Bleb

Blue rubber bleb nevus syndrome

In medicine, a bleb is a blister-like protrusion[1][2] (often hemispherical) filled with serous fluid. Blebs can form in a number of tissues by different pathologies, including frostbite and can "appear and disappear within a short time interval".[3][4]

In pathology pulmonary blebs are small subpleural thin-walled air-containing spaces, not larger than 1-2 cm in diameter. Their walls are less than 1 mm thick. If they rupture, they allow air to escape into pleural space, resulting in a spontaneous pneumothorax.

In ophthalmology, blebs may be formed intentionally in the treatment of glaucoma. In such treatments, functional blebs facilitate the circulation of aqueous humor, the blockage of which will lead to increase in eye pressure. Use of collagen matrix wound modulation device such as ologen during glaucoma surgery is known to produce vascular and functional blebs, which are positively correlated with treatment success rate. [5][6][7][8]

In the lungs, a bleb is a collection of air within the layers of the visceral pleura.

In breasts a bleb is a milk blister (also known as blocked nipple pore, nipple blister, or “milk under the skin”).[9]

## External links

* Medical definition of bleb on MedicineNet.com
* Moorfields Bleb Grading System

## References

1. ↑ Ponuwei, Godwin A.; Dash, Phil R. (2016-12-01). "Bleb Formation in Human Fibrosarcoma HT1080 Cancer Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 (PLD2)" (in en). Achievements in the Life Sciences 10 (2): 125–135. doi:10.1016/j.als.2016.11.001. ISSN 2078-1520.
2. ↑ G. Charras, E. Paluch Blebs lead the way: how to migrate without lamellipodia Nat. Rev. Mol. Cell Biol., 9 (2008), pp. 730-736
3. ↑ Ponuwei, Godwin A.; Dash, Phil R. (2016-12-01). "Bleb Formation in Human Fibrosarcoma HT1080 Cancer Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 (PLD2)" (in en). Achievements in the Life Sciences 10 (2): 125–135. doi:10.1016/j.als.2016.11.001. ISSN 2078-1520.
4. ↑ G. Charras, E. Paluch Blebs lead the way: how to migrate without lamellipodia Nat. Rev. Mol. Cell Biol., 9 (2008), pp. 730-736
5. ↑ Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years". J Ophthalmol 2015: 637537. doi:10.1155/2015/637537. PMID 26078875.
6. ↑ Min JK, Kee CW, Sohn SW, Lee HJ, Woo JM, Yim JH (2013). "Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma 22 (6): 456–62. doi:10.1097/ijg.0b013e31826ab6b1. PMID 23263152.
7. ↑ Boey PY, Narayanaswamy A, Zheng C, Perera SA, Htoon HM, Tun TA, Seah SK, Wong TT, Aung T (2011). "Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants". Br J Ophthalmol 95 (3): 340–4. doi:10.1136/bjo.2009.177758. PMID 20693559.
8. ↑ Aptel F, Dumas S, Denis P (2009). "Ultrasound biomicroscopy and optical coherence tomography imaging of filtering blebs after deep sclerectomy with new collagen implant". Eur J Ophthalmol 19 (2): 223–30. doi:10.1177/112067210901900208. PMID 19253238.
9. ↑ White spot on the nipple

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