STING-IN-2

STING-IN-2 (C-170) is an experimental drug which acts as an irreversible antagonist of the stimulator of interferon genes (STING) protein. It has antiinflammatory, antiviral and potential anti-cancer effects by reducing cytokine signalling, and has potential application in numerous disease states in which inflammation plays a role.[1][2][3][4][5]

## See also

* H-151
* SN-011

## References

1. ↑ "Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair". Cell Metabolism 33 (10): 2076–2089.e9. October 2021. doi:10.1016/j.cmet.2021.07.009. PMID 34343500.
2. ↑ "Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy". Journal of Medicinal Chemistry 65 (9): 6593–6611. May 2022. doi:10.1021/acs.jmedchem.1c01948. PMID 35452223.
3. ↑ "Marine diterpenoid targets STING palmitoylation in mammalian cells". Communications Chemistry 6 (1): 153. July 2023. doi:10.1038/s42004-023-00956-9. PMID 37463995. Bibcode: 2023CmChe...6..153H.
4. ↑ "CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA". Gut Microbes 16 (1). 2024. doi:10.1080/19490976.2024.2379633. PMID 39024479.
5. ↑ "Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling". Advanced Science 11 (20). May 2024. doi:10.1002/advs.202308131. PMID 38498770.

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