Fluspidine

Fluspidine is a fluorine-18 (18F) labeled radiotracer used in positron emission tomography (PET) scans to image σ1 (sigma-1) receptors in the brain and other tissues. Sigma-1 receptors are proteins involved in many neurological and psychiatric processes. They have been linked to pain modulation, psychosis, Alzheimer's disease, and depression.[1]

## Chemical properties

Fluspidine is a small organic compound with a spirocyclic structure. A 2-fluoroethyl group on the molecule carries the fluorine-18. The compound exists as two mirror image enantiomers, called (R)-fluspidine and (S)-fluspidine. These enantiomers have slightly different properties: (R)-fluspidine has about 4-fold higher affinity for the σ₁ receptor than (S)-fluspidine, but (S)-fluspidine is metabolically more stable in the body.[2]

## References

1. ↑ "[18FFluspidine-A PET Tracer for Imaging of σ1 Receptors in the Central Nervous System"]. Pharmaceuticals 17 (2): 166. January 2024. doi:10.3390/ph17020166. PMID 38399380.
2. ↑ "Distinctive in vivo kinetics of the new σ1 receptor ligands (R)-(+)- and (S)-(-)-18F-fluspidine in porcine brain". Journal of Nuclear Medicine 55 (10): 1730–1736. October 2014. doi:10.2967/jnumed.114.137562. PMID 25071097.

* v
* t
* e

Diagnostic radiopharmaceuticals (ATC: V09)

Central nervous system|

* 99mTc (Exametazime)
* 123I (Ioflupane
* Iofetamine
* Iomazenil)
* 18F (Florbetapir, Flutemetamol)

Skeletal system|

* 99mTc (Medronic acid)

Renal|

* 123I (Sodium iodohippurate)
* 64Cu (Cu-ETS2)

Gastrointestinal/Hepatic|

* 75Se (SeHCAT)

Respiratory system|

* 133Xe
* 81mKr
* 99mTc (99mTc-MAA)

Cardiovascular system|

* 99mTc (Sestamibi
* Tetrofosmin)
* 111In (Imciromab)
* 82Rb (Rubidium chloride)

Inflammation/infection|

* 99mTc (Exametazime
* Sulesomab
* Tilmanocept)
* 111In
* 67Ga

Tumor|

* 99mTc (Arcitumomab
* Votumumab
* Hynic-octreotide)
* 111In (Capromab pendetide
* Satumomab pendetide)
* 125I (Minretumomab)
* 123I / 131I (Iobenguane)
* 18F (Fluciclovine
* Fludeoxyglucose
* Fluoroethyltyrosine
* Sodium fluoride)

Adrenal cortex|

* 123I
* 125I / 131I (Iodocholesterol)

Radionuclides
(including tracers)|

| positron (PET list)|

* 11C ([11C]ME@HAPTHI
* 25B-NBOMe (Cimbi-36)
* Acetate
* Choline
* Carfentanil
* DASB
* DTBZ
* Flumazenil
* Methionine
* N-Methylspiperone
* Pittsburgh compound B
* Raclopride
* Verapamil)
* 13N (Ammonia)
* 15O (Water)
* 18F (Altanserin
* Desmethoxyfallypride
* FMISO
* Fallypride
* Florbetaben
* Florbetapir
* Flubatine
* Fluciclovine
* Fludeoxyglucose (18F) (FDG)-glucose analogue
* Flumazenil
* Fluorocholine
* Fluorodeoxysorbitol (FDS)
* Fluorodopa
* Fluorothymidine F-18
* Fluspidine
* Flutemetamol
* MPPF
* Mefway
* Nifene
* N-Methylspiperone
* FET
* Setoperone)
* 64Cu
* 68Ga
* 82Rb (Rubidium chloride)

|

gamma ray/photon (SPECT/scintigraphy)|

* 51Cr
* 57Co
* 67Ga
* 75Se
* 81mKr
* 99mTc
* 111In
* 123I
* 125I
* 131I
* 133Xe
* 153Sm
* 201Tl

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Fluspidine. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Medicine:Fluspidine&oldid=4028509"
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template