Azzopardi phenomenon

The Azzopardi phenomenon, or Azzopardi effect, is the presence of DNA in necrotic venules.[1] It can occur in small cell carcinomas and in some high-grade malignant neoplasms.[1][2] The effect is well known in diagnostic surgical pathology.[3] The phenomenon is named after the pathologist, John G. Azzopardi.[4][5][6] Azzopardi was able to correctly characterize the effect as due to DNA; it had been thought previously but incorrectly to be calcium.[4] Necrosis results in the release of cellular DNA, which adheres in patches to the walls of blood vessels, showing as intensely basophilic material on hematoxylin-eosin stain.[1]

The Azzopardi phenomenon is distinguished from the similar basophilic hematoxylin body. [citation needed]

## References

1. ↑ 1.0 1.1 1.2 "The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology". Int. J. Surg. Pathol. 22 (1): 12–32. 2014. doi:10.1177/1066896913517939. PMID 24406626.
2. ↑ "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682–3. 2007. doi:10.5858/2007-131-682-BLWAP. PMID 17488151. https://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2007)131[682:BLWAP]2.0.CO;2.
3. ↑ "The Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (4): 518. 2007. doi:10.5858/2007-131-518-TAP. PMID 17425376. https://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2007)131[518:TAP]2.0.CO;2.
4. ↑ 4.0 4.1 "The Azzopardi phenomenon". Arch. Pathol. Lab. Med. 127 (9): 1231. 2003. doi:10.5858/2003-127-1231-TAP. PMID 12951999. https://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2003)127<1231:TAP>2.0.CO;2.
5. ↑ "Merkel cell carcinoma and Azzopardi phenomenon". Am J Dermatopathol 29 (3): 314–5. 2007. doi:10.1097/DAD.0b013e318033901b. PMID 17519638.
6. ↑ "Oat-cell carcinoma of the bronchus". J Pathol Bacteriol 78 (2): 513–9. 1959. doi:10.1002/path.1700780218. PMID 13795444.

## External links

* Warnock ML, McCowin MJ in Practical Pathology of Chest Disease--Case Studies
* Azzopardi phenomenon in a metastatic small cell carcinoma of the lung

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