QIAGEN Silicon Valley

Short description: Biotechnology software company

QIAGEN Silicon ValleyIndustry| software

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Founded| 2003
Headquarters| Redwood City, California
Website| www.qiagen.com/us/

QIAGEN Silicon Valley (formerly Ingenuity Systems) is a company based in Redwood City, California, USA, that develops software to analyze complex biological systems. QIAGEN Silicon Valley's first product, IPA, was introduced in 2003, and is used to help researchers analyze omics data and model biological systems. The software has been cited in thousands of scientific molecular biology publications and is one of several tools for systems biology researchers and bioinformaticians in drug discovery and institutional research.

## Contents

* 1 Technology
* 2 Products and services
* 3 Timeline
* 4 See also
* 5 References
* 6 External links

## Technology

All QIAGEN Silicon Valley products use the Ingenuity Knowledge Base, which contains biological and chemical interactions and functional annotations created from millions of individually modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases.[citation needed] Each relationship originates from reported experimental facts from primary literature sources, including peer-reviewed journal articles[citation needed] and textbooks[citation needed]. The knowledge acquisition and extraction process is protected by multiple US Patents.[1]

## Products and services

IPA is broadly adopted[according to whom?] in the life science community and has been cited in thousands of peer-reviewed journal articles.[2] IPA can be used with or without data. IPA helps researchers analyze data derived from expression and SNP microarrays, proteomics experiments, and small-scale experiments that generate gene lists, in order to gain insight into molecular and chemical interactions, cellular phenotypes, and disease processes within a system. IPA also lets researchers search for information on genes, proteins, chemicals, drugs, and reagents. Resulting information can be used to build biological models, design experiments, or get up to speed in an area of research.[3]

Ingenuity offers search and visualization tools for science related e-commerce websites. Ingenuity has two prominent partnerships: Sigma-Aldrich leverages Ingenuity technology in their Your Favorite Gene application, and BD Biosciences leverages Ingenuity technology in their BD Cell Pathways[4] application.

## Timeline

2003 - Ingenuity first offers Ingenuity Knowledge Base[5]
2004 - Stanford University licenses IPA[6]
2004 - Independent analysis finds significant ROI for pharmaceutical companies using IPA[7]
2005 - US Food and Drug Administration adopts IPA to review pharmacogenomics submissions[8]
2006 - Ingenuity enters into partnerships with Asuragen, Spotfire, Agilent, Genedata, and Inforsense[9]
2007 - Ingenuity introduces toxicology and biomarker capabilities within IPA 5.0[10]
2007 - IPA 5.0 wins Best in Show - Best New Product at Bio-IT World[11]
2007 - Ingenuity and FDA enter three year collaboration to enhance regulatory review process[12]
2008 - IPA's newest feature, Path Designer, wins Best New Product at Molecular Medicine[13]
2009 - Sigma Aldrich launches Your Favorite Gene - Powered by Ingenuity[14]
2009 - BD Biosciences launches BD Cell Pathways, powered by Ingenuity[15]
2011 - Ingenuity announces early access to Ingenuity iReport[16]
2012 - Ingenuity announces commercial availability of Ingenuity iReport and Ingenuity Variant Analysis[17][18]
2013 - Ingenuity announces collaborations with both Laboratory Corporation and Quest Diagnostics to develop a solution for scoring genetic variation for next generation sequencing data (NGS) and is purchased by QIAGEN in May of the same year

## See also

* Systems biology
* Bioinformatics
* Computational genomics
* Computational biology
* Microarray analysis
* DNA microarray
* Pathway analysis

## References

1. ↑ "United States Patent: 7943742". US Patent Office. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=5&f=G&l=50&co1=AND&d=PTXT&s1="Ingenuity+Systems"&OS="Ingenuity+Systems"&RS="Ingenuity+Systems".
2. ↑ "Bibliography". Ingenuity Systems. http://www.ingenuity.com/library/pdf/bibliography.pdf.
3. ↑ "Ingenuity IPA Software - Pathway Analysis, miRNA, NGS, RNA-Seq, Microarrays, Gene Expression, Biomarkers". Ingenuity Systems. http://www.ingenuity.com/products/pathways_analysis.html.
4. ↑ BD Cell Pathways
5. ↑ "Ingenuity Systems Announces Immediate Availability Of The Ingenuity Pathways Knowledge Base" (Press release). Ingenuity Systems. May 27, 2003. Retrieved April 7, 2012.
6. ↑ "Stanford University Licenses IPA, Collaborates on Systems Biology Solutions" (Press release). Ingenuity Systems. November 3, 2003. Retrieved April 7, 2012.
7. ↑ "The Return on Investment for Ingenuity Pathways Analysis within the Pharmaceutical Value Chain", Zimmerman, Reeve, and Golden, Life Science Insights, an IDC company, July 2004
8. ↑ "The U.S. Food and Drug Administration to use IPA in review of Pharmacogenomics Submissions" (Press release). Ingenuity Systems. June 21, 2005. Retrieved April 7, 2012.
9. ↑ "Press release archive". Ingenuity Systems. http://www.ingenuity.com/news/prarchive.html.
10. ↑ "Ingenuity Systems releases IPA™ 5.0 software, offering new biomarker and molecular toxicology capabilities" (PDF) (Press release). Ingenuity Systems. April 17, 2007. Retrieved April 7, 2012.
11. ↑ "Best of Show: Life Science Software & Informatics". Bio-IT World. June 13, 2007. http://www.bio-itworld.com/issues/2007/june/bos-life-science-software-informatics/.
12. ↑ "Ingenuity Systems and FDA Enter 3-Year, $6 Million Collaboration to Enhance Regulatory Review Process" (Press release). Ingenuity Systems. November 27, 2007. Retrieved April 7, 2012.
13. ↑ "Best of Show Award Winners Named at the Fifteenth International Molecular Medicine Tri-Conference" (Press release). Cambridge Healthtech Institute. April 3, 2008. Retrieved April 7, 2012.
14. ↑ "Sigma-Aldrich Launches Your Favorite Gene Powered by Ingenuity, Sigma-Aldrich Co" (Press release). Sigma-Aldrich Co., Inc. January 27, 2009. Retrieved April 7, 2012.
15. ↑ "Ingenuity's Technology Powers BD Cell Pathways Tool on New BD Biosciences Website" (Press release). Ingenuity Systems. August 10, 2009. Retrieved April 7, 2012.
16. ↑ "Ingenuity Systems Unveils Early Access to Revolutionary New iReport" (Press release). Ingenuity Systems. September 29, 2011. Retrieved April 7, 2012.
17. ↑ "New Products: Randox Laboratories' Beta-Lactams Array; Ingenuity Systems' iReport". BioArray News (GenomeWeb). January 24, 2012. http://www.genomeweb.com/arrays/new-products-randox-laboratories-beta-lactams-array-ingenuity-systems-ireport.
18. ↑ "Ingenuity Preps New NGS Variant Analysis Tool, Signs Translational Oncology Group as Beta Tester". BioInform (GenomeWeb). January 13, 2012. http://www.genomeweb.com/informatics/ingenuity-preps-new-ngs-variant-analysis-tool-signs-translational-oncology-group.

## External links

* ingenuity.com

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