TH-PVP

Short description: Chemical compound

TH-PVP

Clinical data
ATC code|

* None

Legal status
Legal status|

* BR: F2
* CA: Schedule I
* DE: NpSG (Industrial and scientific use only)
* UK: Under Psychoactive Substances Act

Identifiers

IUPAC name

* 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one

CAS Number|

* 2304915-07-7 Y

PubChem CID|

* 132989549

ChemSpider|

* 82954253

UNII|

* S5MU9GV87C

Chemical and physical data
Formula| C19H27NO
Molar mass| 285.431 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CCCC(C(=O)C1=CC2=C(CCCC2)C=C1)N3CCCC3

InChI

* InChI=1S/C19H27NO/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17/h10-11,14,18H,2-9,12-13H2,1H3

* Key:MMIKQWIZKBYLKZ-UHFFFAOYSA-N

TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,[1] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.[2][3][4][5][6][7] Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin,[8] but it failed to produce stimulant effects in animals,[9] and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.

## See also

* 4-Et-PVP
* 6-APT
* EDMA
* Indapyrophenidone
* Naphyrone
* O-2390

## References

1. ↑ "EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA". http://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf.
2. ↑ "Identification and derivatization of selected cathinones by spectroscopic studies". Forensic Science International 266: 416–426. September 2016. doi:10.1016/j.forsciint.2016.06.034. PMID 27423024.
3. ↑ "Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances". Journal of Chromatography A 1574: 91–100. November 2018. doi:10.1016/j.chroma.2018.09.006. PMID 30220430.
4. ↑ "Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population". Drug Testing and Analysis 10 (3): 539–547. March 2018. doi:10.1002/dta.2232. PMID 28640970.
5. ↑ "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone.". Forensic Toxicol 37 (2): 288–307. July 2019. doi:10.1007/s11419-018-00463-w.
6. ↑ "New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey". Forensic Science International 294: 113–123. January 2019. doi:10.1016/j.forsciint.2018.11.003. PMID 30502695.
7. ↑ "New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study.". Forensic Science International 306: 110002. 24 October 2019. doi:10.1016/j.forsciint.2019.110002. PMID 31864775.
8. ↑ "Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology 236 (3): 939–952. March 2019. doi:10.1007/s00213-018-5059-5. PMID 30397775.
9. ↑ "Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats". Drug and Alcohol Dependence 199: 50–58. June 2019. doi:10.1016/j.drugalcdep.2019.02.016. PMID 30986635.

* v
* t
* e

Empathogens/entactogens

Phenylalkyl-
amines
(other than
cathinones)|

* Unfused benzene ring: 3-CMA
* 4-CAB
* 4-FA
* 4-MA
* 4-MMA
* 4-FMA
* 4-MTA
* 4,4'-DMAR
* Ariadne
* Metaescaline
* MMA
* PMA
* PMEA
* PMMA
* mMMA
Benzodioxine: EDMA
Benzodioxoles: Phenethylamine: { Lophophine }
* Amphetamines: { 2-Methyl-MDA
* 2,3-MDA
* 3,4-MDA (tenamfetamine)
* 5-Methyl-MDA
* 6-Methyl-MDA
* DiFMDA
* DMMDA
* DMMDA-2
* EIDA
* MDEA
* MDMA (midomafetamine)
* MDMOH
* MDOH
* MMDA
* MMDA-2
* MMDMA }
* 1-Phenylbutan-2-amines: { BDB
* EBDB
* MBDB }
* Phentermines: { MDMP
* MDPH }
Benzofurans and dihydrobenzofurans: 5-APB
* 5-APDB
* 5-EAPB
* 5-MAPB
* 5-MAPDB
* 5-MBPB
* 6-APB
* 6-APDB
* 6-EAPB
* 6-MAPB
* 6-MAPDB
* IBF5MAP
Indanes: 5-APDI
* 5-MAPDI
Indoles: 5-IT
* 6-API
Naphthalenes: Methamnetamine
* Naphthylaminopropane
Tetralin: 6-APT

Cyclized phenyl-
alkylamines|

* Aminoindanes: 5-IAI
* AMMI
* ETAI
* MDAI
* MDMAI
* MMAI
* MEAI
* NM-2-AI
* TAI
Aminotetralins: 6-CAT
* MDAT
* MDMAT

Cathinones|

* 3-MMC
* 4-EMC
* Brephedrone
* Butylone
* Ethylone
* Eutylone
* Flephedrone
* Mephedrone
* Methedrone
* Methylone
* TH-PVP

Tryptamines|

* 4-Methyl-αET
* αET
* αMT

Chemical classes|

* Substituted amphetamine
* Sub. benzofuran
* Sub. cathinone
* Sub. MDPEA
* Sub. PEA
* Sub. tryptamine

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