Covivac (Vietnam COVID-19 vaccine)

Short description: Vaccine candidate against COVID-19

CovivacVaccine description

Target disease| SARS-CoV-2
Type| viral
Clinical data
Routes of
administration| Intramuscular

Covivac is a COVID-19 vaccine candidate developed by Institute of Vaccines and Medical Biologicals in Vietnam.[1][2][3]

## Contents

* 1 Description
* 2 Clinical trials
* 2.1 Phase I
* 2.2 Phase II
* 3 References
* 4 External links

## Description

Covivac is a viral vector (non-replicating), egg-based, inactivated vaccine (whole chimeric Newcastle Disease Virus (NDV) expressing membrane-anchored pre-fusion-stabilized trimeric SARS-CoV-2 S protein (Hexapro) + CpG 1018).[4] The vaccine requires two doses, the second one being administered 28 days after the first shot.[5]

## Clinical trials

### Phase I

On 21 January, the second Vietnam produced COVID-19 vaccine (Covivac) by Institute of Vaccine and Medical Biologicals (IVAC) has entered a human-clinical trial, nearly two months ahead of schedule. Covivac vaccine has been studied by IVAC since May 2020, has carried out pre-clinical trials in India, US and Vietnam, the results show safety and efficacy in experiment, fully meeting the conditions for conducting research with humans participants. The vaccine stability evaluation was conducted at Icahn School of Medicine at Mount Sinai, New York City.[6] Phase 1 recruited 120 healthy Vietnamese adult volunteers, aged 18–59.[7] On 15 March 2021, six volunteers were injected with the Covivac vaccine, at the Hà Nội Medical University. All 120 volunteers received the first dose, six of them received the second dose. Phase I will be completed on 15/5.[8] The research team recorded side effects from the volunteer's health, such as pain, fever, redness, headache, fatigue, muscle aches, and nausea. After 14 days infected second doses, the group of volunteers continued to get blood samples to test for antibodies.[9]

### Phase II

Phase two clinical trials may start in June 2021 in Vu Thu district, Thai Binh province.[10]

## References

1. ↑ "Second Việt Nam-produced COVID-19 vaccine to enter human trials this month". Vietnam News. January 5, 2021. https://vietnamnews.vn/society/852719/second-viet-nam-produced-covid-19-vaccine-to-enter-human-trials-this-month.html.
2. ↑ "Human trials start on second Vietnam-produced COVID-19 vaccine". Nhân Dân. March 15, 2021. https://en.nhandan.org.vn/society/item/9672102-human-trials-start-on-second-vietnam-produced-covid-19-vaccine.html.
3. ↑ "A Phase 1/2 Safety and Immunogenicity Trial of COVID-19 Vaccine COVIVAC". United States National Library of Medicine. https://clinicaltrials.gov/ct2/show/NCT04830800.
4. ↑ "Draft landscape and tracker of COVID-19 candidate vaccines". WHO. 30 March 2021. https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines?.
5. ↑ "Cập nhật tiến độ thử nghiệm lâm sàng 2 vắc xin phòng COVID-19 "made in" Việt Nam". Sức khỏe & Đời sống/Ministry of Health (Vietnam). 2021-04-07. https://suckhoedoisong.vn/cap-nhat-tien-do-thu-nghiem-lam-sang-2-vac-xin-phong-covid-19-made-in-viet-nam-n189523.html.
6. ↑ "Khởi động thử nghiệm vaccine phòng Covid-19 thứ 2 của Việt Nam" (in vi). Nhân Dân. 21 January 2021. https://nhandan.com.vn/tin-tuc-y-te/khoi-dong-thu-nghiem-vaccine-phong-covid-19-thu-2-cua-viet-nam-632446/.
7. ↑ "6 tình nguyện viên đầu tiên tiêm thử nghiệm vaccine COVIVAC vào sáng mai (15/3)". VOV. 2021-03-14. https://vov.vn/xa-hoi/tin-24h/6-tinh-nguyen-vien-dau-tien-tiem-thu-nghiem-vaccine-covivac-vao-sang-mai-153-843078.vov.
8. ↑ "6 tình nguyện viên tiêm thử nghiệm vaccine COVIVAC phòng COVID-19 của Việt Nam". https://moh.gov.vn/tin-noi-bat/-/asset_publisher/3Yst7YhbkA5j/content/6-tinh-nguyen-vien-tiem-thu-nghiem-vac-xin-covivac-phong-covid-19-cua-viet-nam.
9. ↑ "Tốc độ thử nghiệm Covivac nhanh hơn dự kiến". https://vnexpress.net/toc-do-thu-nghiem-covivac-nhanh-hon-du-kien-4268301.html.
10. ↑ "100% người tiêm thử Nanocovax sinh miễn dịch tốt". https://vnexpress.net/100-nguoi-tiem-thu-nanocovax-sinh-mien-dich-tot-4268114.html.

## External links

* v
* t
* e

Artificial induction of immunity / Immunization: Vaccines, Vaccination, Infection, Biology:Inoculat, Inoculation (J07)

Development|

* Adjuvants
* List of vaccine ingredients
* Mathematical modelling
* Timeline
* Trials

Classes|

* Conjugate vaccine
* DNA vaccination
* Inactivated vaccine
* Live vector vaccine
* Attenuated vaccine
* Heterologous vaccine
* Subunit/component / Peptide / Virus-like particle
* Toxoid

Administration|

* Global:
* GAVI Alliance
* Policy
* Schedule
* Vaccine injury
* USA:
* ACIP
* Vaccine court
* Vaccines for Children Program
* VAERS
* VSD

Vaccines|

| Bacterial|

* Anthrax
* Brucellosis
* Cholera#
* Diphtheria#
* Hib#
* Leptospirosis
* Lyme disease‡
* Meningococcus#
* MeNZB
* Medicine:NmVac4-A/C/Y/W-135
* Pertussis#
* Plague
* Pneumococcal#
* PCV
* PPSV
* Q fever
* Tetanus#
* Tuberculosis
* BCG#
* Typhoid#
* Ty21a
* ViCPS
* Typhus
* combination: DTwP/DTaP

|

Viral|

* Adenovirus
* Flu#
* H1N1 (Pandemrix)
* LAIV
* Hantavirus
* Hepatitis A#
* Hepatitis B#
* Hepatitis E
* HPV
* Cervarix
* Gardasil
* Japanese encephalitis#
* Measles#
* Mumps#
* Medicine:Mumpsvax
* Polio#
* Sabin
* Salk
* Rabies#
* Rotavirus#
* Rubella#
* Smallpox
* Medicine:Dryvax
* Tick-borne encephalitis
* Varicella zoster
* chicken pox#
* Zoster vaccine
* Yellow fever#
* combination:
* MMR
* MMRV
* research:
* Chikungunya
* Cytomegalovirus
* Dengue
* Ebola
* Epstein–Barr virus
* Hepatitis C
* HIV

Protozoan|

* Malaria
* RTS,S
* research:
* Trypanosomiasis

Helminthiasis|

* research:
* Hookworm
* Schistosomiasis

Other|

* Androvax (androstenedione albumin)
* Cancer vaccines
* ALVAC-CEA
* BCG#
* Hepatitis B#
* HPV
* Cervarix
* Gardasil
* PROSTVAC
* NicVAX
* Ovandrotone albumin (Fecundin)
* TA-CD
* TA-NIC
* combination
* DTaP-IPV/Hib
* DTaP-IPV-HepB
* Hexavalent vaccine
* Pentavalent vaccine

Controversy|

* General
* MMR
* NCVIA
* Pox party
* Thiomersal
* Vaccines and SIDS
* Lancet MMR autism fraud
* Cedillo v. Secretary of Health and Human Services
* Alternative vaccination schedule

Related|

* Epidemiology
* Eradication of infectious diseases
* Every Child by Two
* List of vaccine topics

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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