MEAI

MEAI, also known as 5-methoxy-2-aminoindane (5-MeO-AI) and by its developmental code name CMND-100, is an entactogen-like psychoactive drug of the 2-aminoindane family.[1][2] It is a cyclized phenethylamine and is the 2-aminoindane analogue of 3-methoxyamphetamine.[3][2] The drug acts as a serotonin–norepinephrine releasing agent (SNRA) or as a modestly selective serotonin releasing agent (SSRA), with about 6-fold preference for induction of serotonin over norepinephrine release.[2] MEAI has been encountered as a novel designer recreational drug.[4][5] It is also under development for potential medical use in the treatment of alcoholism, cocaine use disorder, metabolic syndrome, and obesity.[6][7][8][9]

## Contents

* 1 Use and effects
* 2 Interactions
* 3 Pharmacology
* 3.1 Pharmacodynamics
* 4 Chemistry
* 5 History
* 5.1 Alcohol substitute
* 6 Research
* 7 See also
* 8 References
* 9 External links

## Use and effects

When used recreationally, MEAI is reported to produce mild to moderate psychoactive effects, including stimulation and euphoria.[2][5][4] Its dose is said to be 100 to 250 mg orally and 30 to 60 mg intranasally.[5] The drug is sometimes used as an alcohol substitute.[5]

## Interactions

## Pharmacology

### Pharmacodynamics

MEAI acts as a monoamine releasing agent (MRA).[2] It is a modestly selective serotonin releasing agent (SSRA), with 6-fold preference for induction of serotonin release over norepinephrine release and 20-fold preference for induction of serotonin release over dopamine release.[2] In addition to inducing monoamine neurotransmitter release, MEAI has moderate affinity for the α2-adrenergic receptor.[2] Based on these findings, MEAI might produce MDMA-like entactogenic and sympathomimetic effects but may be expected to have reduced misuse liability in comparison.[2]

Activities of 2-aminoindanes and amphetamine relatives Compound | Monoamine release (EC50, nM) | Ref

|
|

Serotonin | Norepinephrine | Dopamine
2-AI | >10,000 | 86 | 439 | [2]
MDAI | 114 | 117 | 1,334 | [2]
MMAI | 31 | 3,101 | >10,000 | [2]
MEAI | 134 | 861 | 2,646 | [2]
d-Amphetamine | 698–1,765 | 6.6–7.2 | 5.8–24.8 | [10][11][12][13][14]
MDA | 160–162 | 47–108 | 106–190 | [15][12][16]
MDMA | 50–85 | 54–110 | 51–278 | [10][17][18][15][16]
3-MA | ND | 58.0 | 103 | [12]
Notes: The smaller the value, the more strongly the compound produces the effect. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs: [2]

## Chemistry

MEAI, also known as 5-methoxy-2-aminoindane, is a substituted 2-aminoindane derivative.[3][2] It is a cyclized phenethylamine and is the 2-aminoindane analogue of the amphetamine 3-methoxyamphetamine.[3][2]

## History

MEAI appears to have been first synthesized in 1956.[2][5] The 2-aminoindane family of compounds was perhaps first chemically described in 1980.[19][20] MEAI's molecular structure was first mentioned implicitly in a markush structure schema appearing in a patent from 1998.[21] It was later described by David Nutt and colleagues as a potential preventative against binge drinking in the mid-2010s and thereafter.[4][22][23][24] The drug also emerged as a novel designer recreational drug by the mid-2010s.[4][23][5]

### Alcohol substitute

MEAI was an early candidate of alcohol replacement drugs that came to market during a late-2010s movement to replace alcohol with less-toxic alternatives advocated by British psychopharmacologist David Nutt and others.[25][26][27][28]

In an act of gonzo journalism, Michael Slezak writing for New Scientist, tried and reported on his experience with MEAI following an interview.[23] Ezekiel Golan is said to have developed MEAI and originally intended for it to be sold as a legal high, but changed his mind, indicating plans to work with Nutt and his company DrugScience. The goal was to develop MEAI further as a "binge behaviour regulator"[29] and "alcoholic beverage substitute".[30]

In 2018, a company called Diet Alcohol Corporation of the Americas (DACOA) began openly marketing an MEAI-based drink called "Pace" for sale in the United States and Canada. Pace was described as a 50 mL bottle containing 160 mg of MEAI in mineral water. Distribution halted after Health Canada released a warning indicating the substance was considered illegal to market for consumption in Canada due to structural similarity to amphetamine.[31][32] After this, Golan revealed himself to be the developer of Pace.[33] He claimed that the MEAI featured in Pace was "manufactured in India" and "bottled in Delaware".[33] Health Canada provided a statement to CBC News stating "Pace is an illegal and unauthorized product in Canada."[33]

## Research

MEAI, under the developmental code name CMND-100, is under development by Clearmind Medicine for the treatment of alcoholism, cocaine use disorder, metabolic syndrome, and obesity.[6][7][8][9] As of February 2026, it is in phase 1/2 clinical trials for treatment of alcoholism and is in the preclinical stage of development for all other indications.[6][7][8]

## See also

* Substituted 2-aminoindane
* Cyclized phenethylamine
* List of investigational hallucinogens and entactogens

## References

1. ↑ "The Potential Therapeutic Effects of MEAI in the Treatment of Alcohol Use Disorder". Current Addiction Reports 12 (1). 2 December 2025. doi:10.1007/s40429-025-00700-4. ISSN 2196-2952. https://link.springer.com/10.1007/s40429-025-00700-4. Retrieved 19 December 2025.
2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 "2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors". Psychopharmacology 236 (3): 989–999. March 2019. doi:10.1007/s00213-019-05207-1. PMID 30904940.
3. ↑ 3.0 3.1 3.2 "Novel serotonergic agents". Drug Design and Discovery 9 (3–4): 299–312. 1993. PMID 8400010.
4. ↑ 4.0 4.1 4.2 4.3 "Toxicological evaluation of 5-methoxy-2-aminoindane (MEAI): Binge mitigating agent in development". Toxicology and Applied Pharmacology 319: 59–68. March 2017. doi:10.1016/j.taap.2017.01.018. PMID 28167221. Bibcode: 2017ToxAP.319...59S. "5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action described by one patent as being possibly mediated by binding to the dopamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience (Nutt, 2013; Slezak, 2014). Typically recreational users ingest orally MEAI at doses of up to 1–2 mg/kg body weight in a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages.".
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "5-MeO-AI" (in ru). https://aipsin.com/newsubstance/472/.
6. ↑ 6.0 6.1 6.2 "Revolutionary Psychedelics for Treating Addiction & Mental Health". 16 December 2024. https://www.clearmindmedicine.com/news-release/clearmind-medicine-announces-irb-approval-for-fda-first-in-human-clinical-trial-of-cmnd-100-at-second-clinical-site.
7. ↑ 7.0 7.1 7.2 "Delving into the Latest Updates on CMND-100 with Synapse". 27 February 2026. https://synapse.patsnap.com/drug/9deb991430f947ca953ee34f8b3a60f2.
8. ↑ 8.0 8.1 8.2 "CMND-100 Drug Profile". 1 January 1900. https://pryzm.ozmosi.com/product/27783.
9. ↑ 9.0 9.1 וינרב ג (16 February 2022). "החברה שמנסה להפוך סם פסיכדלי למוצר נגד התמכרות" (in Hebrew). Globes. https://www.globes.co.il/news/article.aspx?did=1001402418.
10. ↑ 10.0 10.1 "Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin". Synapse 39 (1): 32–41. January 2001. doi:10.1002/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3. PMID 11071707.
11. ↑ "Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products". Neuropsychopharmacology 38 (4): 552–562. March 2013. doi:10.1038/npp.2012.204. PMID 23072836.
12. ↑ 12.0 12.1 12.2 "Dopamine-releasing agents". Dopamine Transporters: Chemistry, Biology and Pharmacology. Hoboken [NJ]: Wiley. July 2008. pp. 305–320. ISBN 978-0-470-11790-3. OCLC 181862653. https://bitnest.netfirms.com/external/Books/Dopamine-releasing-agents_c11.pdf.
13. ↑ "Structure-Activity Relationships of Synthetic Cathinones". Neuropharmacology of New Psychoactive Substances (NPS). Current Topics in Behavioral Neurosciences. 32. 2017. pp. 19–47. doi:10.1007/7854_2016_41. ISBN 978-3-319-52442-9.
14. ↑ "Profiling CNS Stimulants with a High-Throughput Assay for Biogenic Amine Transporter Substrates". Problems of Drug Dependence 1999: Proceedings of the 61st Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. NIDA Res Monogr. 180. 1999. pp. 1–476. https://archives.nida.nih.gov/sites/default/files/180.pdf#page=261. "RESULTS. Methamphetamine and amphetamine potently released NE (IC50s = 14.3 and 7.0 nM) and DA (IC50s = 40.4 nM and 24.8 nM), and were much less potent releasers of 5-HT (IC50s = 740 nM and 1765 nM). [...]"
15. ↑ 15.0 15.1 "3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro". Molecular Pharmacology 63 (6): 1223–1229. June 2003. doi:10.1124/mol.63.6.1223. PMID 12761331.
16. ↑ 16.0 16.1 "The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats". Psychopharmacology 237 (12): 3703–3714. December 2020. doi:10.1007/s00213-020-05648-z. PMID 32875347.
17. ↑ "The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue". Neuropsychopharmacology 37 (5): 1192–1203. April 2012. doi:10.1038/npp.2011.304. PMID 22169943.
18. ↑ "The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue". Neuropharmacology 101: 68–75. February 2016. doi:10.1016/j.neuropharm.2015.09.004. PMID 26362361.
19. ↑ "Aminoindanes--the next wave of 'legal highs'?". Drug Testing and Analysis 3 (7–8): 479–482. 2011. doi:10.1002/dta.318. PMID 21748859.
20. ↑ "Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene". Journal of Medicinal Chemistry 23 (7): 745–749. July 1980. doi:10.1021/jm00181a009. PMID 7190613.
21. ↑ Haadsma-Svensson SR, Andersson BR, Sonesson CA, Lin CH, Waters RN, Svensson KA, Carlsson PA, Hansson LO, Stjernlof NP, "2-aminoindans as selective dopamine D3 ligands", US patent 5708018, published 1998-01-13, assigned to Pharmacia & Upjohn Co.
22. ↑ "Pharmacokinetic and pharmacodynamic evaluation of 5-methoxy-2-aminoindane (MEAI): A new binge-mitigating agent". Toxicology and Applied Pharmacology 343: 29–39. March 2018. doi:10.1016/j.taap.2018.02.009. PMID 29458138. Bibcode: 2018ToxAP.343...29S.
23. ↑ 23.0 23.1 23.2 "High and dry? Party drug could target excess drinking" (in en-US). 30 December 2014. https://www.newscientist.com/article/mg22530022-900-high-and-dry-party-drug-could-target-excess-drinking/.
24. ↑ Nutt, David (11 November 2013). "Alcohol without the hangover? It's closer than you think". https://www.theguardian.com/commentisfree/2013/nov/11/alcohol-benefits-no-dangers-closer-think.
25. ↑ "Decision making about illegal drugs: time for science to take the lead" (in en). Nobel Forum, Karolinska Institutet. 23 October 2013. https://www.youtube.com/watch?v=mDo09IBVHZw.
26. ↑ "Drug harms in the UK: a multicriteria decision analysis". Lancet 376 (9752): 1558–1565. November 2010. doi:10.1016/S0140-6736(10)61462-6. PMID 21036393. Bibcode: 2010Lanc..376.1558N.
27. ↑ "Hangover free alcohol is finally here" (in en). The Independent. 24 September 2016. https://www.independent.co.uk/life-style/health-and-families/health-news/hangover-free-alcohol-david-nutt-alcosynth-nhs-postive-effects-benzodiazepine-guy-bentley-a7324076.html.
28. ↑ "Rauschmittel und gesellschaftliche Probleme" (in de-DE). 29 April 2019. https://benedictwermter.com/gesellschaftliche-probleme-und-rauschmittel-drug-related-societal-issues/.
29. ↑ Golan E, "Binge behavior regulators", US patent 10406123B2, issued 2019-09-10
30. ↑ Golan E, "Alcoholic beverage substitutes", US patent 20170360067, issued 2017-12-21
31. ↑ "Advisory - Health Canada warns consumers that Pace, promoted as an alcohol substitute, is unauthorized and may pose serious health risks". Health Canada. 21 December 2018. https://www.newswire.ca/news-releases/advisory
health-canada-warns-consumers-that-pace-promoted-as-an-alcohol-substitute--is-unauthorized-and-may-pose-serious-health-risks-703346102.html.
32. ↑ "FACT CHECK: Is Pace, an "Alcohol Alternative," Legal in Canada?". The Walrus. Toronto, Ontario. 24 April 2019. https://www.thewalrus-factchecking.com/post/fact-check-is-pace-an-alcohol-alternative-legal-in-canada.
33. ↑ 33.0 33.1 33.2 "Is this drink really a new 'alcohol alternative'?". Information Morning Saint John: pp. All. 8 December 2018. https://www.cbc.ca/news/canada/new-brunswick/pace-drink-alcohol-alternative-binge-drinking-canada-1.4933533.

## External links

* 5-MeO-AI (MEAI) - Isomer Design

* v
* t
* e

Empathogens/entactogens

Phenylalkyl-
amines
(other than
cathinones)|

* Unfused benzene ring: 3-CMA
* 4-CAB
* 4-FA
* 4-MA
* 4-MMA
* 4-FMA
* 4-MTA
* 4,4'-DMAR
* Ariadne
* Metaescaline
* MMA
* PMA
* PMEA
* PMMA
* mMMA
Benzodioxine: EDMA
Benzodioxoles: Phenethylamine: { Lophophine }
* Amphetamines: { 2-Methyl-MDA
* 2,3-MDA
* 3,4-MDA (tenamfetamine)
* 5-Methyl-MDA
* 6-Methyl-MDA
* DiFMDA
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* EIDA
* MDEA
* MDMA (midomafetamine)
* MDMOH
* MDOH
* MMDA
* MMDA-2
* MMDMA }
* 1-Phenylbutan-2-amines: { BDB
* EBDB
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* Phentermines: { MDMP
* MDPH }
Benzofurans and dihydrobenzofurans: 5-APB
* 5-APDB
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Indanes: 5-APDI
* 5-MAPDI
Indoles: 5-IT
* 6-API
Naphthalenes: Methamnetamine
* Naphthylaminopropane
Tetralin: 6-APT

Cyclized phenyl-
alkylamines|

* Aminoindanes: 5-IAI
* AMMI
* ETAI
* MDAI
* MDMAI
* MMAI
* MEAI
* NM-2-AI
* TAI
Aminotetralins: 6-CAT
* MDAT
* MDMAT

Cathinones|

* 3-MMC
* 4-EMC
* Brephedrone
* Butylone
* Ethylone
* Eutylone
* Flephedrone
* Mephedrone
* Methedrone
* Methylone
* TH-PVP

Tryptamines|

* 4-Methyl-αET
* αET
* αMT

Chemical classes|

* Substituted amphetamine
* Sub. benzofuran
* Sub. cathinone
* Sub. MDPEA
* Sub. PEA
* Sub. tryptamine

* v
* t
* e

Monoamine releasing agents

DRAs|

* Morpholines: Fenbutrazate
* Fenmetramide
* Morazone
* Morforex
* Phendimetrazine
* Phenmetrazine
* Pseudophenmetrazine

* Oxazolines: 4-MAR
* Aminorex
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* Cyclazodone
* Fenozolone
* Fluminorex
* Pemoline
* Thozalinone

* Phenethylamines: 2-OH-PEA
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* Dimethylamphetamine
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* Etilamfetamine
* Famprofazone
* Fenethylline
* Fenproporex
* Flephedrone
* Fludorex
* Furfenorex
* Hordenine
* 4-Hydroxyamphetamine
* Iofetamine (123I)
* Lophophine
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* Metamfepramone
* Methamphetamine
* Dextromethamphetamine
* Levomethamphetamine
* Methcathinone
* Methedrone
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* Ortetamine
* pBA
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* pIA
* Pholedrine
* Phenethylamine
* Pholedrine
* Phenpromethamine
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Tiflorex
* Tyramine
* Xylopropamine
* Zylofuramine

* Piperazines: 2C-B-BZP
* BZP
* MBZP
* MDBZP
* MeOPP
* oMPP

* Others: 2-ADN
* 2-AI
* 2-AT
* 4-BP
* 5-APDI
* 5-IAI
* Amineptine
* Clofenciclan
* Cyclopentamine
* Cypenamine
* Cyprodenate
* Feprosidnine
* Gilutensin
* Heptaminol
* Hexacyclonate
* Indanorex
* Isometheptene
* Methylhexanamine
* Naphthylaminopropane
* Octodrine
* Phthalimidopropiophenone
* Phenylbiguanide
* Propylhexedrine
* Levopropylhexedrine

NRAs|

* Morpholines: Fenbutrazate
* Fenmetramide
* Morazone
* Morforex
* Phendimetrazine
* Phenmetrazine
* Pseudophenmetrazine

* Oxazolines: 4-MAR
* Aminorex
* Clominorex
* Cyclazodone
* Fenozolone
* Fluminorex
* Pemoline
* Thozalinone

* Phenethylamines: 2-OH-PEA
* 4-CAB
* 4-FA
* 4-FMA
* 4-MA
* 4-MMA
* Alfetamine
* Amfecloral
* Amfepentorex
* Amfepramone
* Amphetamine
* Dextroamphetamine
* Levoamphetamine
* Amphetaminil
* β-Me-PEA
* BDB
* Benzphetamine
* BOH
* Buphedrone
* Butylone
* Cathine
* Cathinone
* Clobenzorex
* Clortermine
* Dimethylamphetamine
* DMA
* DMMA
* EBDB
* Ephedrine
* Ethcathinone
* Ethylone
* Etilamfetamine
* Famprofazone
* Fenethylline
* Fenproporex
* Flephedrone
* Fludorex
* Furfenorex
* Hordenine
* 4-Hydroxyamphetamine
* 5-APDI (IAP)
* Iofetamine (123I)
* Lisdexamfetamine
* Lophophine
* MBDB
* MDA (tenamfetamine)
* MDEA
* MDMA (midomafetamine)
* Metamfepramone
* MDMPEA
* MDOH
* MDPEA
* Mefenorex
* Mephedrone
* Mephentermine
* Methamphetamine
* Dextromethamphetamine
* Levomethamphetamine
* Methcathinone
* Methedrone
* Methylone
* Morforex
* Naphthylaminopropane
* Ortetamine
* pBA
* pCA
* Pentorex
* Phenethylamine
* Pholedrine
* Phenpromethamine
* Phentermine
* Phenylpropanolamine
* pIA
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Selegiline (also D-Deprenyl)
* Tiflorex
* Tyramine
* Xylopropamine
* Zylofuramine

* Piperazines: 2C-B-BZP
* BZP
* MBZP
* mCPP
* MDBZP
* MeOPP
* oMPP
* pFPP

* Others: 2-ADN
* 2-AI
* 2-AT
* 2-BP
* 4-BP
* 5-IAI
* Clofenciclan
* Cyclopentamine
* Cypenamine
* Cyprodenate
* Feprosidnine
* Gilutensin
* Heptaminol
* Hexacyclonate
* Indanorex
* Isometheptene
* Methylhexanamine
* Octodrine
* Phthalimidopropiophenone
* Propylhexedrine (Levopropylhexedrine)
* Tuaminoheptane

SRAs|

* Aminoindanes: 5-IAI
* AMMI
* ETAI
* MDAI
* MDMAI
* MMAI
* TAI

* Aminotetralins: 6-CAT
* 8-OH-DPAT
* MDAT
* MDMAT

* Oxazolines: 4-Methylaminorex
* Aminorex
* Clominorex
* Fluminorex

* Phenethylamines: 2-Methyl-MDA
* 4-CAB
* 4-FA
* 4-FMA
* 4-HA
* 4-MTA
* 5-APDB
* 5-Methyl-MDA
* 6-APDB
* 6-Methyl-MDA
* AEMMA
* Amiflamine
* BDB
* BOH
* Brephedrone
* Butylone
* Chlorphentermine
* Cloforex
* Amfepramone
* Metamfepramone
* DCA
* Dexfenfluramine
* DFMDA
* DMA
* DMMA
* EBDB
* EDMA
* Ethylone
* Etolorex
* Fenfluramine
* Flephedrone
* Flucetorex
* IAP
* Iofetamine
* Levofenfluramine
* Lophophine
* MBDB
* MDA (tenamfetamine)
* MDEA
* MDHMA
* MDMA (midomafetamine)
* MDMPEA
* MDOH
* MDPEA
* Mephedrone
* Methedrone
* Methylone
* MMA
* MMDA
* MMDMA
* MMMA
* NAP
* Norfenfluramine
* 4-TFMA
* pBA
* pCA
* pIA
* PMA
* PMEA
* PMMA
* TAP

* Piperazines: 2C-B-BZP
* 3-MeOPP
* BZP
* DCPP
* MBZP
* mCPP
* MDBZP
* MeOPP
* Mepiprazole
* oMPP
* pCPP
* pFPP
* pTFMPP
* TFMPP

* Tryptamines: 4-Methyl-αET
* 4-Methyl-αMT
* 5-CT
* 5-MeO-αET
* 5-MeO-αMT
* 5-MT
* αET
* αMT
* DMT
* Tryptamine

* Others: Indeloxazine
* Viqualine

Others|

* Monoamine activity enhancers: BPAP
* PPAP

* DAT modulators: Agonist-like: SoRI-9804
* SoRI-20040; Antagonist-like: SoRI-20041

* Adrenergic release blockers: Bethanidine
* Bretylium
* Guanadrel
* Guanazodine
* Guanethidine
* Guanoxan

See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins

* v
* t
* e

Phenethylamines

Phenethylamines|

* Psychedelics: 25B-NBOMe
* 25C-NBOMe
* 25D-NBOMe
* 25I-NBOMe
* 25N-NBOMe

* 2C-B
* 2C-B-AN
* 2C-Bn
* 2C-Bu
* 2C-C
* 2C-CN
* 2C-CP
* 2C-D
* 2C-E
* 2C-EF
* 2C-F
* 2C-G
* 2C-G-1
* 2C-G-2
* 2C-G-3
* 2C-G-4
* 2C-G-5
* 2C-G-6
* 2C-G-N
* 2C-H
* 2C-I
* 2C-iP
* 2C-N
* 2C-NH2
* 2C-O
* 2C-O-4
* 2C-P
* 2C-Ph
* 2C-SE
* 2C-T
* 2C-T-2
* 2C-T-3
* 2C-T-4
* 2C-T-5
* 2C-T-6
* 2C-T-7
* 2C-T-8
* 2C-T-9
* 2C-T-10
* 2C-T-11
* 2C-T-12
* 2C-T-13
* 2C-T-14
* 2C-T-15
* 2C-T-16
* 2C-T-17
* 2C-T-18
* 2C-T-19
* 2C-T-20
* 2C-T-21
* 2C-T-22
* 2C-T-22.5
* 2C-T-23
* 2C-T-24
* 2C-T-25
* 2C-T-27
* 2C-T-28
* 2C-T-30
* 2C-T-31
* 2C-T-32
* 2C-T-33
* 2C-TFE
* 2C-TFM
* 2C-YN
* 2C-V

* Allylescaline
* DESOXY
* Escaline
* Isoproscaline
* Jimscaline
* Macromerine
* MEPEA
* Mescaline
* Metaescaline
* Methallylescaline
* Proscaline
* Psi-2C-T-4
* TCB-2
Stimulants: Phenylethanolamine
* Hordenine
* Phenethylamine
* α-Methylphenethylamine (amphetamine)
* β-Methylphenethylamine
* m-Methylphenethylamine
* N-Methylphenethylamine
* o-Methylphenethylamine
* p-Methylphenethylamine
* Methylphenidate

* Entactogens: Lophophine
* MDPEA
* MDMPEA
Others: BOH
* DMPEA

Amphetamines|

* Psychedelics: 3C-BZ
* 3C-E
* 3C-P
* Aleph
* Beatrice
* Bromo-DragonFLY
* D-Deprenyl
* DMA
* DMCPA
* DMMDA
* DOB
* DOC
* DOEF
* DOET
* DOI
* DOM
* DON
* DOPR
* DOTFM
* Ganesha
* MMDA
* MMDA-2
* Psi-DOM
* TMA
* TeMA
Stimulants: 2-FA
* 2-FMA
* 3-FA
* 3-FMA
* Acridorex
* Alfetamine
* Amfecloral
* Amfepentorex
* Amphetamine (Dextroamphetamine, Levoamphetamine)
* Amphetaminil
* Benfluorex
* Benzphetamine
* Cathine
* Clobenzorex
* Dimethylamphetamine
* Ephedrine
* Etilamfetamine
* Fencamfamin
* Fencamine
* Fenethylline
* Fenfluramine (Dexfenfluramine, Levofenfluramine)
* Fenproporex
* Flucetorex
* Fludorex
* Formetorex
* Furfenorex
* Gepefrine
* 4-Hydroxyamphetamine
* Iofetamine
* Isopropylamphetamine
* Lefetamine
* Lisdexamfetamine
* Mefenorex
* Metaraminol
* Methamphetamine (Dextromethamphetamine, Levomethamphetamine)
* Methoxyphenamine
* MMA
* Morforex
* Norfenfluramine
* L -Norpseudoephedrine
* N,alpha-Diethylphenylethylamine
* Oxifentorex
* Oxilofrine
* Ortetamine
* PBA
* PCA
* Phenpromethamine
* PFA
* PFMA
* PIA
* PMA
* PMEA
* PMMA
* Phenylpropanolamine
* Pholedrine
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Sibutramine
* Tiflorex
* Tranylcypromine
* Xylopropamine
* Zylofuramine
Entactogens: 4-FA
* 4-FMA
* 4-MA
* 4-MMA
* 4-MTA
* 5-APB
* 5-APDB
* 5-EAPB
* 5-IT
* 5-MAPB
* 5-MAPDB
* 6-APB
* 6-APDB
* 6-Chloro-MDMA
* 6-EAPB
* 6-IT
* 6-MAPB
* 6-MAPDB
* EDA
* IAP
* 2,3-MDA
* 3,4-MDA (tenamfetamine)
* MDEA
* MDHMA
* MDMA (midomafetamine)
* MDOH
* Methamnetamine
* MMDMA
* Naphthylaminopropane
* TAP
Others: 3,4-DCA
* Amiflamine
* DiFMDA
* Selegiline (also D -Deprenyl)

Phentermines|

* Stimulants: Chlorphentermine
* Cloforex
* Clortermine
* Etolorex
* Mephentermine
* Pentorex
* Phentermine
Entactogens: MDPH
* MDMPH
Others: Cericlamine

Cathinones|

* Stimulants: 3-FMC
* 4-MC
* 4-BMC
* 4-CMC
* 4-EMC
* 4-FMC
* 4-MEC
* 4-MeMABP
* 4-MPD
* Amfepramone
* Benzedrone
* Brephedrone
* Buphedrone
* Bupropion
* Cathinone
* Dimethylcathinone
* Ethcathinone
* Eutylone
* Hydroxybupropion
* Methcathinone
* Methedrone
* NEB
* N-Ethylhexedrone
* N-Ethylpentedrone
* Pentedrone
* Pentylone
* Radafaxine
Entactogens: 3,4-DMMC
* 3-MMC
* Butylone
* Ethylone
* Methylone
* Methylenedioxycathinone
* Mephedrone

Phenylisobutylamines|

* Entactogens: 4-CAB
* 4-MAB
* Ariadne
* BDB
* Butylone
* EBDB
* Eutylone
* MBDB
Stimulants: Phenylisobutylamine

Phenylalkylpyrrolidines|

* Stimulants: α-PBP
* α-PHP
* α-PPP
* α-PVP
* MDPBP
* MDPPP
* MDPV
* 4-MePBP
* 4-MePHP
* 4-MePPP
* MOPPP
* MOPVP
* MPBP
* MPHP
* MPPP
* Naphyrone
* PEP
* Prolintane
* Pyrovalerone

Catecholamines
(and close relatives) |

* 6-FNE
* 6-OHDA
* a-Me-DA
* a-Me-TRA
* Adrenochrome
* Ciladopa
* D -DOPA (Dextrodopa)
* Dimetofrine
* Dopamine
* Epinephrine
* Epinine
* Etilefrine
* Ethylnorepinephrine
* Fenclonine
* Ibopamine
* Isoprenaline
* Isoetarine
* L -DOPA (Levodopa)
* L -DOPS (Droxidopa)
* L -Phenylalanine
* L -Tyrosine
* m-Tyramine
* Metanephrine
* Metaraminol
* Metaterol
* Metirosine
* Methyldopa
* N,N-Dimethyldopamine
* Nordefrin (Levonordefrin)
* Norepinephrine
* Norfenefrine (m-Octopamine)
* Normetanephrine
* Orciprenaline
* p-Octopamine
* p-Tyramine
* Phenylephrine
* Synephrine

Miscellaneous|

* AL-LAD
* Amidephrine
* Arbutamine
* Cafedrine
* Denopamine
* Desvenlafaxine
* Diphenidine
* Dizocilpine
* Dobutamine
* Dopexamine
* Ephenidine
* Etafedrine
* ETH-LAD
* Famprofazone
* Fluorolintane
* Hexapradol
* IP-LAD
* Lysergic acid amide
* Lysergic acid 2-butyl amide
* Lysergic acid 2,4-dimethylazetidide
* Lysergic acid diethylamide
* Methoxamine
* Methoxphenidine
* MT-45
* PARGY-LAD
* Phenibut
* PRO-LAD
* Pronethalol
* Salbutamol (Levosalbutamol)
* Solriamfetol
* Theodrenaline
* Thiamphenicol
* UWA-101

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Original source: https://en.wikipedia.org/wiki/MEAI. Read more

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*[EC50]: half-maximal effective concentration
*[ND]: No data
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*[DRAs]: Dopamine releasing agents
*[NRAs]: Norepinephrine releasing agents
*[SRAs]: Serotonin releasing agents