arthritis pain.[1][2][3][4]

## References

1. ↑ "Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence". Molecular Pharmacology 93 (2): 49–62. February 2018. doi:10.1124/mol.117.109355. PMID 29192123.
2. ↑ "The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence". European Journal of Pharmacology 886. November 2020. doi:10.1016/j.ejphar.2020.173544. PMID 32896549.
3. ↑ "Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression". Cannabis and Cannabinoid Research 6 (5): 389–400. October 2021. doi:10.1089/can.2020.0059. PMID 33998863.
4. ↑ "The cannabinoid CB2 agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats". Neuropharmacology 265. March 2025. doi:10.1016/j.neuropharm.2024.110257. PMID 39644993.

* v
* t
* e

Cannabinoids

Phytocannabinoids|

* Alkylamides
* Caryophyllene
* CBC
* CBCV
* CBD
* CBDV
* CBG
* CBGM
* CBGV
* CBL
* CBDL
* CBN
* CBV
* Epigallocatechin gallate
* Gallocatechol
* Perrottetinene
* Serinolamide A
* THC
* THC-C4
* THCA
* THCV
* Yangonin

* Active metabolites: 8,11-DiOH-THC
* 11-COOH-THC
* 11-OH-THC

Endocannabinoids|

* Arachidonoyl ethanolamide (AEA; anandamide)
* 2-Arachidonoylglycerol (2-AG)
* 2-Arachidonyl glyceryl ether (2-AGE; noladin ether)
* 2-Oleoylglycerol (2-OG)
* N-Arachidonoyl dopamine (NADA)
* N-Arachidonylglycine (NAGly)
* 2-Arachidonoyl lysophosphatidylinositol (2-ALPI)
* N-Arachidonoyl serotonin (AA-5-HT)
* Docosatetraenoylethanolamide (DEA)
* Lysophosphatidylinositol (LPI)
* Oleamide
* Oleoylethanolamide (OEA)
* Palmitoylethanolamide (PEA)
* RVD-Hpα
* Stearoylethanolamide (SEA)
* O-Arachidonoyl ethanolamine (O-AEA; virodhamine)

Synthetic
cannabinoids|

| Classical cannabinoids
(dibenzopyrans)|

* A-40174
* A-41988
* A-42574
* Ajulemic acid
* AM-087
* AM-411
* AM-855
* AM-905
* AM-906
* AM-919
* AM-926
* AM-938
* AM-2389
* AM-4030
* AMG-1
* AMG-3
* AMG-36
* AMG-41
* Dexanabinol (HU-211)
* DMHP
* Dronabinol
* HHC
* HU-210
* HU-243
* JWH-051
* JWH-133
* JWH-139
* JWH-161
* JWH-229
* JWH-359
* KM-233
* L-759,633
* L-759,656
* Levonantradol (CP 50,5561)
* Menabitan
* Nabazenil
* Nabidrox (Canbisol)
* Nabilone
* Nabitan
* Naboctate
* O-224
* O-581
* O-774
* O-806
* O-823
* O-1057
* O-1125
* O-1191
* O-1238
* O-2048
* O-2113
* O-2365
* O-2372
* O-2373
* O-2383
* O-2426
* O-2484
* O-2545
* O-2694
* O-2715
* O-2716
* O-3223
* O-3226
* Parahexyl
* Pirnabine
* THC-O-acetate
* THC-O-phosphate

|

Non-classical
cannabinoids|

* Cannabicyclohexanol
* CBD-DMH
* CP 47,497
* (C6)-CP 47,497
* (C9)-CP 47,497
* CP 55,244
* CP 55,940
* HU-308
* HU-320
* HU-331
* HU-336
* HU-345
* HU-446
* HU-465
* HU-910
* HUF-101
* Nonabine
* O-1376
* O-1422
* O-1601
* O-1656
* O-1657
* O-1660
* O-1663
* O-1871
* SPA-229
* Tinabinol

Benzoylindoles|

* 1-Butyl-3-(2-methoxybenzoyl)indole
* 1-Butyl-3-(4-methoxybenzoyl)indole
* 1-Pentyl-3-(2-methoxybenzoyl)indole
* AM-630
* AM-679
* AM-694
* AM-1241
* AM-2233
* GW-405,833 (L-768,242)
* Pravadoline
* RCS-4
* WIN 54,461

Naphthoylindoles|

* AM-1220
* AM-1221
* AM-1235
* AM-2201
* AM-2232
* CHM-081
* EAM-2201
* FUB-JWH-018
* JWH-007
* JWH-015
* JWH-018
* JWH-019
* JWH-073
* JWH-081
* JWH-098
* JWH-116
* JWH-122
* JWH-149
* JWH-164
* JWH-182
* JWH-193
* JWH-198
* JWH-200
* JWH-210
* JWH-398
* JWH-424
* MAM-1220
* MAM-2201
* NE-CHMIMO

Naphthoylindazoles|

* THJ-018
* THJ-2201

Pyrrolobenzoxazines|

* WIN 55,212-2

Naphthylmethylindoles|

* JWH-175
* JWH-176
* JWH-184
* JWH-185
* JWH-192
* JWH-194
* JWH-195
* JWH-196
* JWH-197
* JWH-199

Phenylacetylindoles|

* Cannabipiperidiethanone
* JWH-167
* JWH-203
* JWH-249
* JWH-250
* JWH-251
* JWH-302
* RCS-8

Indole-3-carboxamides|

* 5F-ADBICA
* 5F-MDMB-PICA
* 5F-NNE1
* 5F-PCN
* 5F-SDB-006
* AB-FUBICA
* AB-PICA
* ADBICA
* ADB-FUBICA
* APICA
* CUMYL-BICA
* CUMYL-PICA
* CUMYL-5F-PICA
* FDU-NNE1
* MDMB-CHMICA
* MMB-CHMICA
* MMB-2201
* MN-25 (UR-12)
* NNE1
* PX-1
* Org 28312
* Org 28611
* SDB-006
* STS-135

Indole-3-carboxylates|

* 5F-PB-22
* FDU-PB-22
* FUB-PB-22
* QUCHIC (BB-22)
* QUPIC (PB-22)
* NM-2201

Tetramethylcyclo-
propanoylindoles|

* 5Br-UR-144
* 5Cl-UR-144
* A-796,260
* A-834,735
* FUB-144
* UR-144
* XLR-11
* XLR-12

Indazole-3-
carboxamides|

* 4F-MDMB-BINACA
* 5Cl-APINACA
* 5F-ADB
* 5F-ADB-PINACA
* 5F-AMB
* 5F-APINACA
* 5F-CUMYL-PINACA
* 5F-EDMB-PINACA
* 5F-EMB-PINACA
* AB-CHMINACA
* AB-FUBINACA
* AB-FUBINACA 2-fluorobenzyl isomer
* AB-PINACA
* ADB-CHMINACA
* ADB-FUBINACA
* ADB-PINACA
* Adamantyl-THPINACA
* ADSB-FUB-187
* AMB-CHMINACA
* AMB-FUBINACA
* APINACA (AKB48)
* APP-FUBINACA
* CUMYL-4CN-BINACA
* CUMYL-PINACA
* CUMYL-THPINACA
* EMB-FUBINACA
* FUB-APINACA
* MDMB-4en-PINACA
* MDMB-FUBINACA
* MDMB-CHMINACA
* MN-18
* PX-2
* PX-3

Tetramethylcyclo-
propanoylindazoles|

* FAB-144

Naphthoylpyrroles|

* JWH-030
* JWH-147
* JWH-307
* JWH-369
* JWH-370

Eicosanoids|

* AM-883
* AM-1346
* ACEA
* ACPA
* Methanandamide (AM-356)
* O-585
* O-689
* O-1812
* O-1860
* O-1861

Pyrazolecarboxamides|

* 5F-AB-FUPPYCA
* AB-CHFUPYCA

Others|

* 2F-QMPSB
* 4-HTMPIPO
* 5F-PY-PICA
* 5F-PY-PINACA
* 5F-3-pyridinoylindole
* A-836,339
* A-955,840
* Abnormal cannabidiol
* AB-001
* BzODZ-EPyr
* AM-1248
* AM-1714
* AZ-11713908
* AZD-1940
* BAY 38-7271
* BAY 59-3074
* BIM-018
* CB-13
* CB-86
* CBS-0550
* CUMYL-4CN-B7AICA
* 5F-CUMYL-P7AICA
* CUMYL-PEGACLONE
* FUBIMINA
* GSK-554,418A
* GW-842,166X
* JTE 7-31
* LASSBio-881
* LBP-1
* Leelamine
* MDA-7
* MDA-19
* MEPIRAPIM
* NESS-040C5
* NMP-7
* O-889
* O-1269
* O-1270
* O-1399
* O-1602
* O-2220
* Olorinab
* PF-03550096
* PSB-SB-1202
* PTI-1
* PTI-2
* PTI-3
* QMPSB
* S-444,823
* SER-601
* Tedalinab
* URB-447
* VSN-16
* WIN 56,098

Allosteric CBR ligands|

* Org 27569
* Org 27759
* Org 29647
* RTI-371
* Pregnenolone

Endocannabinoid
enhancers
(inactivation inhibitors)|

* 4-Nonylphenylboronic acid
* AM-404
* Arachidonoyl serotonin
* Arvanil
* BIA 10-2474
* Biochanin A
* CAY-10401
* CAY-10429
* Genistein
* Guineesine
* IDFP
* JNJ 1661010
* JNJ-42165279
* JZL184
* JZL195
* Kaempferol
* LY-2183240
* MK-4409
* O-1624
* O-2093
* Oleoylethanolamide (OEA)
* Olvanil
* Palmitoylethanolamide (PEA)
* PF-04457845
* PF-622
* PF-750
* PF-3845
* PHOP
* URB-447
* URB-597
* URB-602
* URB-754
* VDM-11

Anticannabinoids
(antagonists/inverse
agonists/antibodies)|

* AM-251
* AM-281
* AM-630
* AM-1387
* AM-4113
* AM-6527
* AM-6545
* BML-190
* Brizantin (Бризантин)
* CAY-10508
* CB-25
* CB-52
* CB-86
* Dietressa (Диетресса)
* Drinabant (AVE1625)
* Hemopressin
* Ibipinabant (SLV319)
* JTE-907
* LH-21
* LY-320,135
* MDA-77
* MJ-15
* MK-9470
* NESS-0327
* NIDA-41020
* O-606
* O-1184
* O-1248
* O-1918
* O-2050
* O-2654
* Otenabant (CP-945,598)
* PF-514273
* PipISB
* PSB-SB-487
* Rimonabant (SR141716)
* Rosonabant (E-6776)
* SR-144,528
* Surinabant (SR147778)
* Taranabant (MK-0364)
* TM-38837
* VCHSR

* See also: Cannabinoid receptor modulators (cannabinoids by pharmacology)
* List of: AM cannabinoids
* JWH cannabinoids
* Designer drugs § Synthetic cannabimimetics

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*[CBR]: Cannabinoid receptor