OSS-128167

OSS-128167 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has pro-inflammatory effects and accelerates cellular aging, however it shows anti-viral and anti-cancer properties which are useful in research, and has also demonstrated potential medical applications for SIRT6 inhibitors such as in the treatment of some forms of asthma.[1][2][3][4][5]

## References

1. ↑ "SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α". Frontiers in Pharmacology 10. 2019. doi:10.3389/fphar.2019.01270. PMID 31708789.
2. ↑ "Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling". Journal of Experimental & Clinical Cancer Research 39 (1). July 2020. doi:10.1186/s13046-020-01623-w. PMID 32711549.
3. ↑ "SIRT6‑specific inhibitor OSS‑128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress". Molecular Medicine Reports 23 (5). May 2021. doi:10.3892/mmr.2021.12006. PMID 33760202.
4. ↑ "Downregulation of Sirt6 by CD38 promotes cell senescence and aging". Aging 14 (23): 9730–9757. December 2022. doi:10.18632/aging.204425. PMID 36490326.
5. ↑ "Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling". Nature Communications 14 (1). December 2023. doi:10.1038/s41467-023-44179-x. PMID 38135684. Bibcode: 2023NatCo..14.8525Q.

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