Fabry disease

Short description: Rare human genetic lysosomal storage disorder

Fabry disease

Other names| Fabry's disease, Anderson–Fabry disease, angiokeratoma corporis diffusum, alpha-galactosidase A deficiency
Alpha galactosidase - the deficient protein in Fabry disease
Pronunciation|

* /ˈfɑːbri/

Specialty| Medical Genetics
Complications| Heart failure, abnormal heart rhythms
Usual onset| Childhood
Causes| Genetic
Diagnostic method| Enzyme activity assay, genetic testing
Differential diagnosis| Hypertrophic cardiomyopathy
Treatment| Enzyme replacement

Fabry disease, also known as Anderson–Fabry disease, is a rare genetic disease that can affect many parts of the body, including the kidneys, heart, brain, and skin.[1] Fabry disease is one of a group of conditions known as lysosomal storage diseases. The genetic mutation that causes Fabry disease interferes with the function of an enzyme that processes biomolecules known as sphingolipids, leading to these substances building up in the walls of blood vessels and other organs. It is inherited in an X-linked manner.

Fabry disease is sometimes diagnosed using a blood test that measures the activity of the affected enzyme called alpha-galactosidase, but genetic testing is also sometimes used, particularly in females.

The treatment for Fabry disease varies depending on the organs affected by the condition, and the underlying cause can be addressed by replacing the enzyme that is lacking.

The first descriptions of the condition were made simultaneously by dermatologist Johannes Fabry[2] and the surgeon William Anderson[3] in 1898.[4]

## Contents

* 1 Signs and symptoms
* 1.1 Pain
* 1.2 Kidney
* 1.3 Heart
* 1.4 Skin
* 1.5 Other manifestations
* 2 Causes
* 3 Mechanism
* 4 Diagnosis
* 5 Treatment
* 5.1 Therapies targeting enzyme activity
* 5.2 Organ-specific treatment
* 6 Prognosis
* 7 Epidemiology
* 8 Research
* 8.1 GT-GLA-S03
* 9 History
* 10 Society and culture
* 11 References
* 12 Further reading
* 13 External links

## Signs and symptoms

A bilateral, whorl-like corneal pattern of cream-colored lines in a person with Fabry disease Angiokeratoma, a common skin manifestation in Fabry disease

Symptoms are typically first experienced in early childhood and can be very difficult to diagnose; the rarity of Fabry disease to many clinicians sometimes leads to misdiagnoses. Manifestations of the disease usually increase in number and severity as an individual ages.[5]

### Pain

Full-body or localized pain to the extremities (known as acroparesthesia) or gastrointestinal (GI) tract is common in patients with Fabry disease. This pain can increase over time. This acroparesthesia is believed to be related to the damage of peripheral nerve fibers that transmit pain. Gastrointestinal tract pain is likely caused by the accumulation of lipids in the small vasculature of the GI tract, which obstructs blood flow and causes pain.[6]

### Kidney

### Heart

Fabry disease can affect the heart in several ways. The accumulation of sphingolipids within heart muscle cells causes an abnormal thickening of the heart muscle or hypertrophy. This hypertrophy can cause the heart muscle to become abnormally stiff and unable to relax, leading to a hypertrophic cardiomyopathy causing shortness of breath.[7][8]

Fabry disease can also affect how the heart conducts electrical impulses, leading to both abnormally slow heart rhythms such as complete heart block, and abnormally rapid heart rhythms such as ventricular tachycardia. These abnormal heart rhythms can cause blackouts, palpitations, or even sudden cardiac death.[7][8]

Sphingolipids can also build up within the heart valves, thickening the valves and affecting the way they open and close. If severe, this can cause the valves to leak (regurgitation) or restrict the forward flow of blood (stenosis). The aortic and mitral valves are more commonly affected than the valves on the right side of the heart.[7][8]

### Skin

Angiokeratomas (tiny, painless papules that can appear on any region of the body, but are predominant on the thighs, around the navel, buttocks, lower abdomen, and groin) are common.[9]

Ocular involvement may be present showing cornea verticillata (also known as vortex keratopathy), i.e. clouding of the corneas. Keratopathy may be the presenting feature in asymptomatic patients and must be differentiated from other causes of vortex keratopathy (e.g. drug deposition in the cornea).[10] This clouding does not affect vision.[10]

### Other manifestations

## Causes

Fabry disease is caused by a mutation in the DNA sequence of the GLA gene. A person who inherits this mutation does not have enough of a functioning enzyme known as alpha-galactosidase A. The lack of alpha-galactosidase leads to Fabry disease. A deficiency of alpha-galactosidase A (a-GAL A, encoded by GLA) due to mutation causes a glycolipid known as globotriaosylceramide (abbreviated as Gb3, GL-3, or ceramide trihexoside) to accumulate within the blood vessels, other tissues, and organs.[11] This accumulation leads to an impairment of their proper functions. At least 443 disease-causing mutations in the GLA gene have been discovered.[12] The DNA mutations that cause the disease are X-linked recessive with incomplete penetrance in heterozygous females. The condition affects hemizygous males (i.e. all non-intersex males), as well as homozygous, and in many cases heterozygous females. While males typically experience severe symptoms, women can range from being asymptomatic to having severe symptoms. Research suggests many women experience severe symptoms ranging from early cataracts or strokes to hypertrophic left ventricular heart problems and kidney failure. This variability is thought to be due to X-inactivation patterns during embryonic development of the female.[13]

## Mechanism

Fabry disease is an inherited lysosomal storage disorder that is caused by a deficiency of alpha-galactosidase A. This enzyme deficiency results in the accumulation of glycosphingolipids found in the lysosomes of most cell types and tissues, manifesting as a multisystem disease. Symptoms include painful crisis, angiokeratomas, corneal dystrophy, and hypohidrosis.[14] In severe cases there is renal, cerebrovascular, and cardiac involvement.[14] Fabry disease is X-linked and manifests mostly in homozygous males but also in heterozygous females. Cardiac involvement is common in Fabry disease, and is the main cause of premature mortality among patients. Patients can develop hypertrophic cardiomyopathy, arrhythmias, conduction abnormalities, and valvular abnormalities.[14] Deficient activity of lysosomal alpha-galactosidase results in progressive accumulation of globotriaosylceramide (GL-3) within lysosomes, that is believed to trigger a cascade of cellular events.[15] The demonstration of marked alpha-galactosidase deficiency is the conclusive method for the diagnosis in homozygous males. It may be detected in heterozygous females, but it is often inconclusive due to random X-chromosomal inactivation, so molecular testing (genotyping) of females is mandatory.[15]

## Diagnosis

Fabry disease is suspected based on the individual's clinical presentation and can be diagnosed by an enzyme assay (usually done on leukocytes) to measure the level of alpha-galactosidase activity. An enzyme assay is not reliable for the diagnosis of disease in females due to the random nature of X-inactivation. Molecular genetic analysis of the GLA gene is the most accurate method of diagnosis in females, particularly if the mutations have already been identified in male family members. Many disease-causing mutations have been noted. Kidney biopsy may also be suggestive of Fabry disease if excessive lipid buildup is noted. Pediatricians, as well as internists, commonly misdiagnose Fabry disease.[16] All immediate and extended family members in the same family have the same family mutation, so if one member of a family has a DNA sequence analysis performed, other members of the family can be diagnosed by performing a targeted sequence analysis instead of testing the entire gene.[17] Targeted sequencing is quicker and less expensive to perform. One study reported that for every first diagnosis in a family, on average five more family members (immediate and extended) are also diagnosed.[17]

MRI is accurate in accessing left ventricular mass and thickness and hypertrophy. Late gadolinium enhancement shows an increased signal of the mid wall at the inferolateral wall of the base of the left ventricle, usually in the non-hypertrophic ventricle. T1-weighted imaging can show low T1 signal due to sphingolipid storage in the heart even without ventricular hypertrophy in 40% of those affected by the disease. Thus, MRI is a useful way of diagnosing the disease early.[18] T2 signal is increased in inflammation and oedema.[19]

## Treatment

### Therapies targeting enzyme activity

* Enzyme replacement therapy is designed to provide the enzyme the patient is missing as a result of a genetic malfunction. This treatment is not a cure, but can partially prevent disease progression, and potentially reverse some symptoms.[20] As of March 2022[update], three medical drugs based on enzyme replacement therapy are available for Fabry disease:
* Agalsidase alfa, sold under the brand name Replagal by the company Takeda (since its acquisition of the company Shire), is a recombinant form of alpha-galactosidase A[21] It received approval in the EU in 2001.[22] FDA approval was applied for the United States.[23] However, Shire withdrew their application for approval in the United States in 2012, citing that the agency will require additional clinical trials before approval.[24] As of March 2022[update], Replagal has not received FDA approval.[25]
* Agalsidase beta, sold under the brand name Fabrazyme by the company Sanofi, is another recombinant form of alpha-galactosidase. Like replagal, it received approval in the EU in 2001.[26] In 2003, it was the first treatment for Fabry disease to be approved by the FDA.[27]
* Pegunigalsidase alfa (Elfabrio) was approved for medical use in the European Union in May 2023.[28]

Clinically, agalsidase alfa and agalsidase beta are generally similar in effectiveness and safety,[29] however they have never been compared directly in a randomized trial.[30] Both are given by intravenous infusion every two weeks.[22][26] They are available in Europe and in many other parts of the world, but treatment costs remain very high.[31]

* Pharmacological chaperone therapy is another strategy to maintain enzyme activity. It does so by assisting correct folding of alpha-galactosidase despite the mutations that cause Fabry disease. As of March 2022[update], one medical drug based on pharmacological chaperone therapy is available for Fabry disease:
* Migalastat, sold under the brand name Galafold by the company Amicus Therapeutics, is a pharmacological chaperone that can stabilize many mutant forms of alpha-galactosidase. It is taken by mouth. In a randomized trial comparing Migalastat with enzyme replacement therapy, the efficacy and safety of both treatments were similar.[32][33] The US Food and Drug Administration (FDA) granted Galafold orphan drug status in 2004,[34] and the European Commission followed in 2006.[35] The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) granted the drug a marketing approval under the name Galafold in May 2016.[36][37][38] FDA approval followed in 2018.[39]
* Experimental therapies that are not approved for treatment as of March 2022[update] include the following:
* A gene therapy treatment that is in early-phase clinical trials,[40][41] with the technology licensed to AvroBio.[42]
* The substrate reduction therapy Venglustat (Ibiglustat) under development by Sanofi-Genzyme[43]
* Bio-better ERT (CDX-6311) under pre-clinical development by the company Codexis[citation needed]
* A gene therapy (ST-920) under development by the company Sangamo.[44]
* A nucleoside-modified RNA treatment that has shown efficacy in a mouse model of Fabry disease and in cardiomyocytes derived from induced pluripotent stem cells from individuals with Fabry disease.[45]

### Organ-specific treatment

Pain associated with Fabry disease may be partially alleviated by enzyme replacement therapy in some patients, but pain management regimens may also include analgesics, anticonvulsants, and nonsteroidal anti-inflammatory drugs, though the latter are usually best avoided in kidney disease. The kidney failure seen in some of those with Fabry disease sometimes requires haemodialysis. The cardiac complications of Fabry disease include abnormal heart rhythms, which may require a pacemaker or implantable cardioverter-defibrillator, while the restrictive cardiomyopathy often seen may require diuretics.[20]

## Prognosis

Life expectancy with Fabry disease for males was 58.2 years, compared with 74.7 years in the general population, and for females 75.4 years compared with 80.0 years in the general population, according to registry data from 2001 to 2008. The most common cause of death was cardiovascular disease, and most of those had received kidney replacements.[46]

## Epidemiology

Fabry disease is panethnic, but due to its rarity, determining an accurate disease frequency is difficult.[15] Reported incidences, ranging from 1-5:10,000 in the general population, may largely underestimate the true prevalence.[15] Newborn screening initiatives have found an unexpectedly high prevalence of the disease, as high as one in about 3,100 newborns in Italy and around one in 1,500 newborn males in Taiwan.[15]

## Research

* Enzyme replacement therapy: Replacement of the missing enzyme to clear the lipids (GL-3) from the cells[17]
* Substrate synthesis inhibition, also called substrate reduction therapy: Inhibits the production of the lipid (GL-3) that accumulates in the cells[17]
* Chaperone therapy: Uses small-molecule drugs that bind to the defective enzyme and stabilize it to increase enzyme activity and increase cellular function[17]
* Gene editing: Technology that can potentially cut and fix a broken gene in a cell[17]
* Gene therapy: Genetically modifies the affected cells to produce the missing enzyme.[17]

### GT-GLA-S03

In March 2026, the FDA granted Orphan Drug Designation to GT-GLA-S03, an autologous cell therapy for the treatment of classic Fabry disease. Developed by Glafabra Therapeutics, the therapy utilizes a "redosable" hematopoietic stem cell approach to provide a continuous source of the alpha-galactosidase A enzyme. Long-term data from a five-year Canadian pilot study (NCT02800070) indicated that treated patients experienced a 48% median reduction in plasma lyso-Gb3 levels while maintaining stable renal and cardiac function. [47]

## History

Fabry disease was first described by dermatologist Johannes Fabry[2] and surgeon William Anderson[3] independently in 1898.[4] It was recognised to be due to abnormal storage of lipids in 1952. In the 1960s, the inheritance pattern was established as being X-linked, as well as the molecular defect responsible for causing the accumulation of glycolipids.[4]

Ken Hashimoto published his classic paper on his electron microscopic findings in Fabry disease in 1965.[48][49]

The first specific treatment for Fabry disease was approved in 2001.[20][50]

## Society and culture

* House ("Epic Fail", season six, episode three) centers on a patient with Fabry disease.[citation needed]
* Scrubs ("My Catalyst", season three, episode 12) features a Fabry disease diagnosis.[citation needed]
* Crossing Jordan ("There's No Place Like Home", season two, episode one) features a patient who died from Fabry disease.[citation needed]
* The Village (Korean drama): "Achiara's Secret"[51] features daughters of a serial rapist who find each other because they share Fabry disease.
* Doctor John (Korean drama): In episode two, a prisoner is diagnosed with Fabry disease.[citation needed]
* In Lincoln Rhyme: Hunt for the Bone Collector, a copycat of the titular Bone Collector has Fabry disease and takes Galafold, which allows the detectives to learn his identity.[citation needed]
* Partners for Justice 2  (Korean drama), features Doctor K, who had Fabry disease.[citation needed]
* Doc (Italian drama): Series two features an episode with a tennis player who is diagnosed with Fabry disease[citation needed]

## References

1. ↑ James, Berger & Elston 2006, p. 538
2. ↑ 2.0 2.1 "Ein Beitrag zur Kenntniss der Purpura haemorrhagica nodularis (Purpura papulosa haemorrhagica Hebrae)" (in de). Archiv für Dermatologie und Syphilis 43 (1): 187–200. December 1898. doi:10.1007/bf01986897. https://zenodo.org/record/2215206.
3. ↑ 3.0 3.1 "A Case of 'Angeio-Keratoma'". British Journal of Dermatology 10 (4): 113–117. April 1898. doi:10.1111/j.1365-2133.1898.tb16317.x. https://zenodo.org/record/1447597.
4. ↑ 4.0 4.1 4.2 "Fabry disease". Neurocutaneous Syndromes. Handbook of Clinical Neurology. 132. 2015. pp. 231–248. doi:10.1016/B978-0-444-62702-5.00017-2. ISBN 9780444627025.
5. ↑ "Fabry disease | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program" (in en). https://rarediseases.info.nih.gov/diseases/6400/fabry-disease.
6. ↑ "Nature and prevalence of pain in Fabry disease and its response to enzyme replacement therapy--a retrospective analysis from the Fabry Outcome Survey". The Clinical Journal of Pain 23 (6): 535–542. July 2007. doi:10.1097/AJP.0b013e318074c986. PMID 17575495.
7. ↑ 7.0 7.1 7.2 "Anderson-Fabry cardiomyopathy: prevalence, pathophysiology, diagnosis, and treatment". Heart Failure Reviews 20 (2): 179–191. March 2015. doi:10.1007/s10741-014-9452-9. PMID 25030479.
8. ↑ 8.0 8.1 8.2 "Anderson-Fabry disease in heart failure". Biophysical Reviews 10 (4): 1107–1119. August 2018. doi:10.1007/s12551-018-0432-5. PMID 29909504.
9. ↑ "Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part two". Pediatric Rheumatology Online Journal 15 (Suppl 2). 1 September 2017. doi:10.1186/s12969-017-0186-9.
10. ↑ 10.0 10.1 "Amiodarone-induced cornea verticillata". Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie 17 (3): 96–99. June 1982. PMID 7116220.
11. ↑ "Angiokeratoma corporis diffusum (Fabry disease)". Dermatology Online Journal 11 (4): 8. December 2005. doi:10.5070/D30TT696NJ. PMID 16403380.
12. ↑ "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports 9 (1). December 2019. doi:10.1038/s41598-019-54976-4. PMID 31819097. Bibcode: 2019NatSR...918577S.
13. ↑ James, Berger & Elston 2006, p. [page needed]
14. ↑ 14.0 14.1 14.2 "Fabry disease: focus on cardiac manifestations and molecular mechanisms". Herz 27 (7): 699–702. November 2002. doi:10.1007/s00059-002-2429-9. PMID 12439642.
15. ↑ 15.0 15.1 15.2 15.3 15.4 "Fabry disease". Orphanet Journal of Rare Diseases 5 (1): 30. November 2010. doi:10.1186/1750-1172-5-30. PMID 21092187.
16. ↑ "Misdiagnosis in Fabry disease". The Journal of Pediatrics 156 (5): 828–831. May 2010. doi:10.1016/j.jpeds.2010.02.012. PMID 20385321.
17. ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 "Diagnosis & Testing". https://www.fabrydisease.org/index.php/about-fabry-disease/fabry-disease-diagnosis-testing.
18. ↑ "Fabry disease in cardiology practice: Literature review and expert point of view". Archives of Cardiovascular Diseases 112 (4): 278–287. April 2019. doi:10.1016/j.acvd.2019.01.002. PMID 30826269.
19. ↑ "Diagnosis and treatment of the cardiovascular consequences of Fabry disease". QJM 112 (1): 3–9. January 2019. doi:10.1093/qjmed/hcy120. PMID 29878206.
20. ↑ 20.0 20.1 20.2 "European expert consensus statement on therapeutic goals in Fabry disease". Molecular Genetics and Metabolism 124 (3): 189–203. July 2018. doi:10.1016/j.ymgme.2018.06.004. PMID 30017653. https://discovery.ucl.ac.uk/id/eprint/10088871/.
21. ↑ "Agalsidase alfa: a review of its use in the management of Fabry disease". BioDrugs 26 (5): 335–354. October 2012. doi:10.2165/11209690-000000000-00000. PMID 22946754.
22. ↑ 22.0 22.1 "Replagal EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/replagal.
23. ↑ "With A Life-Saving Medicine In Short Supply, Patients Want Patent Broken". NPR.org. 4 August 2010. https://www.npr.org/blogs/health/2010/08/04/128973687/with-a-life-saving-medicine-in-short-supply-patients-want-patent-broken.
24. ↑ "Shire withdraws Replagal in USA as FDA wants more trials". PharmaTimes. 15 March 2012. http://www.pharmatimes.com/article/12-03-15/Shire_withdraws_Replagal_in_USA_as_FDA_wants_more_trials.aspx.
25. ↑ "Replagal FDA Approval Status". https://www.drugs.com/history/replagal.html.
26. ↑ 26.0 26.1 "Fabrazyme EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/fabrazyme.
27. ↑ "Drug Approval Package: Fabrazyme (agalsidase beta)". https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/103979_toc.cfm.
28. ↑ "Elfabrio EPAR". 8 May 2023. https://www.ema.europa.eu/en/medicines/human/EPAR/elfabrio. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
29. ↑ "Agalsidase alfa versus agalsidase beta for the treatment of Fabry disease: an international cohort study". Journal of Medical Genetics 55 (5): 351–358. May 2018. doi:10.1136/jmedgenet-2017-104863. PMID 29437868.
30. ↑ "Search for interventional trials with Replagal and Fabrazyme on clinicaltrials.gov". https://clinicaltrials.gov/ct2/results?type=Intr&intr=replagal+AND+fabrazyme.
31. ↑ Fabry disease: Management and outcome. 1. Oxford University Press. 2015. doi:10.1093/med/9780199592548.003.0338. ISBN 9780199592548. http://oxfordmedicine.com/view/10.1093/med/9780199592548.001.0001/med-9780199592548-chapter-338.
32. ↑ "Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study". Journal of Medical Genetics 54 (4): 288–296. April 2017. doi:10.1136/jmedgenet-2016-104178. PMID 27834756.
33. ↑ Clinical trial number NCT01218659 for "Study to Compare the Efficacy and Safety of Oral AT1001 and Enzyme Replacement Therapy in Patients With Fabry Disease" at ClinicalTrials.gov
34. ↑ "Migalastat Orphan Drug Designations and Approvals". https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=20031800.
35. ↑ "EU/3/06/368". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu306368.
36. ↑ "Amicus Therapeutics Announces European Commission Approval for Galafold (Migalastat) in Patients with Fabry Disease in European Union". GlobeNewswire. 31 May 2016. https://globenewswire.com/news-release/2016/05/31/844646/0/en/Amicus-Therapeutics-Announces-European-Commission-Approval-for-Galafold-Migalastat-in-Patients-with-Fabry-Disease-in-European-Union.html.
37. ↑ "Summary of Product Characteristics for Galafold". European Medicines Agency. June 2016. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004059/WC500208434.pdf.
38. ↑ "Galafold EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/galafold.
39. ↑ "Drug Approval Package: Galafold (migalastat)". https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208623Orig1s000TOC.cfm.
40. ↑ "Canada launches first gene therapy trial for Fabry disease". http://www.eurekalert.org/pub_releases/2013-01/ahs-clf012413.php.
41. ↑ "Open-Label, Study Of Efficacy and Safety Of AVR-RD-01 for Treatment -Naive Subjects With Classic Fabry Disease - Full Text View - ClinicalTrials.gov". https://clinicaltrials.gov/ct2/show/NCT03454893.
42. ↑ "UHN Start-up AVROBIO, Inc. Announces $60 Million Series B Financing to Advance Gene Therapy Pipeline for Lysosomal Storage Disorders and Apply Lentiviral Platform to Other Genetic Diseases | TDC". http://tdc.uhnresearch.ca/content/uhn-start-avrobio-inc-announces-60-million-series-b-financing-advance-gene-therapy-pipeline.
43. ↑ "Venglustat (Ibiglustat)". https://fabrydiseasenews.com/venglustat-ibiglustat/.
44. ↑ "Fabry Disease Treatment". https://www.fabrydisease.org/index.php/about-fabry-disease/fabry-disease-treatment.
45. ↑ "GLA-modified RNA treatment lowers GB3 levels in iPSC-derived cardiomyocytes from Fabry-affected individuals". American Journal of Human Genetics 110 (9): 1600–1605. September 2023. doi:10.1016/j.ajhg.2023.07.013. PMID 37607539.
46. ↑ "Life expectancy and cause of death in males and females with Fabry disease: findings from the Fabry Registry". Genetics in Medicine 11 (11): 790–796. November 2009. doi:10.1097/GIM.0b013e3181bb05bb. PMID 19745746.
47. ↑ "Glafabra Therapeutics Receives FDA Orphan Drug Designation for GT-GLA-S03, Advancing a Redosable Cell Therapy for Fabry Disease". Newsfile Corp. (Reportable, Inc.). March 12, 2026. https://www.newsfilecorp.com/release/288262/Glafabra-Therapeutics-Receives-FDA-Orphan-Drug-Designation-for-GTGLAS03-Advancing-a-Redosable-Cell-Therapy-for-Fabry-Disease.
48. ↑ John Thorne Crissey; Lawrence C. Parish; Karl Holubar (2013). Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 179. ISBN 978-1-84214-100-7. https://books.google.com/books?id=7ThZDwAAQBAJ&pg=PA179.
49. ↑ "History of lysosomal storage diseases: an overview". Fabry Disease: Perspectives from 5 Years of FOS. Oxford PharmaGenesis. 2006. ISBN 978-1903539033. https://www.ncbi.nlm.nih.gov/books/NBK11615/. Retrieved 10 August 2018.
50. ↑ "Shire Submits Biologics License Application (BLA) for Replagal with the U.S. Food and Drug Administration (FDA)". FierceBiotech. 22 December 2009. http://www.fiercebiotech.com/press-releases/shire-submits-biologics-license-application-bla-replagal-u-s-food-and-drug-administra.
51. ↑ "The Village: Achiara's Secret". http://tv.sbs.co.kr/village2015/.

## Further reading

* Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. 2006. ISBN 978-0-7216-2921-6.
* "Enzyme replacement therapy in Fabry disease: a randomized controlled trial". JAMA 285 (21): 2743–2749. June 2001. doi:10.1001/jama.285.21.2743. PMID 11386930.
* "Long-term safety and efficacy of enzyme replacement therapy for Fabry disease". American Journal of Human Genetics 75 (1): 65–74. July 2004. doi:10.1086/422366. PMID 15154115.

## External links

* Fabry Disease Information Page at NINDS
* Fabry disease at NLM Genetics Home Reference

Classification|

* ICD-10: E75.2 (ILDS E75.25)
* ICD-9-CM: 272.7
* OMIM: 301500
* MeSH: D000795
* DiseasesDB: 4638

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External resources|

* eMedicine: neuro/579 derm/707 ped/2888
* GeneReviews: Fabry disease

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