Sandalore

Names
Preferred IUPAC name

3-Methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol

Other names

Sandal pentanol

Identifiers

CAS Number

* 65113-99-7

3D model (JSmol)

* Interactive image

ChemSpider |

* 93216

EC Number |

* 265-453-0

PubChem CID

* 103212

UNII |

* 1XL3NL51UU

InChI

* InChI=1S/C14H26O/c1-10(12(3)15)6-8-13-9-7-11(2)14(13,4)5/h7,10,12-13,15H,6,8-9H2,1-5H3

Key: NGYMOTOXXHCHOC-UHFFFAOYSA-N

SMILES

* CC1=CCC(C1(C)C)CCC(C)C(C)O

Properties

Chemical formula

| C14H26O
Molar mass | 210.361 g·mol−1
Hazards
GHS pictograms |
GHS Signal word | Warning

GHS hazard statements

| H319, H411

GHS precautionary statements

| P264, P273, P280, P305+351+338, P337+313, P391, P501

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Tracking categories (test):

* SizeSet

Sandalore is a synthetic sandalwood odorant[1][2] with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar brahmanol, have been identified as agonists of the cutaneous olfactory receptor OR2AT4, and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect.

## References

1. ↑ Daniela Busse, Philipp Kudella, Nana-Maria Grüning, Günter Gisselmann1, Sonja Ständer, Thomas Luger, Frank Jacobsen, Lars Steinsträßer, Ralf Paus, Paraskevi Gkogkolou, Markus Böhm, Hanns Hatt and Heike Benecke (2014). "A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4". Journal of Investigative Dermatology 134 (11): 2823–2832. doi:10.1038/jid.2014.273. PMID 24999593.
2. ↑ "Skin's ability to 'smell' seems to help it heal itself". New Scientist. 8 July 2014. https://www.newscientist.com/article/dn25865-skins-ability-to-smell-seems-to-help-it-heal-itself/.

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*[CID]: Compound ID
*[H319]: Causes serious eye irritation
*[H411]: Toxic to aquatic life with long lasting effects
*[P264]: Wash … thoroughly after handling
*[P273]: Avoid release to the environment
*[P280]: Wear protective gloves/protective clothing/eye protection/face protection
*[P305+351+338]: IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing
*[P337+313]: Get medical advice/attention
*[P391]: Collect spillage
*[P501]: Dispose of contents/container to …