Pimodivir

Pimodivir (VX-787, JNJ-63623872) is an antiviral drug which was developed as a treatment for influenza. It acts as an inhibitor of influenza virus polymerase basic protein 2, and has shown promising results in Phase II clinical trials.[1][2][3] However, in late 2021, Janssen announced that the clinical development of pimidivir had been halted due to lack of benefit over standard of care.[4]

## See also

* Baloxavir marboxil
* Favipiravir
* Galidesivir
* Nitazoxanide
* Onradivir
* Oseltamivir
* Peramivir
* Remdesivir
* Ribavirin
* Triazavirin
* Umifenovir
* Zanamivir

## References

1. ↑ "Pimodivir treatment in adult volunteers experimentally inoculated with live influenza virus: a Phase IIa, randomized, double-blind, placebo-controlled study". Antiviral Therapy 23 (4): 335–344. 2018. doi:10.3851/IMP3212. PMID 29244026.
2. ↑ "Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial". The Journal of Infectious Diseases 219 (7): 1026–1034. March 2019. doi:10.1093/infdis/jiy547. PMID 30428049.
3. ↑ "Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference". Antiviral Research 167: 45–67. July 2019. doi:10.1016/j.antiviral.2019.04.006. PMID 30974127.
4. ↑ "Janssen's lead coronavirus vaccine shows preclinical promise". 4 September 2020. https://www.pharmatimes.com/news/janssens_lead_coronavirus_vaccine_shows_preclinical_promise_1348249.

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* t
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[[Biology:RNA RNA virus Antiviral drug|antivirals]] (primarily J05, also S01AD and D06BB)

Hepatitis C|

| NS3/4A protease inhibitors (–previr)|

* Asunaprevir
* Boceprevir‡
* Ciluprevir§
* Danoprevir†
* Faldaprevir‡
* Glecaprevir
* Grazoprevir
* Narlaprevir
* Paritaprevir
* Simeprevir#
* Sovaprevir†
* Telaprevir‡
* Vaniprevir
* Vedroprevir§
* Voxilaprevir

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NS5A inhibitors (–asvir)|

* Daclatasvir#
* Elbasvir
* Ledipasvir
* Odalasvir†
* Ombitasvir
* Pibrentasvir
* Ravidasvir†
* Ruzasvir†
* Samatasvir†
* Velpatasvir

NS5B RNA polymerase inhibitors (–buvir)|

* Beclabuvir†
* Dasabuvir#
* Deleobuvir§
* Filibuvir§
* Setrobuvir§
* Sofosbuvir#
* Radalbuvir†
* Uprifosbuvir†

Combination drugs|

* Elbasvir/grazoprevir
* Glecaprevir/pibrentasvir
* Ledipasvir/sofosbuvir#
* Ombitasvir/paritaprevir/ritonavir#
* Sofosbuvir/daclatasvir
* Sofosbuvir/velpatasvir/voxilaprevir
* Velpatasvir/sofosbuvir

Picornavirus|

* viral entry: Pleconaril†

Anti-influenza agents|

* Umifenovir

* adamantane derivatives/M2 inhibitors (Adapromine
* Amantadine
* Rimantadine)

* neuraminidase inhibitors/release phase (Oseltamivir<sup>#
* Zanamivir
* Peramivir, Laninamivir†)

Multiple/general|

| Interferon|

* Interferon alfa 2b
* Peginterferon alfa-2a#

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Multiple/unknown|

* Favipiravir
* Galidesivir†
* Remdesivir†
* Mericitabine†
* MK-608§
* NITD008§
* Moroxydine
* Ribavirin#/Taribavirin†
* Triazavirin

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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