Contraction band necrosis

Short description: Medical condition

High magnification micrograph showing contraction band necrosis and karyolysis. H&E stain.

Contraction band necrosis is a type of uncontrolled cell death (necrosis) unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture.[1]

It is a characteristic histologic finding of a recent myocardial infarction (heart attack) that was partially reperfused.

The name of the histopathologic finding comes from the appearance under the microscope; contraction bands are thick intensely eosinophilic staining bands (typically 4-5 micrometres wide) that span the short axis of the myocyte. They can be thought of extra thick striae, typical of cardiac muscle and striated muscle.

## Contents

* 1 Pathophysiology
* 2 Additional images
* 3 See also
* 4 References
* 5 External links

## Pathophysiology

Contraction band necrosis is thought to arise by two mechanisms:[1]

1. a calcium-dependent mechanism - activation of the contractile machinery of the cell via its usual mechanism, calcium, which is in excess due to ischemia.
2. a calcium-independent mechanism, as seen in rigor mortis \- activation of the contractile machinery in the setting of low ATP.

Reperfusion associated cell death has been modulated (reduced) in animal studies[2] and is an area of active research, which holds the potential to significantly reduce the morbidity and mortality of cardiovascular disease.[1]

## Additional images

* Contraction band necrosis. H&E stain.

* Contraction band necrosis. PTAH.

## See also

* Myocardial infarction
* Timeline of myocardial infarction pathology
* Guanylyl cyclase

## References

1. ↑ 1.0 1.1 1.2 "Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction". Heart Fail Rev 12 (3-4): 207–16. December 2007. doi:10.1007/s10741-007-9039-9. PMID 17530396.
2. ↑ "Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion". Circulation 96 (10): 3579–86. November 1997. doi:10.1161/01.cir.96.10.3579. PMID 9396458.

## External links

* Contraction band necrosis \- pathologypics.com

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