Merigolix

Merigolix (INN; developmental code names HS-10518, NCE-403, SKI-2670, TU-2670) is a gonadotropin releasing hormone (GnRH) antagonist which is under development for the treatment of endometriosis and uterine fibroids.[1][2][3][4][5] It is taken by mouth.[1] The drug is being developed by TiumBio, Daewon Pharmaceutical, and Jiangsu Hansoh Pharmaceutical.[1][2] As of October 2024, it is in phase 2 clinical trials for both endometriosis and uterine fibroids.[1][2]

## See also

* List of investigational sex-hormonal agents

## References

1. ↑ 1.0 1.1 1.2 1.3 "Merigolix". 28 October 2024. https://adisinsight.springer.com/drugs/800065270.
2. ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on Merigolix with Synapse". 22 February 2025. https://synapse.patsnap.com/drug/b6fc8cc4b81242688c2bee2d9d3f9726.
3. ↑ "Recent Development of Non-Peptide GnRH Antagonists". Molecules 22 (12): 2188. December 2017. doi:10.3390/molecules22122188. PMID 29232843.
4. ↑ "Uterine fibroids: an update on current and emerging medical treatment options". Therapeutics and Clinical Risk Management 15: 157–178. 2019. doi:10.2147/TCRM.S147318. PMID 30774352.
5. ↑ "Highlights on Medical Treatment of Uterine Fibroids". Current Pharmaceutical Design 27 (36): 3821–3832. 2021. doi:10.2174/1381612826666210101152820. PMID 33388011.

* v
* t
* e

GnRH and gonadotropin receptor modulators

GnRH|

* Agonists: Peptides: Alarelin
* Avorelin
* Azagly-nafarelin
* Buserelin
* Deslorelin
* Fertirelin
* GnRH
* Gonadorelin
* Goserelin
* Histrelin
* Leuprorelin (leuprolide)
* Lutrelin
* Nafarelin
* Peforelin
* Salmon GnRH
* Triptorelin
* Zoptarelin
* Zoptarelin doxorubicin

* Antagonists: Peptides: Abarelix
* Acyline
* Azaline B
* Cetrorelix
* Degarelix
* Detirelix
* Ganirelix
* Iturelix (antide)
* LXT-101
* Ornirelix (ornitide)
* Ozarelix
* Prazarelix
* Ramorelix
* Teverelix (antarelix); Non-peptides: Elagolix
* Linzagolix
* Opigolix
* Relugolix
* Sufugolix

Gonadotropin|

| LH/hCG|

* Agonists: Peptides: Choriogonadotropin alfa
* Human chorionic gonadotropin
* Luteinizing hormone
* Lutropin alfa
* Menotropin (human menopausal gonadotropin)

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FSH|

* Agonists: Peptides: Corifollitropin alfa
* Follicle-stimulating hormone
* Follitropin alfa
* Follitropin beta
* Follitropin epsilon
* Menotropin (human menopausal gonadotropin)
* Urofollitropin
* Varfollitropin alfa

* NAMs: Non-peptides: ADX-61623

* See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators • GnRH and gonadotropins

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*[INN]: International Nonproprietary Name
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*[t]: Discuss this template
*[e]: Edit this template
*[GnRH]: Gonadotropin-releasing hormone receptor
*[LH/hCG]: Luteinizing hormone/choriogonadotropin receptor
*[FSH]: Follicle-stimulating hormone receptor
*[NAMs]: negative allosteric modulators