Moperone

Short description: Chemical compound

Moperone

Clinical data
Trade names| Luvatren (discontinued)
ATC code|

* N05AD04 (WHO)

Legal status
Legal status|

* BR: Class C1 (Other controlled substances)

Identifiers

IUPAC name

* 1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one

CAS Number|

* 1050-79-9

PubChem CID|

* 4249

DrugBank|

* DB13554

ChemSpider|

* 4100

UNII|

* OU730881W5

KEGG|

* D02623

Chemical and physical data
Formula| C22H26FNO2
Molar mass| 355.453 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CC1=CC=C(C=C1)C1(O)CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

InChI

* InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3

* Key:AGAHNABIDCTLHW-UHFFFAOYSA-N

Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class[1] which is marketed in Japan for the treatment of schizophrenia. It is an antagonist for the D2 (Ki 0.7–1.9 nM), D3 (Ki 0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors.[2][3]

## References

1. ↑ "The clinical position of moperone among the butyrophenones". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry 23 (1): 4–9. 1969. doi:10.3109/08039486909132154. PMID 5354545.
2. ↑ "Moperone". Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. 2010. pp. 798. doi:10.1007/978-3-540-68706-1_1838. ISBN 978-3-540-68706-1. https://doi.org/10.1007/978-3-540-68706-1_1838. Retrieved 21 March 2022.
3. ↑ "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. https://pdsp.unc.edu/databases/pdsp.php?receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=moperone&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query.

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* t
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Antipsychotics (N05A)

Typical|

* Butyrophenones: Benperidol
* Bromperidol
* Droperidol
* Haloperidol#
* Moperone
* Pipamperone
* Spiperone
* Timiperone
* Trifluperidol

* Diphenylbutylpiperidines: Fluspirilene
* Penfluridol
* Pimozide

* Phenothiazines: Acetophenazine
* Butaperazine
* Carphenazine (carfenazine)‡
* Chlorpromazine
* Cyamemazine
* Dixyrazine
* Fluphenazine
* Levomepromazine (methotrimeprazine)
* Mesoridazine
* Perazine
* Periciazine
* Perphenazine
* Piperacetazine
* Pipotiazine
* Prochlorperazine
* Promazine
* Sulforidazine
* Thiopropazate
* Thioproperazine
* Thioridazine
* Trifluoperazine
* Triflupromazine

* Thioxanthenes: Chlorprothixene
* Clopenthixol
* Flupentixol
* Tiotixene (thiothixene)
* Zuclopenthixol

Disputed|

* Benzamides: Amisulpride
* Levosulpiride
* Nemonapride
* Remoxipride‡
* Sulpiride
* Sultopride
* Tiapride
* Veralipride‡

* Butyrophenones: Melperone

* Tricyclics: Carpipramine
* Clocapramine
* Clorotepine
* Clotiapine
* Loxapine
* Mosapramine

* Others: Molindone

Atypical|

* Benzisoxazole/benzisothiazoles: Iloperidone
* Lurasidone
* Paliperidone
* Paliperidone palmitate
* Perospirone
* Risperidone#
* Ziprasidone

* Butyrophenones: Lumateperone†

* Phenylpiperazines/quinolinones: Aripiprazole
* Aripiprazole lauroxil
* Brilaroxazine†
* Brexpiprazole
* Cariprazine

* Tricyclics: Asenapine
* Clozapine#
* Olanzapine
* Quetiapine
* Zotepine

* Others: Blonanserin
* Pimavanserin
* Sertindole

Others|

* Azacyclonol
* Cannabidiol
* Oxypertine
* Reserpine
* Tetrabenazine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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