Chronic neutrophilic leukemia

Other names| CNL[1]
Specialty| Hematology and oncology

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that features a persistent neutrophilia in peripheral blood, myeloid hyperplasia in bone marrow, hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene.[2]

The cause of CNL is not known. It is diagnosed through laboratory findings such as peripheral blood neutrophilia and the presence of myeloid precursors in less than 5% of leukocytes. Bone marrow biopsy reveals a hypercellular marrow and an increased myeloid to erythroid ratio. Spleen and liver are also common sites of involvement. Less than 100 cases of CNL have been reported, affecting both genders equally and primarily occurring in older adults.

## Contents

* 1 Signs and symptoms
* 2 Cause
* 3 Genetics
* 4 Diagnosis
* 4.1 Laboratory findings
* 4.2 Sites of involvement
* 4.2.1 Bone marrow biopsy
* 4.2.2 Spleen
* 4.2.3 Liver
* 4.3 Immunophenotype
* 5 Epidemiology
* 6 References
* 7 External links

## Signs and symptoms

The most common clinical finding is hepatosplenomegaly. Pruritus, gout, and mucocutaneous bleeding are occasionally seen.[3][4]

## Cause

The cause of CNL is currently unknown. An association between CNL and multiple myeloma has been suggested based on the observation of myeloma in 20% of CNL cases.[5] However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the neutrophilia is a reaction due to the neoplastic myeloma cells.[2] The postulated cell of origin is a limited-potential, marrow-derived stem cell.[6]

## Genetics

The majority (90%) of cases have not had detectable cytogenetic abnormalities. Most importantly, the Philadelphia chromosome and other BCR/ABL fusion genes are not detected.[2]

## Diagnosis

### Laboratory findings

Peripheral blood neutrophilia (> 25 x 109/L) with myeloid precursors (promyelocytes, myelocytes, metamyelocytes) comprising less than 5% of leukocytes.[3][4]

### Sites of involvement

Peripheral blood, bone marrow, spleen, and liver are most common, but any organ or tissue can be infiltrated by neutrophils.[3] [4]

#### Bone marrow biopsy

On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:erythroid ratio of 20:1 or greater. Myelocytes and neutrophils are increased, and blasts and promyelocytes are not increased. Due to the myeloproliferative nature of the disease, an increase in megakaryocytes and erythroid precursors may be observed, but dyspoiesis in not seen in any cell lineage. Also, reticulin fibrosis is rare.[3][4] There is a reported association between CNL and multiple myeloma, so the bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells.[2]

#### Spleen

Splenic infiltrates are typically found only in the red pulp.[3] [4]

#### Liver

Hepatic infiltrates can be found in either the sinusoids, portal triad regions, or both.[3][4]

### Immunophenotype

No distinct immunophenotype abnormality for CNL has been described.[2] See OHSU 2013 findings of gene CSF3R, mutation p. T6181

## Epidemiology

This is a rare disease, with less than 100 cases reported. Of these cases, an equal male:female ratio was observed,[3] with cases typically seen in older adults.[4]

## References

1. ↑ "Chronic neutrophilic leukemia | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". https://rarediseases.info.nih.gov/diseases/10585/index. Retrieved 17 November 2019.
2. ↑ 2.0 2.1 2.2 2.3 2.4 Elaine Sarkin Jaffe, Nancy Lee Harris, World Health Organization, International Agency for Research on Cancer, Harald Stein, J.W. Vardiman (2001). Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors. 3. Lyon: IARC Press. ISBN 92-832-2411-6. https://books.google.com/books?id=XSKqcy7TUZUC.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 You, W.; Weisbrot, I. M. (August 1979). "Chronic neutrophilic leukemia. Report of two cases and review of the literature". American Journal of Clinical Pathology 72 (2): 233–42. doi:10.1093/ajcp/72.2.233. PMID 289288.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 "Chronic neutrophilic leukemia. A study of four cases". Ann. Hematol. 68 (2): 55–60. February 1994. doi:10.1007/BF01715131. PMID 8148416.
5. ↑ "Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta". J. Clin. Pathol. 46 (4): 297–8. April 1993. doi:10.1136/jcp.46.4.297. PMID 8098719.
6. ↑ "Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia". Am. J. Hematol. 57 (3): 221–4. March 1998. doi:10.1002/(SICI)1096-8652(199803)57:3<221::AID-AJH7>3.0.CO;2-X. PMID 9495373.

## External links

Classification|

* ICD-10: D47.1
* ICD-9-CM: 205.1
* ICD-O: M9963/3
* MeSH: D015467

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External resources|

* Orphanet: 86829

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