Atypical small acinar proliferation

Other names| ASAP

In urologic pathology, atypical small acinar proliferation, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.

ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty,[1] and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test.

## Contents

* 1 Association with adenocarcinoma
* 2 Management
* 3 See also
* 4 References
* 5 External links

## Association with adenocarcinoma

On a subsequent biopsy, given the diagnosis of ASAP, the chance of finding prostate adenocarcinoma is approximately 40%; this is higher than if there is high-grade prostatic intraepithelial neoplasia (HGPIN).[2]

## Management

ASAP is considered an indication for re-biopsy;[3] in one survey of urologists[4] 98% of respondents considered it a sufficient reason to re-biopsy.

## See also

* Sensitivity

## References

1. ↑ "Atypical small acinar proliferation: biopsy artefact or distinct pathological entity". BJU International 99 (4): 780–5. January 2007. doi:10.1111/j.1464-410X.2006.06703.x. PMID 17378841. http://www3.interscience.wiley.com/journal/118508438/abstract.
2. ↑ "Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy". Clinics 63 (3): 339–42. June 2008. doi:10.1590/S1807-59322008000300009. PMID 18568243.
3. ↑ "Atypical small acinar proliferation in the prostate: clinical significance in 2006". Arch. Pathol. Lab. Med. 130 (7): 952–7. July 2006. doi:10.5858/2006-130-952-ASAPIT. PMID 16831049. https://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2006)130[952:ASAPIT]2.0.CO;2.
4. ↑ "Prostate needle biopsy reporting: how are the surgical members of the Society of Urologic Oncology using pathology reports to guide treatment of prostate cancer patients?". Am. J. Surg. Pathol. 28 (7): 946–52. July 2004. doi:10.1097/00000478-200407000-00016. PMID 15223967.

## External links

Classification|

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External resources|

* eMedicine: med/3056

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