Metixene

Short description: Chemical compound

Metixene

Clinical data
AHFS/Drugs.com| International Drug Names
ATC code|

* N04AA03 (WHO)

Legal status
Legal status|

* BR: Class C1 (Other controlled substances)

Identifiers

IUPAC name

* 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine

CAS Number|

* 4969-02-2 Y

PubChem CID|

* 4167

IUPHAR/BPS|

* 7232

DrugBank|

* DB00340

ChemSpider|

* 4023

UNII|

* 32VY6L26ZW

KEGG|

* D08209

ChEBI|

* CHEBI:51024

ChEMBL|

* ChEMBL1201342

Chemical and physical data
Formula| C20H23NS
Molar mass| 309.47 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24

InChI

* InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3

* Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N

NY (what is this?) (verify)

Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.[1] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases. [2]

## See also

* 3-Quinuclidinyl thiochromane-4-carboxylate
* Dothiepin

## References

1. ↑ "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. 1999. p. 178. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA178.
2. ↑ Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. doi:10.1172/JCI161142. PMID 37847564. PMC 10721147. https://www.jci.org/articles/view/161142. Retrieved 3 November 2023.

* v
* t
* e

Antiparkinson agents (N04)

Dopaminergics|

| DA precursor]]s|

* Levodopa#
* Melevodopa

|

DA receptor agonists|

* Apomorphine
* Bromocriptine
* Cabergoline
* Dihydroergocryptine
* Lisuride
* Pergolide
* Piribedil
* Pramipexole
* Ropinirole
* Rotigotine

MAO-B inhibitors|

* Rasagiline
* Safinamide
* Selegiline

COMT inhibitors|

* Entacapone
* Opicapone
* Tolcapone

AAAD inhibitors|

* Benserazide
* Carbidopa#

Anticholinergics|

* Benzatropine
* Biperiden#
* Bornaprine
* Chlorphenoxamine
* Cycrimine
* Dexetimide
* Diphenhydramine
* Etanautine
* Etybenzatropine
* Mazaticol
* Metixene
* Orphenadrine
* Phenglutarimide
* Piroheptine
* Procyclidine
* Profenamine
* Trihexyphenidyl
* Tropatepine

Others|

* Amantadine
* Budipine
* Methylxanthines (e.g., caffeine)
* Rimantadine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Muscarinic acetylcholine receptor modulators

mAChRs|

| Agonists|

* 77-LH-28-1
* AC-42
* AC-260,584
* Aceclidine
* Acetylcholine
* AF30
* AF150(S)
* AF267B
* Alvameline
* AQRA-741
* Arecoline
* Bethanechol
* Bevonium
* Butyrylcholine
* Carbachol
* CDD-0034
* CDD-0078
* CDD-0097
* CDD-0098
* CDD-0102
* Cevimeline
* Choline
* cis-Dioxolane
* Clozapine
* Desmethylclozapine (norclozapine)
* Ethoxysebacylcholine
* Itameline
* LY-593,039
* L-689,660
* LY-2,033,298
* McNA343
* Methacholine
* Milameline
* Muscarine
* NGX-267
* Ocvimeline
* Oxotremorine
* PD-151,832
* Pilocarpine
* RS86
* Sabcomeline
* SDZ 210-086
* Sebacylcholine
* Suberyldicholine
* Talsaclidine
* Tazomeline
* Thiopilocarpine
* Vedaclidine
* VU-0029767
* VU-0090157
* VU-0152099
* VU-0152100
* VU-0238429
* WAY-132,983
* Xanomeline
* YM-796

|

Antagonists|

* 3-Quinuclidinyl benzilate
* 4-DAMP
* Aclidinium bromide (+formoterol)
* Abediterol
* AF-DX 250
* AF-DX 384
* Ambutonium bromide
* Anisodamine
* Anisodine
* Antihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine, clemastine, cyproheptadine, dimenhydrinate, [[Chemistry:Dimetdimetindene, Diphenhydramine|diphenhydramine]], doxylamine, meclizine, mepyramine (pyrilamine), mequitazine, perlapine, phenindamine, pheniramine, Phenyltoloxamine|Phenyltoloxamine]]]], promethazine, propiomazine, triprolidine)
* AQ-RA 741
* Atropine
* Atropine methonitrate
* Atypical antipsychotics (e.g., clozapine, Chemistry:Fluperlapine

Precursors
(and prodrugs)|

* Acetyl-coA
* Adafenoxate
* Choline (lecithin)
* Citicoline
* Cyprodenate
* Dimethylethanolamine
* Glycerophosphocholine
* Meclofenoxate (centrophenoxine)
* Phosphatidylcholine
* Phosphatidylethanolamine
* Phosphorylcholine
* Pirisudanol

See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators

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*[BR]: Brazil
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*[mAChRs]: Muscarinic acetylcholine receptors