AbbVie Inc.

Short description: US pharmaceutical company

AbbVie Inc.

Type| Public

Traded as

| NYSE: ABBV
S&P 100 component
S&P 500 component
Industry| Biopharmaceutical
Founded| 2013; 10 years ago (2013)
Headquarters| Lake Bluff, Illinois, United States

Area served

| Worldwide
(170+ Countries)

Key people

| Richard A. Gonzalez
(Chairman & CEO)
Products| Pharmaceutical drugs

* Humira (adalimumab)
* Imbruvica (ibrutinib)
* Venclexta (venetoclax)
* Zinbryta (daclizumab)
* Kaletra (lopinavir)
* Norvir (ritonavir)
* Mavyret/Maviret (glecaprevir/pibrentasvir)

Revenue|  US$32.753 billion (2018)[1]

Operating income

|  US$6.383 billion (2018)[1]

Net income

|  US$5.687 billion (2018)[1]
Total assets|  US$59.352 billion (2018)[1]
Total equity|  US$−8.446 billion (2018)[1]

Number of employees

| ~30,000 (January 2019)[1]
Website| abbvie.com

AbbVie is an American publicly traded biopharmaceutical company founded in 2013. It originated as a spin-off of Abbott Laboratories.

## Contents

* 1 History
* 2 Acquisitions
* 2.1 Acquisition history
* 3 Collaboration
* 4 Products
* 5 References
* 6 External links

## History

On October 19, 2011, Abbott Laboratories announced its plan to separate into two publicly traded companies. The "new" Abbott Laboratories would specialize in diversified products including medical devices, diagnostic equipment and nutrition products, while AbbVie would operate as a research-based pharmaceutical manufacturer.[2] The separation was effective January 1, 2013, and AbbVie was officially listed on the New York Stock Exchange (ABBV) on January 2, 2013.[3]

According to Miles White, CEO at the time, the purpose of the split was to allow markets to value the two businesses separately; White said that investors would "benefit from two fundamentally different investment opportunities with distinct strategic profiles and business priorities."[4] Some investors were concerned that the split was done to protect the value of the device business from the loss of value facing the drug division due to the imminent expiration of patents on Humira, which accounted for about half of the drug division's revenue.[4]

As of December 2015, the company employed in excess of 28,000 globally, and provided products to individuals in more than 170 countries.[5]

## Acquisitions

In January 2014, the company acquired ImmuVen for an undisclosed sum.[6] On September 3, 2014, AbbVie and Infinity Pharmaceuticals announced that they had entered into a global collaboration to develop and commercialize duvelisib, Infinity's PI3K inhibitor for the treatment of patients with cancer. On the same day, AbbVie and Calico announced that they had entered into a R&D collaboration intended to discover, develop and bring to market new therapies for patients with age-related diseases including neurodegeneration and cancer. Calico (California Life Company) is an Alphabet Inc. subsidiary led by Arthur D. Levinson (former Chairman and CEO of Genentech) and Hal V. Barron (former Executive Vice President and Chief Medical Officer of Genentech) that is focused on aging and age-related diseases.[7]

In October 2014, after a long negotiation, AbbVie stopped its efforts to acquire Shire, which would have been one of the largest M&A deals of that year and one of the largest tax inversions in history, due to changes in the US tax code by the US Treasury; AbbVie had to pay a $1.6 billion breakup fee.[8]

On March 4, 2015, AbbVie announced its agreement to acquire the oncology firm Pharmacyclics and its treatment for blood cancers, ibrutinib; AstraZeneca had also been bidding to acquire Pharmacyclics.[9][10] Under the terms of the transaction, AbbVie agreed to pay $261.25 per share as a mix of cash and AbbVie equity. The acquisition valued at approximately $21 billion was completed on May 26, 2015.[11] The Pharmacyclics name was retained, and it operates as a subsidiary of AbbVie from its previous Sunnyvale, California, headquarters.[12] On June 3, 2015, AbbVie and Halozyme Therapeutics announced that they had entered into a global collaboration and licensing agreement to develop and commercialize products that combine AbbVie’s treatments and Halozyme’s ENHANZE drug-delivery technology, this was terminated in November 2016.[13]

On 28 April 2016, the company announced it would acquire Stemcentrx for up to $9.8 billion.[14] A day later, the company announced an expansion of a two and a half-year-old cystic fibrosis deal with Galapagos, potentially doubling milestone payments to $600 million.[15]

On 25 June 2019, AbbVie announced it would acquire Irish-based Allergan plc for about $63 billion; however the transaction would not be structured as a tax inversion, and that post the transaction, AbbVie (and the group) would remain legally domiciled in the U.S. for tax purposes.[16][17] In July, the company announced it would acquire Mavupharma, boosting its cancer drug pipeline.[18][19]

### Acquisition history

Template:Hidden start

* Abbvie (Spun of from Abbott Laboratories)
* Pharmacyclics (Acq 2015)
* Stemcentrx (Acq 2016)
* Venice Subsidiary LLC[20]
* Allergan, plc (Acq 2019)
* Allergan, inc
* MAP Pharmaceuticals Inc (Acq 2013)
* Kythera Biopharmaceuticals (Acq 2015)
* Actavis plc
* Eden Biodesign
* Watson Pharmaceuticals
* Warner Chilcott Plc (Acq 2000)
* Andrx Corporation (Acq 2006)
* Procter & Gamble (Prescription drug div, Acq 2009)
* Arrow Group (Acq 2009)
* Specifar Pharmaceuticals S.A. (Acq 2011)
* Ascent Pharmahealth Ltd (Acq 2012)
* Actavis Group (Acq 2012)
* Galen (Acq 2013)
* Uteron Pharma, S.A. (Acq 2013)
* Durata Therapeutics (Acq 2014)
* Silom Medical Company (Acq 2014)
* Forest Laboratories (Acq 2014)
* Aptalis Pharma
* Axcan Pharma
* Eurand Pharmaceuticals
* Furiex Pharmaceuticals Inc (Acq 2014)
* Auden Mckenzie Holdings Limited (Acq 2015)
* Oculeve, Inc (Acq 2015)
* Naurex Inc (Acq 2015)
* AqueSys (Acq 2015)
* Northwood Medical Innovation Ltd (Acq 2015)
* Topokine Therapeutics (Acq 2016)
* Vitae Pharmaceuticals, Inc (Acq 2016)
* Tobira Therapeutics (Acq 2016)
* ForSight VISION5 (Acq 2016)
* RetroSense Therapeutics (Acq 2016)
* Akarna Therapeutics (Acq 2016)
* Motus Therapeutics (Acq 2016)
* Chase Pharmaceuticals (Acq 2016)
* LifeCell (Acq 2016)
* Zeltiq Aesthetics Inc. (Acq 2017)
* Keller Medical, Inc (Acq 2017)
* Repros Therapeutics (Acq 2017)
* Envy Medical, Inc. (Acq 2019)
* Mavupharma (Acq 2019)

## Collaboration

On February 10, 2016, AbbVie and Cambridge, Massachusetts-based Synlogic announced a multi-year R&D collaboration. Synlogic is a synthetic biology company built on research from the labs of James Collins and Tim Lu at MIT. As part of the collaboration, AbbVie is getting worldwide rights to Synlogic’s probiotic-based technology for treating inflammatory bowel disease, and the research teams will focus on Crohn’s disease and ulcerative colitis.[21] In April 2016, the company partnered with the University of Chicago to investigate a number of areas of oncology: breast, lung, prostate, colorectal and hematological cancers.[22] In the same month the company announced it would co-commercialize Argenx's preclinical immunotherapy, ARGX-115. ARGX-115 is a first-in-class immunotherapy targeting GARP (glycoprotein A repetitions predominant), a membrane protein believed to enhance the immunosuppressive effects of T cells.[23] The company also announced a deal to co-develop/commercialize at least one of CytomX Probody's conjugates against CD71 (transferrin receptor 1).[24]

## Products

According to the Wall Street Journal as of January 2016 ibrutinib, a specialty drug, cost US$116,600 to $155,400 a year wholesale in the United States. In spite of discounts and medical insurance, the prohibitive price causes some patients to not fill their prescriptions.[25] AbbVie estimates global sales of the drug at $1 billion in 2016 and $5 billion in 2020.[25]

In 2018 it started litigation against NHS England in the Technology and Construction Court claiming that they breached procurement rules and had not treated the company fairly during what was described as "the single largest medicines procurement ever done by the NHS" when seeking suppliers for hepatitis C treatments.[26] In 2019, a UK court dismissed AbbVie's case against the NHS. [27]

As of 2019, the company remained committed to product development in the cystic fibrosis disease area, despite major success by their main competitor in the area, Vertex.[28]

## References

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "AbbVie Inc. 2018 Annual Report (Form 10-K)". U.S. Securities and Exchange Commission. February 2019. https://last10k.com/sec-filings/abbv#link_fullReport.
2. ↑ "Abbott Labs to Split Into 2 Companies". The New York Times. October 19, 2011. https://dealbook.nytimes.com/2011/10/19/abbott-to-split-into-two/?_r=0. Retrieved October 19, 2011.
3. ↑ "Abbott Completes Separation of Research-Based Pharmaceuticals Business". AbbVie Inc.. January 2, 2013. Archived from the original on January 14, 2013. https://web.archive.org/web/20130114034619/http://abbvie.mediaroom.com/2013-01-02-AbbVie-Celebrates-Launch-as-New-Biopharmaceutical-Company-with-Employees-Patients. Retrieved January 2, 2013.
4. ↑ 4.0 4.1 "More than splitting pills: Health care giant Abbott Laboratories ready to spin off AbbVie". Chicago Tribune. December 30, 2012. http://articles.chicagotribune.com/2012-12-30/business/ct-biz-1230-bf-abbott-spin-20121230_1_longtime-abbott-executive-abbvie-abbott-laboratories. Retrieved October 25, 2016.
5. ↑ "AbbVie - About Us". abbvie.com. http://www.abbvie.com/about-us/home.html. Retrieved 1 January 2016.
6. ↑ "AbbVie - Acquisitions - crunchbase". https://www.crunchbase.com/organization/abbvie/acquisitions.
7. ↑ "Google-Backed Calico Joins AbbVie in Up to $1.5B Collaboration". Genetic Engineering & Biotechnology News. September 3, 2014. http://www.genengnews.com/gen-news-highlights/google-backed-calico-joins-abbvie-in-up-to-1-5b-collaboration/81250303. Retrieved June 4, 2015.
8. ↑ Gelles, David (2014). "After Tax Inversion Rules Change, AbbVie and Shire Agree to Terminate Their Deal". The New York Times (Zacks Equity Research). https://dealbook.nytimes.com/2014/10/20/abbvie-and-shire-agree-to-terminate-their-deal/?_r=0.
9. ↑ Nisen, Max (2015). "AstraZeneca Chases AbbVie, Cheaply". Chicago Business (Crain's). http://www.chicagobusiness.com/article/20151217/NEWS03/151219843/astrazeneca-chases-abbvie-cheaply. Retrieved 31 December 2015.
10. ↑ Staff (1 April 2015). "AbVie Acquires Oncology Drug Firm Pharmacyclics for $21B". Genetic Engineering & Biotechnology News 35 (5): 10. http://www.genengnews.com/gen-news-highlights/abbvie-acquires-oncology-drug-firm-pharmacyclics-for-21b/81250997/.
11. ↑ Rockoff, Jonathan D.; Loftus, Peter (5 March 2015). "AbbVie to Buy Pharmacyclics in $21 Billion Deal". The Wall Street Journal. https://www.wsj.com/articles/abbvie-to-buy-pharmacyclics-in-21-billion-deal-1425528086. (Subscription content?)
12. ↑ "AbbVie (ABBV) Announces Completion of Pharmacyclics Acquisition". StreetInsider.com. May 26, 2015. http://www.streetinsider.com/Corporate+News/AbbVie+(ABBV)+Announces+Completion+of+Pharmacyclics+Acquisition/10594347.html. Retrieved June 5, 2015.
13. ↑ "Abbvie Terminates Development Deal with Halozyme - GEN". http://www.genengnews.com/gen-news-highlights/abbvie-terminates-development-deal-with-halozyme/81253454.
14. ↑ "AbbVie to Acquire Stemcentrx for Up to $9.8B". GEN. http://www.genengnews.com/gen-news-highlights/abbvie-to-acquire-stemcentrx-for-up-to-9-8b/81252666/.
15. ↑ "Galapagos, AbbVie Expand CF Collaboration to Up-to-$600M". GEN. http://www.genengnews.com/gen-news-highlights/galapagos-abbvie-expand-cf-collaboration-to-up-to-600m/81252672/.
16. ↑ Julia Kollewe (25 June 2019). "Botox maker Allergan bought by US drug giant for $63bn". https://www.theguardian.com/business/2019/jun/25/botox-maker-allergan-bought-by-us-drug-giant-abbvie-for-63bn. Retrieved 25 June 2019.
17. ↑ Rebecca Spalding; Riley Griffin (25 June 2019). "AbbVie Strikes $63 Billion Deal for Botox Maker Allergan". Bloomberg News. https://www.bloomberg.com/news/articles/2019-06-25/abbvie-in-63-billion-deal-to-buy-botox-maker-allergan. Retrieved 25 June 2019. "The deal will return Allergan to the U.S., at least for tax purposes."
18. ↑ "AbbVie Dives into STING and Boehringer Ingelheim Snaps Up Swiss-based AMAL". July 15, 2019. https://www.biospace.com/article/abbvie-dives-into-sting-and-boehringer-ingelheim-snaps-up-swiss-based-amal/.
19. ↑ "AbbVie Enhances Early Stage Oncology Pipeline with Acquisition of Mavupharma". July 15, 2019. https://www.biospace.com/article/abbvie-enhances-early-stage-oncology-pipeline-with-acquisition-of-mavupharma/.
20. ↑ https://www.biospace.com/article/abbvie-announces-commencement-of-exchange-offers-and-consent-solicitations-for-allergan-notes/?s=79
21. ↑ "AbbVie, Maker of World's No. 1 Drug, Bets Synthetic Biology Startup Can Raise the Bar". February 10, 2016. https://www.forbes.com/sites/luketimmerman/2016/02/10/abbvie-maker-of-worlds-no-1-drug-bets-synthetic-biology-startup-can-keep-it-going/#26b6354972df. Retrieved February 10, 2016.
22. ↑ "AbbVie, University of Chicago Launch Cancer Research Alliance". GEN. http://www.genengnews.com/gen-news-highlights/abbvie-university-of-chicago-launch-cancer-research-alliance/81252632/.
23. ↑ "AbbVie to Co-Develop argenx's Cancer Immunotherapy ARGX-115 - GEN News Highlights - GEN". GEN. http://www.genengnews.com/gen-news-highlights/abbvie-to-co-develop-argen-x-s-cancer-immunotherapy-argx-115/81252638/.
24. ↑ "AbbVie to Co-Commercialize CytomX's Probody Drug Conjugates". GEN. http://www.genengnews.com/gen-news-highlights/abbvie-to-co-commercialize-cytomx-s-probody-drug-conjugates/81252642/.
25. ↑ 25.0 25.1 Walker, Joseph (1 January 2016). "Patients Struggle With High Drug Prices". Wall Street Journal. https://www.wsj.com/articles/patients-struggle-with-high-drug-prices-1451557981. Retrieved 1 January 2016.
26. ↑ "NHS England taken to court over 'largest ever medicines procurement'". Health Service Journal. 6 November 2018. https://www.hsj.co.uk/service-design/nhs-england-taken-to-court-over-largest-ever-medicines-procurement/7023733.article. Retrieved 8 December 2018.
27. ↑ Talha Burki.UK court dismisses AbbVie's legal challenge against the NHS The Lancet. Volume 393, ISSUE 10169, P307-308, January 26, 2019
28. ↑ Carroll, John (October 25, 2019). "AbbVie doubles down on cystic fibrosis R&D, adding a new drug to the pipeline as Vertex seals its domination of the field with Trikafta OK". https://endpts.com/abbvie-doubles-down-on-cystic-fibrosis-rd-adding-a-new-drug-to-the-pipeline-as-vertex-seals-its-domination-of-the-field-with-trikafta-ok/.

## External links

* Business data for AbbVie:

* Google Finance
* Yahoo! Finance
* Reuters
* SEC filings

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