Brown tumor

Short description: Massive bone lesion due to excess osteoclast activity

Brown tumor

Brown tumours of the hands in a patient with hyperparathyroidism.

The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. They are a form of osteitis fibrosa cystica. It is not a neoplasm, but rather simply a mass. It most commonly affects the maxilla and mandible, though any bone may be affected.[1] Brown tumours are radiolucent on x-ray.

## Contents

* 1 Pathology
* 2 Diagnosis
* 3 Treatment
* 4 Epidemiology
* 5 See also
* 6 References
* 7 External links

## Pathology

Micrograph of a brown tumor (left of image). H&E stain.

Brown tumours consist of fibrous tissue, woven bone and supporting vasculature, but no matrix. The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone deposition followed by additional resorption can expand beyond the usual shape of the bone, involving the periosteum thus causing bone pain. The characteristic brown coloration results from hemosiderin deposition into the osteolytic cysts. Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen in giant cell tumors of the bone.[2][3]

Brown tumors may be rarely associated with ectopic parathyroid adenomas[4] or end stage renal osteodystrophy.[5]

## Diagnosis

Histologically, it is impossible to distinguish a Brown tumor of hyperparathyroidism from other giant cell lesions of bone. Rarely a focal collection of osteoclasts (brown tumor) may occur in relation to periosteum and be indistinguishable from a peripheral giant cell granuloma (giant cell epulis). The possibility of hyperparathyroidism should be considered in patients with recurrent or multiple giant cell epulides.[6]

Radiographically, brown tumor may show no detectable changes or a generalized osteoporosis. Partial loss of lamina dura around the teeth may occur but is not a constant feature. Focal Lesions (Brown Tumor) present as sharply defined, round or oval radiolucent areas which may appear multilocular. Such lesions occur more frequently in mandible than maxilla [6]

## Treatment

Treatment of hyperparathyroidism is required. Parathyroidectomy usually leads to spontaneous healing of Brown tumors in primary cases.[7] Calcitriol (Rocaltrol) and cinacalcet (a calcimimetic) are used as pharmacologic treatments.[8][9]

## Epidemiology

Age and gender have an effect on the incidence of these lesions; they are more prevalent in women than men (though still common in both genders), and they appear more frequently with age. Due to the standard of medical care and screening in developed countries, it is increasingly rare for primary hyperparathyroidism to present with accompanying bone disease. This is not the case in less developed nations, however, and the two conditions are more often seen together.[10]

## See also

* Osteitis fibrosa cystica

## References

1. ↑ "Brown tumors mimicking bone metastases". Journal of the National Medical Association 98 (6): 950–3. June 2006. PMID 16775919.
2. ↑ "Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation". Journal of Computer Assisted Tomography 15 (6): 1024–7. 1991. doi:10.1097/00004728-199111000-00023. PMID 1939753.
3. ↑ "Giant cell tumor of the temporal bone with intratumoral hemorrhage". Journal of Clinical Neuroscience 15 (8): 923–7. August 2008. doi:10.1016/j.jocn.2007.03.013. PMID 18554912.
4. ↑ "An unusual case of brown tumor of hyperparathyroidism associated with ectopic parathyroid adenoma". European Journal of Dentistry 7 (4): 500–503. October 2013. doi:10.4103/1305-7456.120657. PMID 24932128.
5. ↑ "Images in clinical medicine. Brown tumor in end-stage renal disease". The New England Journal of Medicine 341 (22): 1652. November 1999. doi:10.1056/nejm199911253412204. PMID 10572153.
6. ↑ 6.0 6.1 "Oral pathology, 4th edition". European Journal of Orthodontics 27 (6): 615–616. December 2005. doi:10.1093/ejo/cji104. ;  Clinical facial analysis. Elements, principles and techniques. Heidelberg, Germany: Springer-Verlag GmbH. 2005. ISBN 978-0-19-852794-7.
7. ↑ "Bone disease in primary hyperparathyrodism". Therapeutic Advances in Musculoskeletal Disease 4 (5): 357–68. October 2012. doi:10.1177/1759720X12441869. PMID 23024712.
8. ↑ "A hemodialysis patient with bone disease after pregnancy: a case report". BMC Nephrology 20 (1): 425. November 2019. doi:10.1186/s12882-019-1603-8. PMID 31752733.
9. ↑ "Brown tumor of the thoracic spine presenting with paraplegia in a patient with peritoneal dialysis". CEN Case Reports 8 (4): 227–232. November 2019. doi:10.1007/s13730-019-00398-0. PMID 31089951.
10. ↑ "Brown Tumor". BoneTumor.org. http://www.bonetumor.org/tumors-disorder-metabolism/brown-tumor.

## External links

Classification|

* ICD-9-CM: 252.01
* MeSH: D010002
* DiseasesDB: 30721

|

* v
* t
* e

Bone and joint disease (M80–M94, 730–733)

Bone|

| Inflammation|

| endocrine:|

* Osteitis fibrosa cystica
* Brown tumor

|

infection:|

* Osteomyelitis
* Sequestrum
* Involucrum
* Sesamoiditis
* Brodie abscess
* Periostitis
* Vertebral osteomyelitis

Metabolic|

* Bone density
* Osteoporosis
* Juvenile
* Osteopenia
* Osteomalacia
* Paget's disease of bone

Bone resorption|

* Osteolysis
* Hajdu-Cheney syndrome
* Ainhum
* Gorham's disease

Other|

* Ischaemia
* Avascular necrosis
* Osteonecrosis of the jaw
* Algoneurodystrophy
* Hypertrophic pulmonary osteoarthropathy
* Nonossifying fibroma
* Pseudarthrosis
* Stress fracture
* Fibrous dysplasia
* Monostotic
* Polyostotic
* Skeletal fluorosis
* bone cyst
* Aneurysmal bone cyst
* Hyperostosis
* Infantile cortical hyperostosis
* Osteosclerosis
* Melorheostosis
* Pycnodysostosis

Joint|

| Chondritis|

* Relapsing polychondritis

|

Other|

* Tietze's syndrome

Combined|

| Osteochondritis|

* Osteochondritis dissecans

|

Child|

| leg:|

* hip
* Legg–Calvé–Perthes syndrome
* tibia
* Osgood-Schlatter disease
* Blount's disease
* foot
* Köhler disease
* Sever's disease

|

spine|

*     * Scheuermann’s disease

arm:|

* wrist
* Kienböck's disease
* elbow
* Panner disease

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