VU6036864

Identifiers

IUPAC name

* 5-[4-(7-chloro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,2,6,6-tetradeuteriopiperidin-1-yl]sulfonyl-2-methyl-1,3-oxazole

CAS Number|

* 2746406-36-8

PubChem CID|

* 162361022

Chemical and physical data
Formula| C15H12ClD4N5O3S
Molar mass| 385.86 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* [2H]C1(CC(CC(N1S(=O)(=O)C2=CN=C(O2)C)([2H])[2H])C3=CN4C(=NC=N4)C=C3Cl)[2H]

InChI

* InChI=1S/C15H16ClN5O3S/c1-10-17-7-15(24-10)25(22,23)20-4-2-11(3-5-20)12-8-21-14(6-13(12)16)18-9-19-21/h6-9,11H,2-5H2,1H3/i4D2,5D2

* Key:URAUBDCJGRESTK-CQOLUAMGSA-N

VU6028418 is an experimental drug that acts as a potent and selective antagonist of the Muscarinic acetylcholine receptor M5. It has superior potency and selectivity compared to older ligands for this receptor and will be useful to characterise its effects, which have previously been difficult to separate from other muscarinic acetylcholine receptors.[1]

## References

1. ↑ "Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor". Journal of Medicinal Chemistry 67 (16): 14394–14413. August 2024. doi:10.1021/acs.jmedchem.4c01193. PMID 39105778.

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*[CID]: Compound ID