Sandalore

Sandalore is a synthetic sandalwood odorant[1][2] with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar brahmanol, have been identified as agonists of the cutaneous olfactory receptor OR2AT4, and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect.

## References

1. ↑ Busse, Daniela; Kudella, Philipp; Grüning, Nana-Maria; Gisselmann, Günter; Ständer, Sonja et al. (2014). "A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4". Journal of Investigative Dermatology 134 (11): 2823–2832. doi:10.1038/jid.2014.273. PMID 24999593. http://www.jidonline.org/article/S0022202X15365386/pdf.
2. ↑ "Skin's ability to 'smell' seems to help it heal itself". New Scientist. 8 July 2014. https://www.newscientist.com/article/dn25865-skins-ability-to-smell-seems-to-help-it-heal-itself/.

## External links

* Jimenez, Francisco; López, Esmeralda; Bertolini, Marta; Alam, Majid; Chéret, Jérémy et al. (2021). "Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore, improves telogen effluvium‐associated parameters". Journal of Cosmetic Dermatology 20 (3): 784–791. doi:10.1111/jocd.13608. ISSN 1473-2130. https://onlinelibrary.wiley.com/doi/10.1111/jocd.13608. Retrieved 19 October 2025. Clinical trial on effect of Sandalore on hair loss.

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