TM5441

Short description: Chemical compound

TM5441

Clinical data
ATC code|

* None

Identifiers

IUPAC name

* 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid

CAS Number|

* 1190221-43-2

PubChem CID|

* 44250349

ChemSpider|

* 60598824

ChEMBL|

* ChEMBL4204253

Chemical and physical data
Formula| C21H17ClN2O6
Molar mass| 428.83 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* C1=CC(=CC(=C1)NC(=O)COCC(=O)NC2=C(C=C(C=C2)Cl)C(=O)O)C3=COC=C3

InChI

* InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28)

* Key:BGGMLMAPVODXAU-UHFFFAOYSA-N

TM5441 is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1). By inhibiting PAI-1, it increases activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. It has been researched for conditions such as hepatic steatosis and diabetic nephropathy, and while it has not been developed for medical use, it is widely used in scientific research.[1][2][3][4]

## References

1. ↑ "Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model". PLOS ONE 11 (6): e0157012. 2016. doi:10.1371/journal.pone.0157012. PMID 27258009. Bibcode: 2016PLoSO..1157012J.
2. ↑ "PAI-1 is a critical regulator of FGF23 homeostasis". Science Advances 3 (9): e1603259. September 2017. doi:10.1126/sciadv.1603259. PMID 28924605. Bibcode: 2017SciA....3E3259E.
3. ↑ "Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance". Frontiers in Pharmacology 11: 943. 2020. doi:10.3389/fphar.2020.00943. PMID 32670063.
4. ↑ "Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury". Inflammation 44 (6): 2499–2517. December 2021. doi:10.1007/s10753-021-01520-0. PMID 34460025. https://www.researchsquare.com/article/rs-479179/latest.pdf.

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*[CID]: Compound ID