WYE-687

Short description: Chemical compound

WYE-687

Identifiers

IUPAC name

* methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate

CAS Number|

* 1062161-90-3

PubChem CID|

* 25229450

ChemSpider|

* 24626255

ChEMBL|

* ChEMBL561103

Chemical and physical data
Formula| C28H32N8O3
Molar mass| 528.617 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6

InChI

* InChI=1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37)

* Key:VDOCQQKGPJENHJ-UHFFFAOYSA-N

WYE-687 is a drug which acts as an inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in the treatment of various forms of cancer.[1][2][3]

## References

1. ↑ "Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin". Cancer Research 69 (15): 6232–40. August 2009. doi:10.1158/0008-5472.CAN-09-0299. PMID 19584280.
2. ↑ "Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent". Biochemical and Biophysical Research Communications 470 (2): 324–330. February 2016. doi:10.1016/j.bbrc.2016.01.054. PMID 26792718.
3. ↑ "Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo". PLOS ONE 12 (3): e0172555. 2017. doi:10.1371/journal.pone.0172555. PMID 28257457. Bibcode: 2017PLoSO..1272555P.

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*[CID]: Compound ID