Drug-induced angioedema

Other names| Acquired angioedema
Specialty| Dermatology

Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and some neprilysin inhibitors.[1][2] The angioedema appears to be dose dependent as it may resolve with decreased dose.[1]

## Contents

* 1 Presentation
* 2 Risk factor
* 3 Incidence
* 4 See also
* 5 References
* 6 External links

## Presentation

Angioedema presents itself as an abrupt onset of non-pitting, non-itchy swelling that involves the mucosal layers. Some common locations of angioedema are the face, particularly the lips and around the eyes, hands and feet, and genitalia.[3] A rare, yet serious complication is one inside the abdomen, the symptom usually being severe stomach upset, which is much less obvious than the other locations.[4]

## Risk factor

Some common ACE Inhibitors are:

* Benazepril (Lotensin)
* Captopril (Capoten)
* Enalapril (Vasotec)
* Lisinopril (Prinivil, Zestril)
* Ramipril (Altace)

Some common ARBs are:

* Candesartan (Atacand)
* Losartan (Cozaar)
* Olmesartan (Benicar)
* Valsartan (Diovan)

## Incidence

Cases of drug-induced angioedema are uncommon, with studies showing an incidence of less than 1%.[5] The reason this adverse effect may occur is due to the build-up of bradykinin, a vasodilator. This causes blood vessels to dilate and allows for fluid buildup in the mucosal surfaces.

## See also

* Angioedema
* Skin lesion

## References

1. ↑ 1.0 1.1 James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. p. 120. ISBN 0-7216-2921-0.
2. ↑ Campbell, Duncan J. (2018-09-19). "Neprilysin Inhibitors and Bradykinin". Frontiers in Medicine 5: 257. doi:10.3389/fmed.2018.00257. ISSN 2296-858X. PMID 30283782.
3. ↑ Winters, Michael. “Clinical Practice Guideline: Initial Evaluation and Management of Patients Presenting
4. ↑ J Community Hosp Intern Med Perspect. 2014; 4(4): 10.3402/jchimp.v4.25260
5. ↑ Banerji, Aleena. “Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department.” Annals of Allergy, Asthma & Immunology (2008); 100: 327-332. Web. 2 Nov 2014

## External links

Classification|

* ICD-10: T78.3
* OMIM: 300909

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External resources|

* Orphanet: 91385

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