Alcoholic hepatitis

Micrograph showing a Mallory body, a histopathologic finding associated with alcoholic hepatitis. H&E stain.
Specialty| Gastroenterology
Complications| Cirrhosis, Kidney failure, Confusion, drowsiness and slurred speech (hepatic encephalopathy), Ascites, Enlarged veins (varices).[1]
Risk factors| Your sex, Obesity, Genetic factors, Race and ethnicity, Binge drinking.[1]

Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol.[2] Patients typically have a history of at least 10 years of heavy alcohol intake, typically 8-10 drinks per day.[3] It is usually found in association with fatty liver, an early stage of alcoholic liver disease, and may contribute to the progression of fibrosis, leading to cirrhosis. Symptoms may present acutely after a large amount of alcoholic intake in a short time period, or after years of excess alcohol intake. Signs and symptoms of alcoholic hepatitis include jaundice (yellowing of the skin and eyes), ascites (fluid accumulation in the abdominal cavity), fatigue and hepatic encephalopathy (brain dysfunction due to liver failure).[3] Mild cases are self-limiting, but severe cases have a high risk of death. Severe cases may be treated with glucocorticoids. The condition often comes on suddenly and may progress in severity very rapidly.

## Contents

* 1 Signs and symptoms
* 2 Pathophysiology
* 3 Epidemiology
* 4 Diagnosis
* 5 Management
* 6 Prognosis
* 7 See also
* 8 References
* 9 External links

## Signs and symptoms

Alcoholic hepatitis is characterized by a number of symptoms, which may include feeling unwell, enlargement of the liver, development of fluid in the abdomen (ascites), and modest elevation of liver enzyme levels (as determined by liver function tests).[4] It may also present with Hepatic encephalopathy (brain dysfunction due to liver failure) causing symptoms such as confusion, decreased levels of consciousness, or asterixis,[5] (a characteristic flapping movement when the wrist is extended indicative of hepatic encephalopathy). Severe cases are characterized by profound jaundice, obtundation (ranging from drowsiness to unconsciousness), and progressive critical illness; the mortality rate is 50% within 30 days of onset despite best care.[3]

Alcoholic hepatitis is distinct from cirrhosis caused by long-term alcohol consumption. Alcoholic hepatitis can occur in patients with chronic alcoholic liver disease and alcoholic cirrhosis. Alcoholic hepatitis by itself does not lead to cirrhosis, but cirrhosis is more common in patients with long term alcohol consumption.[6] Some alcoholics develop acute hepatitis as an inflammatory reaction to the cells affected by fatty change.[6] This is not directly related to the dose of alcohol. Some people seem more prone to this reaction than others. This inflammatory reaction to the fatty change is called alcoholic steatohepatitis and the inflammation probably predisposes to liver fibrosis by activating hepatic stellate cells to produce collagen.[6]

Depiction of a liver failure patient

## Pathophysiology

The pathological mechanisms in alcoholic hepatitis are incompletely understood but a combination of direct hepatocyte damage by alcohol and its metabolites in addition to increased intestinal permeability are thought to play a role.[7] Heavy alcohol consumption increases intestinal permeability by causing direct damage to enterocytes (intestinal absorptive cells) and causing disruptions of tight junctions that form a barrier between the enterocytes.[7] This leads to increased intestinal permeability which then leads to pathogenic gut bacteria (such as enterococcus faecalis) or immunogenic fungi entering the portal circulation, and travelling to the liver where they cause hepatocyte damage.[7] In the case of enterococcus faecalis, the bacterium can release an exotoxin which is directly damaging to liver cells.[7] Chronic alcohol consumption may alter the gut microbiome and promote the production of these pathogenic bacteria.[7] Many of these pathogenic bacteria also contain Pathogen Associated Molecular Patterns (PAMPs), extracellular motifs that are recognized by the immune system as foreign material, which may lead to an exaggerated inflammatory response in the liver which further leads to hepatocyte damage.[7]

Alcohol is also directly damaging to liver cells. Alcohol is metabolized to acetaldehyde in the liver via the enzymes CYP2E1 and aldehyde dehydrogenase.[7] Acetaldehyde forms reactive oxygen species in the liver as well as acting as a DNA adduct (binding to DNA) leading to direct hepatocyte damage.[7] This manifests as lipid peroxidation, mitochondrial damage, and glutathione (an endogenous antioxidant) depletion.[7] Damaged hepatocytes release Danger associated molecular patterns (DAMPs) which are molecules that lead to further activation of the immune system's inflammatory response and further hepatocyte damage.[7]

The chronic inflammation seen in alcoholic hepatitis leads to a distinctive fibrotic response, with fibrogenic cell type activation. This occurs via an increased extracellular matrix deposition around hepatocytes and sinusoidal cells which causes a peri-cellular fibrosis known as "chickenwire fibrosis".[7] This peri-cellular chickenwire fibrosis leads to portal hypertension or an elevated blood pressure in the portal veins that drain blood from the intestines to the liver.[7] This causes many of the sequelae of chronic liver disease including esophageal varices (with associated variceal bleeding), ascites and splenomegaly.

The chronic inflammation seen in alcoholic hepatitis also leads to impaired hepatocyte differentiation, impairments in hepatocyte regeneration and hepatocyte de-differentiation into cholangiocyte type cells.[7] This leads to defects in the liver's many functions including impairments in bilirubin transport, clotting factor synthesis, glucose metabolism and immune dysfunction.[7] This impaired compensatory liver regenerative response further leads to a ductular reaction; a type of abnormal liver cell architecture.[7]

Some signs and pathological changes in liver histology include:

* Mallory's hyaline body – a condition where pre-keratin filaments accumulate in hepatocytes. This sign is not limited to alcoholic liver disease, but is often characteristic.[6]
* Ballooning degeneration – hepatocytes in the setting of alcoholic change often swell up with excess fat, water and protein; normally these proteins are exported into the bloodstream. Accompanied with ballooning, there is necrotic damage. The swelling is capable of blocking nearby biliary ducts, leading to diffuse cholestasis.[6]
* Inflammation – neutrophilic invasion is triggered by the necrotic changes and presence of cellular debris within the lobules. Ordinarily the amount of debris is removed by Kupffer cells, although in the setting of inflammation they become overloaded, allowing other white cells to spill into the parenchyma. These cells are particularly attracted to hepatocytes with Mallory bodies.[6]

If chronic liver disease is also present:

* Fibrosis
* Cirrhosis – a progressive and permanent type of fibrotic degeneration of liver tissue.

Pathogenesis alcoholic liver injury

File:Alcohol related liver disease.webm

## Epidemiology

* Alcoholic hepatitis occurs in approximately 1/3 of chronic alcohol drinkers.[8]
* 10-20% of patients with alcoholic hepatitis progress to alcoholic liver cirrhosis every year.[9]
* Patients with liver cirrhosis develop liver cancer at a rate of 1.5% per year.[10]
* In total, 70% of those with alcoholic hepatitis will go on to develop alcoholic liver cirrhosis in their lifetimes.[9]
* Infection risk is elevated in patients with alcoholic hepatitis (12-26%). It increases even higher with use of corticosteroids (50%)[11] when compared with the general population.
* Untreated alcoholic hepatitis mortality in one month of presentation may be as high as 40-50%.[4]

## Diagnosis

The diagnosis is made in a patient with history of significant alcohol intake who develops worsening liver function tests, including elevated bilirubin (typically greater than 3.0) and aminotransferases, and onset of jaundice within the last 8 weeks.[3] The ratio of aspartate aminotransferase to alanine aminotransferase is usually 2 or more.[12] In most cases, the liver enzymes do not exceed 500. A liver biopsy is not required for the diagnosis, however it can help confirm alcoholic hepatitis as the cause of the hepatitis if the diagnosis is unclear.[3][13]

## Management

Clinical practice guidelines have recommended corticosteroids.[14] People should be risk stratified using a MELD Score or Child-Pugh score. These scores are used to evaluate the severity of the liver disease based on several lab values. The greater the score, the more severe the disease.

* Abstinence: Stopping further alcohol consumption is the number one factor for recovery in patients with alcoholic hepatitis.[15]
* Nutrition Supplementation: Protein and calorie deficiencies are seen frequently in patients with alcoholic hepatitis, and it negatively affects their outcomes. Improved nutrition has been shown to improve liver function and reduce incidences encephalopathy and infections.[4]
* Corticosteroids: These guidelines suggest that patients with a modified Maddrey's discriminant function score > 32 or hepatic encephalopathy should be considered for treatment with prednisolone 40 mg daily for four weeks followed by a taper.[14] Models such as the Lille Model can be used to monitor for improvement or to consider alternative treatment.
* Pentoxifylline: Systematic reviews comparing the treatment of pentoxifylline with corticosteroids show there is no benefit to treatment with pentoxifylline[4] Potential for combined therapy: A large prospective study of over 1000 patients investigated whether prednisolone and pentoxifylline produced benefits when used alone or in combination.[16] Pentoxifylline did not improve survival alone or in combination. Prednisolone gave a small reduction in mortality at 28 days but this did not reach significance, and there were no improvements in outcomes at 90 days or 1 year.[4]
* Intravenous N-acetylcysteine: When used in conjunction with corticosteroids, improves survival at 28 days by decreasing rates of infection and hepatorenal syndrome.[4]
* Liver Transplantation: Early liver transplantation is ideal and helps to save lives.[17] However, most transplant providers in the United States require a period of alcohol abstinence (typically six months) prior to transplant, but the ethics and science behind this are controversial.[17]

## Prognosis

Females are more susceptible to alcohol-associated liver injury and are therefore at higher risk of alcohol-associated hepatitis.[7] Certain genetic variations in the PNPLA3-encoding gene, which codes for an enzyme involved in triglyceride metabolism in adipose tissue are thought to influence disease severity.[7] Other factors in alcoholic hepatitis associated with a poor prognosis include concomitant hepatic encephalopathy and acute kidney injury.[7]

## See also

* AST/ALT ratio
* Lille Model
* Steatohepatitis

## References

1. ↑ 1.0 1.1 "Alcoholic hepatitis". Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/alcoholic-hepatitis/symptoms-causes/syc-20351388.
2. ↑ "Alcoholic liver disease: MedlinePlus Medical Encyclopedia". https://medlineplus.gov/ency/article/000281.htm.
3. ↑ 3.0 3.1 3.2 3.3 3.4 Im, Gene Y. (February 2019). "Acute Alcoholic Hepatitis" (in en). Clinics in Liver Disease 23 (1): 81–98. doi:10.1016/j.cld.2018.09.005. PMID 30454835.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Singal, Ashwani K.; Kodali, Sudha; Vucovich, Lee A.; Darley-Usmar, Victor; Schiano, Thomas D. (July 2016). "Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review" (in en). Alcoholism: Clinical and Experimental Research 40 (7): 1390–1402. doi:10.1111/acer.13108. PMID 27254289.
5. ↑ Amodio, Piero (June 2018). "Hepatic encephalopathy: Diagnosis and management" (in en). Liver International 38 (6): 966–975. doi:10.1111/liv.13752. PMID 29624860.
6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 Bataller, Ramon; Arab, Juan Pablo; Shah, Vijay H. (29 December 2022). "Alcohol-Associated Hepatitis". New England Journal of Medicine 387 (26): 2436–2448. doi:10.1056/NEJMra2207599. PMID 36577100.
8. ↑ Barrio, E.; Tomé, S.; Rodríguez, I.; Gude, F.; Sánchez-Leira, J.; Pérez-Becerra, E.; González-Quintela, A. (January 2004). "Liver Disease in Heavy Drinkers With and Without Alcohol Withdrawal Syndrome" (in en). Alcoholism: Clinical & Experimental Research 28 (1): 131–136. doi:10.1097/01.ALC.0000106301.39746.EB. ISSN 0145-6008. PMID 14745311.
9. ↑ 9.0 9.1 Fleming, Kate M.; Aithal, Guruprasad P.; Card, Tim R.; West, Joe (January 2012). "All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study: Cirrhosis mortality" (in en). Liver International 32 (1): 79–84. doi:10.1111/j.1478-3231.2011.02517.x. PMID 21745279. http://eprints.nottingham.ac.uk/45119/8/Mortality_Feb2011 LiverInt.pdf. Retrieved 2020-03-15.
10. ↑ Schwartz, Jonathan M.; Reinus, John F. (November 2012). "Prevalence and Natural History of Alcoholic Liver Disease" (in en). Clinics in Liver Disease 16 (4): 659–666. doi:10.1016/j.cld.2012.08.001. PMID 23101975.
11. ↑ Louvet, Alexandre; Wartel, Faustine; Castel, Hélène; Dharancy, Sébastien; Hollebecque, Antoine; Canva–Delcambre, Valérie; Deltenre, Pierre; Mathurin, Philippe (August 2009). "Infection in Patients With Severe Alcoholic Hepatitis Treated With Steroids: Early Response to Therapy Is the Key Factor". Gastroenterology 137 (2): 541–548. doi:10.1053/j.gastro.2009.04.062. ISSN 0016-5085. PMID 19445945.
12. ↑ "The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease". Am. J. Gastroenterol. 94 (4): 1018–22. 1999. doi:10.1111/j.1572-0241.1999.01006.x. PMID 10201476.
13. ↑ Keating, Michelle; Lardo, Olivia; Hansell, Maggie (1 April 2022). "Alcoholic Hepatitis: Diagnosis and Management". American Family Physician 105 (4): 412–420. PMID 35426628.
14. ↑ 14.0 14.1 "Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology". Am. J. Gastroenterol. 93 (11): 2022–36. 1998. doi:10.1111/j.1572-0241.1998.00587.x. PMID 9820369.
15. ↑ Louvet, Alexandre; Labreuche, Julien; Artru, Florent; Bouthors, Alexis; Rolland, Benjamin; Saffers, Pierre; Lollivier, Julien; Lemaître, Elise et al. (26 September 2017). "Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: A prospective study". Hepatology 66 (5): 1464–1473. doi:10.1002/hep.29240. ISSN 0270-9139. PMID 28459138.
16. ↑ "Prednisolone or pentoxifylline for alcoholic hepatitis". N. Engl. J. Med. 372 (17): 1619–28. 2015. doi:10.1056/NEJMoa1412278. PMID 25901427.
17. ↑ 17.0 17.1 Lee, Brian P.; Terrault, Norah A. (April 2018). "Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus" (in en). Current Opinion in Organ Transplantation 23 (2): 229–236. doi:10.1097/MOT.0000000000000507. ISSN 1087-2418. PMID 29389821. PMC 6423506. http://insights.ovid.com/crossref?an=00075200-201804000-00016.

## External links

Classification|

* ICD-10: K70.1
* ICD-9-CM: 571.1
* MeSH: D006519

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External resources|

* MedlinePlus: 000281

* v
* t
* e

Diseases of the digestive system (primarily K20–K93, 530–579)

Upper GI tract|

| Esophagus|

* Esophagitis
* Candidal
* Eosinophilic
* Herpetiform
* Rupture
* Boerhaave syndrome
* Mallory–Weiss syndrome
* UES
* Zenker's diverticulum
* LES
* Barrett's esophagus
* Esophageal motility disorder
* Nutcracker esophagus
* Achalasia
* Diffuse esophageal spasm
* Gastroesophageal reflux disease (GERD)
* Laryngopharyngeal reflux (LPR)
* Esophageal stricture
* Megaesophagus

|

Stomach|

* Gastritis
* Atrophic
* Ménétrier's disease
* Gastroenteritis
* Peptic (gastric) ulcer
* Cushing ulcer
* Dieulafoy's lesion
* Dyspepsia
* Pyloric stenosis
* Achlorhydria
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* Portal hypertensive gastropathy
* Gastric antral vascular ectasia
* Gastric dumping syndrome
* Gastric volvulus
* Buried bumper syndrome

Lower GI tract:
Intestinal/
Enteropathy|

| Small intestine
(Duodenum/Jejunum/Ileum)|

* Enteritis
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|

Large intestine
(Appendix/Colon)|

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Large and/or small|

* Enterocolitis
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Rectum|

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GI bleeding/BIS|

* Upper
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Accessory|

| Liver|

* Hepatitis
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* Cirrhosis
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* Pyogenic
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* Peliosis hepatis
* Metabolic disorders
* Wilson's disease
* Hemochromatosis

|

Gallbladder|

* Cholecystitis
* Gallstones/Cholecystolithiasis
* Cholesterolosis
* Adenomyomatosis
* Postcholecystectomy syndrome
* Porcelain gallbladder

Bile duct/
Other biliary tree|

* Cholangitis
* Primary sclerosing cholangitis
* Secondary sclerosing cholangitis
* Ascending
* Cholestasis/Mirizzi's syndrome
* Biliary fistula
* Haemobilia
* Gallstones/Cholelithiasis

* Common bile duct
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* Biliary dyskinesia
* Sphincter of Oddi dysfunction

Pancreatic|

* Pancreatitis
* Acute
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* Hereditary
* Pancreatic abscess
* Pancreatic pseudocyst
* Exocrine pancreatic insufficiency
* Pancreatic fistula

Abdominopelvic|

| Hernia|

* Diaphragmatic
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* Inguinal
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* Femoral
* Obturator
* Spigelian

* Lumbar
* Petit's
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* Undefined location
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* Richter's

|

Peritoneal|

* Peritonitis
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* Hemoperitoneum
* Pneumoperitoneum

* v
* t
* e

Alcohol and health

Alcohol use|

| Alcohol-related crimes|

* Drunk drivers
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|

Alcoholism|

Note: see Template:Psychoactive substance use for diagnoses, and Category:Psychiatric instruments: alcohol abuse for treatment evaluation instruments.

* Alcohol and Native Americans
* Alcoholism in adolescence
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* Collaborative Study on the Genetics of Alcoholism
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Chemistry|

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* Effects of alcohol consumption
* short-term
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Interactions|

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Social issues|

* Alcohol advertising
* on college campuses
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* Binge drinking
* Epidemiology
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* Drinking in public
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* Drunkorexia
* Dry drunk
* French paradox
* Hair of the dog
* Nightcap
* Passive drinking
* Binge drinking devices
* Beer bong
* Yard of ale
* Routes of administration
* Alcohol enema
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* Sconcing
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* Related issues
* Balconing
* Suicide

History|

* Dionysian Mysteries
* Dipsomania
* Gin Craze
* List of deaths through alcohol
* Rum ration
* Speakeasy

General|

* Beer day
* Drinking culture
* Apéritif and digestif
* Hangover remedies
* Health effects of wine
* Wine and food matching
* Long-distance race involving alcohol
* List of countries by alcohol consumption per capita
* Alcohol consumption by youth in the United States
* Nip joint

Alcohol control|

| Alcohol law|

* Administrative license suspension (ALS)
* Alcohol packaging warning messages
* Drunk driving law by country
* DWI court
* Field sobriety testing
* Hip flask defence
* Ignition interlock device
* Legal drinking age
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* Underage drinking in America
* List of alcohol laws of the United States

|

Alcohol prohibition|

* List of countries with alcohol prohibition
* Neo-prohibitionism
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Sobriety|

* Alcohol detoxification
* Alcohol-free zone
* United States open-container laws
* Designated driver
* Alcohol rehabilitation
* Drunk tank
* Managed alcohol program
* Non-alcoholic drink
* List of non-alcoholic cocktails
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* Non-alcoholic spritzer
* Non-alcoholic malt drinks
* Teetotalism
* Temperance bar
* Twelve-step groups
* Al-Anon/Alateen
* Alcoholics Anonymous (AA):
* Adult Children of Alcoholics (ACA)

Alcohol limitation|

* 0-0-1-3
* Alcohol education
* Alcohol server training
* FRAMES
* Dry January
* Foundation for Advancing Alcohol Responsibility
* Campaigns
* Get Your Sexy Back
* Low-alcohol drinks
* Fermented tea
* Low-alcohol beer
* Low-alcoholic malt drinks
* Small beer
* Measurement
* Alcoholic spirits measure
* Standard drink
* Recommended maximum intake of alcoholic beverages

Addiction medicine|

* Disulfiram-like drugs: disulfiram, calcium carbimide, cyanamide. [[Chemistry:Sulfonic Sulfonic acid]]s: Acamprosate

Religion and alcohol|

* Christian views on alcohol
* alcohol in the Bible
* Islam and alcohol

History|

* Bratt System

Related|

* Index of alcohol-related articles
* Austrian syndrome
* Ban on caffeinated alcoholic beverages
* Brief intervention
* Gateway drug effect
* Mood disorder
* Non-alcoholic fatty liver disease
* Self-medication
* Spins
* Sober companion
* Sober living houses
* Sobering center
* Town drunk

* Category

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