CNS demyelinating autoimmune diseases

The demyelination of the Central Nervous System

CNS demyelinating autoimmune diseases are autoimmune diseases which primarily affect the central nervous system.[1]

## Contents

* 1 Types
* 2 Presentation
* 3 Causes
* 4 Nervous System
* 5 Pathogenesis
* 6 Diagnosis
* 7 See also
* 8 References
* 9 External links

## Types

Examples include:

* Diffuse cerebral sclerosis of Schilder
* Acute disseminated encephalomyelitis
* Acute hemorrhagic leukoencephalitis
* Multiple sclerosis (though the cause is unknown, it is sure that immune system is involved)
* Transverse myelitis
* Neuromyelitis optica

## Presentation

Since the neural impulse is inhibited in this condition it may lead to paresthesia, muscle weakness, unsteady gait, paralysis, vision loss and other motor dysfunctions.

## Causes

CNS demyelination autoimmune disease causes the myelin sheath to deteriorate since the sense of recognition of self is lost. The loss of the myelin insulation either disrupts or prevents neural conduction along the nerve cell's axon.

## Nervous System

The brain and the spinal cord are the essential components of the central nervous system and it is responsible for the integration of the signals received from the afferent nerves and initiates action. The nerve cells, known as neurons, carry impulses throughout the body and the nerve impulses are carried along the axon. These microscopic nerve fibers, where the action potential occurs, are protected by a white, fatty tissue that surrounds and insulates it, known as the myelin sheath. This insulation helps the axon of a nerve cell with the conduction and speed of the signal along the axon.

## Pathogenesis

The pathogenesis of the demyelination can vary. Some of the factors that contribute to the deteriorating of the myelin are due to inflammatory processes, acquired metabolic derangements, viral demyelination, and hypoxic-ischaemic demyelination.

## Diagnosis

## See also

* Idiopathic inflammatory demyelinating diseases
* Demyelinating disease

## References

1. ↑ Demyelinating Autoimmune Diseases, CNS - MeSH - NCBI. https://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term="Demyelinating+Autoimmune+Diseases,+CNS"[MeSH+Terms].

## External links

Classification|

* MeSH: D020278

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* v
* t
* e

Multiple sclerosis and other demyelinating diseases of CNS (G35–G37, 340–341)

Signs and symptoms|

* Ataxia
* Dawson's fingers
* Depression
* Diplopia
* Dysarthria
* Dysphagia
* Fatigue
* Incontinence
* Neurological fatigue
* Nystagmus
* Optic neuritis
* Pain
* Uhthoff's phenomenon

Diagnosis and evolution following|

* Clinically isolated syndrome
* Diagnostic criteria for MS
* EDSS
* McDonald criteria
* Oligoclonal bands
* Poser criteria
* Radiologically isolated syndrome

Investigation|

* Experimental autoimmune encephalomyelitis
* Multiple sclerosis drug pipeline
* Multiple sclerosis research
* Pathophysiology

Approved treatment|

* Alemtuzumab
* Cladribine
* Dimethyl fumarate
* Fingolimod
* Glatiramer acetate
* Interferon beta-1a
* Interferon beta-1b
* Mitoxantrone
* Natalizumab
* Ocrelizumab
* Ozanimod
* Siponimod
* Teriflunomide

Former treatment|

* Daclizumab

Borderline forms|

* Acute disseminated encephalomyelitis
* AntiMOG associated encephalomyelitis
* Balo concentric sclerosis
* Marburg multiple sclerosis
* Neuromyelitis optica
* Oligoclonal negative MS
* Schilder's disease
* Tumefactive multiple sclerosis
* Some autoimmune PNS diseases like Guillain-Barré syndrome and CIDP normally set apart

Other|

* List of multiple sclerosis organizations
* List of people with multiple sclerosis

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