Diagnosis of Asperger syndrome

Short description: None

Several factors complicate the diagnosis of Asperger syndrome (AS), an autism spectrum disorder (ASD). Like other ASD forms, Asperger syndrome is characterized by impairment in social interaction accompanied by restricted and repetitive interests and behavior; it differs from the other ASDs by having no general delay in language or cognitive development. Problems in diagnosis include disagreement among diagnostic criteria, the controversy over the distinction between AS and other ASD forms or even whether AS exists as a separate syndrome, and over- and under-diagnosis for non-technical reasons. As with other ASD forms, early diagnosis is important, and differential diagnosis must consider several other conditions.

## Contents

* 1 Criteria
* 2 Reliability
* 3 Procedure
* 4 Early diagnosis
* 5 Differential diagnosis
* 6 Multiple sets of diagnostic criteria
* 7 Differences from high-functioning autism
* 8 DSM-5 changes
* 9 References
* 10 Further reading

## Criteria

Asperger syndrome is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) as a pervasive developmental disorder that is distinguished by a pattern of symptoms rather than a single symptom. It is characterized by impairment in social interaction, by stereotyped and restricted patterns of behavior, activities and interests, and by no clinically significant delay in cognitive development or general delay in language. Impairments must be significant, and must affect important areas of function, and the diagnosis is excluded if criteria are also met for autism.[1] Intense preoccupation with a narrow subject, one-sided verbosity, restricted prosody, and physical clumsiness are typical of the condition, but are not required for diagnosis.[2]

The World Health Organization ICD-10 criteria are almost identical to DSM-IV:[3] ICD-10 adds the statement that motor clumsiness is usual (although not necessarily a diagnostic feature); ICD-10 adds the statement that isolated special skills, often related to abnormal preoccupations, are common but are not required for diagnosis; and the DSM-IV requirement for clinically significant impairment in social, occupational, or other important areas of functioning is not included in ICD-10.[4][5]

Diagnosis of Asperger syndrome can be tricky as there is a lack of standardized diagnostic screening for the disorder.[6] According to the US National Institute of Neurological Disorders and Stroke, physicians look for the presence of a primary group of behaviors to make a diagnosis such as abnormal eye contact, aloofness, failure to respond when called by name, failure to use gestures to point or show, lack of interactive play with others, and a lack of interest in peers.

## Reliability

The diagnoses of AS or high-functioning autism (HFA) are sometimes used interchangeably; the same child can receive different diagnoses depending on the screening tool and the individual administering the test.[6] Diagnoses may be influenced by non-technical issues, such as the availability of government benefits for one condition but not the other.[7] Advocacy and parent support organizations have proliferated around the concept of AS, and there are indications that this has resulted in more frequent diagnoses of AS, which may be given as a "residual diagnosis" to children of normal intelligence who do not meet diagnostic criteria for autism but have some social difficulties.[2] Conversely, the cost of screening and diagnosis and the challenge of obtaining payment can inhibit or delay diagnosis.[8]

## Procedure

Developmental screening during a routine check-up by a general practitioner or pediatrician may identify signs that warrant further investigation. This will require a comprehensive team evaluation to either confirm or exclude a diagnosis of AS. This team usually includes a psychologist, neurologist, psychiatrist, speech and language pathologist, occupational therapist and other professionals with expertise in diagnosing children with AS.[5][6] Observation occurs across multiple settings; the social disability in AS may be more evident during periods when social expectations are unclear and children are free of adult direction.[9] A comprehensive evaluation includes neurological and genetic assessment, with in-depth cognitive and language testing to establish IQ and evaluate psychomotor function, verbal and nonverbal strengths and weaknesses, style of learning, and skills for independent living. An assessment of communication strengths and weaknesses includes the evaluation of nonverbal forms of communication (gaze and gestures); the use of non-literal language (metaphor, irony, absurdities and humor); patterns of speech inflection, stress and volume; pragmatics (turn-taking and sensitivity to verbal cues); and the content, clarity and coherence of conversation.[6] Testing may include an audiological referral to exclude hearing impairment. The determination of whether there is a family history of autism spectrum conditions is important.[10] A medical practitioner will diagnose on the basis of the test results and the person's developmental history and current symptoms.[6] Because multiple domains of functioning are involved, a multidisciplinary team approach is critical;[3] an accurate assessment of the individual's strengths and weaknesses is more useful than a diagnostic label.[9] Delayed or mistaken diagnosis is a serious problem that can be traumatic for individuals and families; diagnosis based solely on neurological, speech and language, or educational attainment may yield only a partial diagnosis.[3]

Advances in genetic technology allow clinical geneticists to link an estimated 40% of ASD cases to genetic causes; in one study the diagnostic yield for AS, PDD-NOS and atypical autism was similar to that for classic autism.[11] Genetic diagnosis is relatively expensive,[11] and genetic screening is generally impractical. As genetic tests are developed several ethical, legal, and social issues will emerge. Commercial availability of tests may precede adequate understanding of how to use test results, given the complexity of the genetics.[12]

## Early diagnosis

Parents of children with AS can typically trace differences in their children's development to as early as 30 months of age, although diagnosis is not made on average until the age of 11.[10] By definition, children with AS develop language and self-help skills on schedule, so early signs may not be apparent and the condition may not be diagnosed until later childhood or adulthood. Impairment in social interaction is sometimes not in evidence until a child attains an age at which these behaviors become important; social disabilities are often first noticed when children encounter peers in daycare or preschool.[9] Diagnosis is most commonly made between the ages of four and eleven, and one study suggests that diagnosis cannot be rendered reliably before age four.[9]

## Differential diagnosis

Asperger syndrome can be misdiagnosed as a number of other conditions, leading to medications that are unnecessary or even worsen behavior; the condition may be at the root of treatment-resistant mental illness in adults. Diagnostic confusion burdens individuals and families and may cause them to seek unhelpful therapies. Conditions that must be considered in a differential diagnosis include other pervasive developmental disorders (autism, PDD-NOS, childhood disintegrative disorder, Rett disorder), schizophrenia spectrum disorders (schizophrenia, schizotypal disorder, schizoid personality disorder), attention-deficit hyperactivity disorder, obsessive compulsive disorder, depression, semantic pragmatic disorder, multiple complex developmental disorder and nonverbal learning disorder (NLD).[3]

Differentiating between AS and other ASDs relies on the judgment of experienced clinicians.[9] There is much overlap between AS and NLD: both have symptoms of precocious reading, verbosity, and clumsiness, but they differ in that children with AS have restricted interests, repetitive behaviors, and less-typical social interactions.[13] Tourette syndrome (TS) should also be considered in differential diagnosis: "It is in nonretarded, rigid individuals on the autistic spectrum, especially those with so-called Asperger syndrome, that differences with less severely affected individuals with TS and obsessive compulsive disorder may become blurred, or that both disorders may coexist."[14] Other problems to be considered in the differential diagnosis include selective mutism, stereotypic movement disorder and bipolar disorder[10] as well as traumatic brain injury or birth trauma, conduct disorder, Cornelia De Lange syndrome, fetal alcohol syndrome, fragile X syndrome, dyslexia, Fahr syndrome, hyperlexia, leukodystrophy, multiple sclerosis and Triple X syndrome.[15]

## Multiple sets of diagnostic criteria

The diagnosis of AS is complicated by the use of several different screening instruments.[6][16] In addition to the DSM-IV and the ICD-10 criteria, other sets of diagnostic criteria for AS are the Szatmari et al. criteria[17] and the Gillberg and Gillberg criteria.[18]

Partial Diagnostic Criteria for Asperger Syndrome
Adapted from Mattila et al.[4]
Blank = not defined by the criteria
Substantial differences between criteria listed:
all sub-sections of criteria not included

| DSM-IV  | ICD-10  | Gillberg  | Szatmari
Language delay  | No  | No  | Maybe  |
Cognitive development delay  | No  | No  |  |
Self-help skill delay  | No  | No  |  |
Social interaction impairment  | Yes  | Yes  | Yes  | Yes
– Impaired nonverbal communication  | Maybe  | Maybe  | Yes  | Yes
– Inadequate friendships  | Maybe  | Maybe  | Maybe  | Yes
Repetitive, stereotyped behavior  | Yes  | Yes  | Yes  |
– All-absorbing interest  | Maybe  | Maybe  | Yes  |
– Routines or rituals  | Maybe  | Maybe  | Yes  |
Odd speech  |  |  | Yes  | Yes
Motor clumsiness  |  | Maybe  | Yes  |
Isolated special skills  |  | Common  |  |
Clinically significant impairmenta | Yes  |  |  |
Exclusion of other disorder  | Yesb | Yesc | No  | Yesd
a Impairment in social, occupational, or other important areas of functioning
b Does not meet criteria for another pervasive developmental disorder or schizophrenia
c Not attributed to pervasive developmental disorder, schizotypal disorder, simple schizophrenia, reactive and disinhibited attachment disorder, obsessional personality disorder, obsessive compulsive disorder
d Does not meet criteria for autistic disorder

Compared with the DSM-IV and ICD-10 criteria, the requirements of normal early language and cognitive development are not mentioned by Szatmari et al., whereas language delay is allowed in the Gillberg and Gillberg criteria. Szatmari et al. emphasize solitariness, and both Gillberg and Szatmari include "odd speech" and "language" in their criteria. Although Szatmari does not mention stereotyped behaviors, one of four described stereotyped functions is required by DSM-IV and ICD-10, and two are required by Gillberg and Gillberg. Abnormal responses to sensory stimuli are not mentioned in any diagnostic scheme, although they have been associated with AS.[4] Because DSM-IV and ICD-10 exclude speech and language difficulties, these definitions exclude some of the original cases described by Hans Asperger. According to one researcher, the majority of individuals with AS do have speech and language abnormalities, and the DSM-IV-TR says that "the occurrence of 'no clinically significant delays in language does not imply that individuals with Asperger Disorder have no problems with communication' (American Psychiatric Association, 2000, p. 80)".[3] The Gillberg and Gillberg criteria are considered closest to Asperger's original description of the syndrome;[3] the aggression and abnormal prosody that other authors say defined Asperger's patients are not mentioned in any criteria.[5][9][19]

The DSM-IV and ICD-10 diagnostic criteria have been criticized for being too broad and inadequate for assessing adults,[20] overly narrow (particularly in relation to Hans Asperger's original description of individuals with AS),[3][21] and vague;[16] results of a large study in 2007 comparing the four sets of criteria point to a "huge need to reconsider the diagnostic criteria of AS".[4] The study found complete overlap across all sets of diagnostic criteria in the impairment of social interaction with the exception of four cases not diagnosed by the Szatmari et al. criteria because of its emphasis on social solitariness. Lack of overlap was strongest in the language delay and odd speech requirements of the Gillberg and the Szatmari requirements relative to DSM-IV and ICD-10, and in the differing requirements regarding general delays.[4] A small 2008 study of children referred with a tentative diagnosis of AS found poor agreement among the four sets of criteria, with one overlap being only 39%.[22] In 2007 Szatmari et al. suggested a new classification system of ASD based on familial traits found by genetic epidemiology.[23]

## Differences from high-functioning autism

This book may need to be updated to reflect current knowledge.

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The distinction between Asperger's and other ASD forms is to some extent an artefact of how autism was discovered.[24] Although individuals with Asperger's tend to perform better cognitively than those with autism, the extent of the overlap between Asperger's and high-functioning autism is unclear.[2][25] Overall, relatively few differences are reported between Asperger's and autism on parameters related to causation. A standard assumption is that Asperger's and autism have a common cause, and are variable expressions of the same underlying disorder.[26] A 2008 review of classification studies found that results largely did not support differences between the diagnoses, and that the most salient group characteristics came from IQ characterizations.[25] The current ASD classification may not reflect the true nature of the conditions.[27] A panel session at a 2008 diagnosis-related autism research planning conference noted problems with the classification of AS as a distinct subgroup of ASD, and two of three breakout groups recommended eliminating AS as a separate diagnosis.[28]

A neuropsychological profile has been proposed for AS;[29] if verified, it could differentiate between AS and HFA and aid in differential diagnosis. Relative to HFA, people with AS have deficits in nonverbal skills such as visual-spatial problem solving and visual-motor coordination,[30] along with stronger verbal abilities.[31] Several studies have found AS with a neuropsychologic profile of assets and deficits consistent with a nonverbal learning disability, but several other studies have failed to replicate this.[30] The literature review did not reveal consistent findings of "nonverbal weaknesses or increased spatial or motor problems relative to individuals with HFA", leading some researchers to argue that increased cognitive ability is evidenced in AS relative to HFA regardless of differences in verbal and nonverbal ability.[32]

## DSM-5 changes

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) which was published in May 2013 canceled Asperger's disorder as a separate diagnosis and homogenized it under autism spectrum disorder, with severity measures within the broader diagnosis.[33][34] The DSM 5 noted that "Individuals with a well-established DSM-IV diagnosis of [...] Asperger's disorder [...] should be given the diagnosis of autism spectrum disorder."[35]

The removal of Asperger's Disorder from the DSM has been controversial as it is commonly used by health insurers, researchers, state agencies, schools, and individuals with the disorder.[33] Experts are concerned that eliminating the Asperger's label will prevent mildly affected people from being evaluated for Autism.[33] A meta-analysis of 14 studies published The Columbia University school of nursing in early 2014 showed that there was a pooled 30% decrease in Autism Spectrum Disorder diagnoses following the publication of the DSM 5.[34]

## References

1. ↑ American Psychiatric Association (2000). "Diagnostic criteria for 299.80 Asperger's Disorder (AD)". Diagnostic and Statistical Manual of Mental Disorders (4th, text revision (DSM-IV-TR) ed.). American Psychiatric Association. ISBN 978-0-89042-025-6. http://www.behavenet.com/capsules/disorders/asperger.htm. Retrieved 2007-06-28.
2. ↑ 2.0 2.1 2.2 Klin A (2006). "Autism and Asperger syndrome: an overview". Rev Bras Psiquiatr 28 (suppl 1): S3–S11. doi:10.1590/S1516-44462006000500002. PMID 16791390.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 "Diagnosis and differential diagnosis of Asperger syndrome". Adv Psychiatric Treat 7 (4): 310–8. 2001. doi:10.1192/apt.7.4.310. http://apt.rcpsych.org/cgi/content/full/7/4/310.
4. ↑ 4.0 4.1 4.2 4.3 4.4 Mattila ML; Kielinen M; Jussila K et al. (2007). "An epidemiological and diagnostic study of Asperger syndrome according to four sets of diagnostic criteria". J Am Acad Child Adolesc Psychiatry 46 (5): 636–46. doi:10.1097/chi.0b013e318033ff42. PMID 17450055.
5. ↑ 5.0 5.1 5.2 "Asperger syndrome revisited". Rev Neurol Dis 3 (1): 1–7. 2006. PMID 16596080.
6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 "Asperger Syndrome Fact Sheet". ninds.nih.gov. http://www.ninds.nih.gov/disorders/asperger/detail_asperger.htm.
7. ↑ Attwood, T (2003). Is There a Difference Between Asperger's Syndrome and High Functioning Autism? (PDF). Sacramento Asperger Syndrome Information & Support. Retrieved 2007-08-15.
8. ↑ "Issues related to the diagnosis and treatment of autism spectrum disorders". Ment Retard Dev Disabil Res Rev 13 (2): 129–35. 2007. doi:10.1002/mrdd.20143. PMID 17563895.
9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 "Asperger's syndrome". Adolesc Med Clin 17 (3): 771–88. 2006. doi:10.1016/j.admecli.2006.06.010. PMID 17030291.
10. ↑ 10.0 10.1 10.2 "Asperger syndrome: to be or not to be?". Curr. Opin. Pediatr. 15 (5): 491–94. 2003. doi:10.1097/00008480-200310000-00008. PMID 14508298.
11. ↑ 11.0 11.1 "Genetics evaluation for the etiologic diagnosis of autism spectrum disorders". Genet Med 10 (1): 4–12. 2008. doi:10.1097/GIM.0b013e31815efdd7. PMID 18197051.
12. ↑ "Genetic counseling and ethical issues for autism". Am J Med Genet C Semin Med Genet 142C (1): 52–7. 2006. doi:10.1002/ajmg.c.30082. PMID 16419100.
13. ↑ "When Asperger's syndrome and a nonverbal learning disability look alike". J Dev Behav Pediatr 25 (3): 190–5. 2004. doi:10.1097/00004703-200406000-00008. PMID 15194904.
14. ↑ Rapin I (2001). "Autism spectrum disorders: relevance to Tourette syndrome". Advances in Neurology 85: 89–101. PMID 11530449.
15. ↑ Brasic, JR. Pervasive Developmental Disorder: Asperger Syndrome. eMedicine.com (April 10, 2006). Retrieved 15 July 2007.
16. ↑ 16.0 16.1 "The epidemiology of Asperger's syndrome. A total population study". J Child Psychol Psychiatry 34 (8): 1327–50. 1993. doi:10.1111/j.1469-7610.1993.tb02094.x. PMID 8294522. "Truncated version". http://asperger.org/Publications/Ehlers_and_Gillberg_Article.asp.
17. ↑ "Asperger's syndrome: a review of clinical features". Canadian Journal of Psychiatry 34 (6): 554–60. 1989. doi:10.1177/070674378903400613. PMID 2766209.
18. ↑ "Asperger syndrome-some epidemiological considerations: A research note". J Child Psychol Psychiatry 30 (4): 631–38. Jul 1989. doi:10.1111/j.1469-7610.1989.tb00275.x. PMID 2670981.
19. ↑ "A retrospective analysis of the clinical case records of 'autistic psychopaths' diagnosed by Hans Asperger and his team at the University Children's Hospital, Vienna". Philos. Trans. R. Soc. Lond. B Biol. Sci. 358 (1430): 291–301. 2003. doi:10.1098/rstb.2002.1197. PMID 12639327.
20. ↑ "The Adult Asperger Assessment (AAA): a diagnostic method". Journal of Autism and Developmental Disorders 35 (6): 807–19. 2005. doi:10.1007/s10803-005-0026-5. PMID 16331530. http://www.autismresearchcentre.com/docs/papers/2006_BCetal_AAA.pdf. Retrieved 2007-09-04.
21. ↑ "Does DSM-IV Asperger's disorder exist?". Journal of Abnormal Child Psychology 29 (3): 263–71. 2001. doi:10.1023/A:1010337916636. PMID 11411788.
22. ↑ Kopra K; von Wendt L; Nieminen–von Wendt T; Paavonen EJ (2008). "Comparison of diagnostic methods for Asperger syndrome". J Autism Dev Disord 38 (8): 1567–73. doi:10.1007/s10803-008-0537-y. PMID 18324466.
23. ↑ "The use of genetic epidemiology to guide classification in child and adult psychopathology". Int Rev Psychiatry 19 (5): 483–96. 2007. doi:10.1080/09540260701563619. PMID 17896229.
24. ↑ Sanders JL (2009). "Qualitative or quantitative differences between Asperger's Disorder and autism? historical considerations". J Autism Dev Disord 39 (11): 1560–7. doi:10.1007/s10803-009-0798-0. PMID 19548078.
25. ↑ 25.0 25.1 "Examining the validity of autism spectrum disorder subtypes". J Autism Dev Disord 38 (9): 1611–24. 2008. doi:10.1007/s10803-008-0541-2. PMID 18327636.
26. ↑ "The autistic spectrum: subgroups, boundaries, and treatment". Psychiatr Clin North Am 25 (4): 811–36. 2002. doi:10.1016/S0193-953X(02)00020-5. PMID 12462862.
27. ↑ Szatmari P (2000). "The classification of autism, Asperger's syndrome, and pervasive developmental disorder". Can J Psychiatry 45 (8): 731–38. doi:10.1177/070674370004500806. PMID 11086556. http://ww1.cpa-apc.org:8080/Publications/Archives/CJP/2000/Oct/Classification.asp.
28. ↑ First MB (2008). "Autism and Other Pervasive Developmental Disorders Conference (February 3–5, 2008)". American Psychiatric Association. http://psych.org/MainMenu/Research/DSMIV/DSMV/DSMRevisionActivities/ConferenceSummaries/AutismConference.aspx.
29. ↑ Reitzel J, Szatmari P. "Cognitive and academic problems." In: Prior M, editor. Learning and behavior problems in Asperger syndrome. New York: Guilford Press; 2003. p. 35–54, as cited in McPartland J, Klin A (2006), p. 774.
30. ↑ 30.0 30.1 "Asperger syndrome: diagnosis and external validity". Child Adolesc Psychiatr Clin N Am 12 (1): 1–13. 2003. doi:10.1016/S1056-4993(02)00052-4. PMID 12512395.
31. ↑ "Defining the intellectual profile of Asperger Syndrome: comparison with high-functioning autism". Journal of Autism and Developmental Disorders 34 (3): 279–84. 2004. doi:10.1023/B:JADD.0000029550.19098.77. PMID 15264496. ; Ehlers S; Nydén A; Gillberg C et al. (1997). "Asperger syndrome, autism and attention disorders: a comparative study of the cognitive profiles of 120 children". Journal of Child Psychology and Psychiatry, and Allied Disciplines 38 (2): 207–17. doi:10.1111/j.1469-7610.1997.tb01855.x. PMID 9232467. as cited in McPartland J, Klin A (2006), p. 775.
32. ↑ "The external validity of Asperger disorder: lack of evidence from the domain of neuropsychology". Journal of Abnormal Psychology 109 (2): 227–38. 2000. doi:10.1037/0021-843X.109.2.227. PMID 10895561. as cited in McPartland J, Klin A (2006), p. 775.
33. ↑ 33.0 33.1 33.2 Wallis C (2009-11-02). "A Powerful Identity, a Vanishing Diagnosis". New York Times. https://www.nytimes.com/2009/11/03/health/03asperger.html.
34. ↑ 34.0 34.1 Medscape More Evidence DSM-5 May Significantly Reduce Autism Dx March 7, 2014
35. ↑ U.S. Department of Health & Human Services Interagency Autism Coordinating Committee

## Further reading

* Johnson CP, Myers SM, Council on Children with Disabilities (2007). "Identification and evaluation of children with autism spectrum disorders". Pediatrics 120 (5): 1183–215. doi:10.1542/peds.2007-2361. PMID 17967920. http://pediatrics.aappublications.org/cgi/content/full/120/5/1183.

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