Olorofim

Short description: Chemical compound

Olorofim

Clinical data
Other names| F901318
Legal status
Legal status|

* Investigational

Identifiers

IUPAC name

* 2-(1,5-Dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide

CAS Number|

* 1928707-56-5

PubChem CID|

* 91885568

UNII|

* T34SH2H9HI

Chemical and physical data
Formula| C28H27FN6O2
Molar mass| 498.562 g·mol−1

Olorofim (F901318) is an experimental antifungal drug being developed for invasive mold infections.[1][2] If approved it would be a first-in-class medication (for the orotomide class). In 2023, the FDA decided not to approve the drug and to request more data about the safety of the drug.[3] Olorofim does not inhibit growth of Candida species.[2]

## References

1. ↑ Neoh, Chin Fen; Jeong, Wirawan; Kong, David CM; Slavin, Monica A (2023). "The antifungal pipeline for invasive fungal diseases: what does the future hold?". Expert Review of Anti-infective Therapy 21 (6): 577–594. doi:10.1080/14787210.2023.2203383. PMID 37057677.
2. ↑ 2.0 2.1 Wiederhold, Nathan P. (2020). "Review of the Novel Investigational Antifungal Olorofim". Journal of Fungi 6 (3): 122. doi:10.3390/jof6030122. ISSN 2309-608X. PMID 32751765.
3. ↑ "FDA Passes on Olorofim Despite Critical Need for Antifungals" (in en). https://www.medscape.com/viewarticle/993520.

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*[CID]: Compound ID