Lindgren oxidation

Short description: Method for oxidizing aldehydes to carboxylic acids

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Lindgren oxidation

Named after  | Bengt O. Lindgren
Reaction type  | Organic redox reaction
Identifiers
RSC ontology ID  | RXNO:0000287

Lindgren oxidation is a selective method for oxidizing aldehydes to carboxylic acids.[1] The reaction is named after Bengt O. Lindgren.

The oxidation takes place in water containing solvent mixtures under slightly acidic conditions (pH 3-5) with sodium chlorite as oxidizer. To avoid complicated oxidation reactions the hypochlorite, which is formed in the reaction, has to be removed from the reaction mixture by scavengers. In the original publication, sulfamic acid and resorcinol were used.[1] George A. Kraus and co-workers were the first to use 2-methyl-2-butene as scavenger under buffered conditions for the oxidation of an aliphatic and an α,β-unsaturated aldehyde.[2][3] Later hydrogen peroxide also proved to work to remove the hypochlorite.[4]

## See also

* Pinnick oxidation

## References

1. ↑ 1.0 1.1 Lindgren, Bengt O.; Nilsson, Torsten (1973). "Preparation of Carboxylic Acids from Aldehydes (Including Hydroxylated Benzaldehydes) by Oxidation with Chlorite". Acta Chemica Scandinavica 27: 888–890. doi:10.3891/acta.chem.scand.27-0888.
2. ↑ George A. Kraus; Bruce Roth (1980). "Synthetic studies toward verrucarol. 2. Synthesis of the AB ring system". The Journal of Organic Chemistry 45 (24): 4825–4830. doi:10.1021/jo01312a004. https://lib.dr.iastate.edu/chem_pubs/792.
3. ↑ George A. Kraus; Michael J. Taschner (1980). "Model studies for the synthesis of quassinoids. 1. Construction of the BCE ring system". The Journal of Organic Chemistry 45 (6): 1175–1176. doi:10.1021/jo01294a058. https://lib.dr.iastate.edu/chem_pubs/788.
4. ↑ Enrico Dalcanale; Fernando Montanari (1986). "Selective oxidation of aldehydes to carboxylic acids with sodium chlorite-hydrogen peroxide". The Journal of Organic Chemistry 51 (4): 567–569. doi:10.1021/jo00354a037.

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