Haemophilus meningitis

Haemophilus meningitis is a form of bacterial meningitis caused by the Haemophilus influenzae bacteria. It is usually (but not always) associated with Haemophilus influenzae type b.[1] Meningitis involves the inflammation of the protective membranes that cover the brain and spinal cord. Haemophilus meningitis is characterized by symptoms including fever, nausea, sensitivity to light, headaches, stiff neck, anorexia, and seizures.[2][3] Haemophilus meningitis can be deadly, but antibiotics are effective in treating the infection, especially when cases are caught early enough that the inflammation has not done a great deal of damage.[2] Before the introduction of the Hib vaccine in 1985,[4] Haemophilus meningitis was the leading cause of bacterial meningitis in children under the age of five. However, since the creation of the Hib vaccine, only two in every 100,000 children contract this type of meningitis.[2] Five to ten percent of cases can be fatal,[5] although the average mortality rate in developing nations is seventeen percent,[3] mostly due to lack of access to vaccination as well as lack of access to medical care needed to combat the meningitis.

## Contents

* 1 Symptoms and signs
* 2 Risk factors
* 3 Diagnosis
* 4 Prevention
* 5 Treatment
* 6 Prognosis
* 7 References
* 8 External links

## Symptoms and signs

Possible symptoms of Haemophilus meningitis include:[2][3]

* Nausea or vomiting
* Fever
* Headache
* Sensitivity to light
* Seizures
* Anorexia
* change in mental status, such as irritability
* stiff neck

## Risk factors

While the Haemophilus influenzae bacteria are unable to survive in any environment outside of the human body, humans can carry the bacteria within their bodies without developing any symptoms of the disease. It spreads through the air when an individual carrying the bacteria coughs or sneezes.[4] The risk of developing Haemophilus meningitis is most directly related to an individual's vaccination history, as well as the vaccination history of the general public. Herd immunity, or the protection that unvaccinated individuals experience when the majority of others in their proximity are vaccinated, does help in the reduction of meningitis cases, but it does not guarantee protection from the disease.[3] Contact with other individuals with the disease also vastly increases the risk of infection. A child in the presence of family members sick with Haemophilus meningitis or carrying the bacteria is 585 times more likely to catch Haemophilus meningitis.[6] Additionally, siblings of individuals with the Haemophilus influenzae meningitis receive reduced benefits from certain types of immunization.[7] Similarly, children under two years of age have a greater risk of contracting the disease when attending day care, especially in their first month of attendance, due to the maintained contact with other children who might be asymptomatic carriers of the Hib bacteria.[3]

## Diagnosis

## Prevention

Before the widespread use of the Hib vaccine, Haemophilus meningitis accounted for 40%-60% of all meningitis cases in children under the age of fifteen, and 90% of all meningitis cases in children under the age of five.[3] Vaccination can reduce incidence.[8] Vaccination has reduced the occurrences of Haemophilus meningitis by 87-90% in countries with widespread access to the Hib vaccine.[3] Rates are still high in areas with limited levels of vaccination.[9] Less-developed countries as well as countries with medical infrastructure that has been damaged in any way, such as from warfare, do not have such widespread access to the vaccine and thus experience higher rates of meningitis cases. Multiple conjugate Hib vaccines are available for use, though, and are extremely effective when given to infants.[5] Additionally, the vaccine has only the side effects of reddened skin and swelling at the location of the injection.[5]

## Treatment

Because it is a bacterial disease, the primary method of treatment for Haemophilus meningitis is anti-bacterial therapy. Common antibiotics include ceftriaxone[2][3] or cefotaxime, both of which can combat the infection and thus reduce inflammation in the meninges, or the membranes that protect the brain and spinal cord. Anti-inflammatories such as corticosteroids, or steroids produced by the body to reduce inflammation, can also be used to fight the meningeal inflammation in an attempt to reduce risk of mortality and reduce the possibility of brain damage.[citation needed]

## Prognosis

Survivors of Haemophilus meningitis may experience permanent damage caused by inflammation around the brain, mostly involving neurological disorders. Long-term complications include brain damage, hearing loss, and mental disability.[5] Other possible long-term effects are reduced IQ, cerebral palsy, and the development of seizures.[10] Children that survive the disease are more often held back in school, and are more likely to require special education services.[10] Negative long-term effects are more likely in subjects whose treatments were delayed, as well as in subjects who were given antibiotics to which the bacteria was resistant.[3] Ten percent of survivors develop epilepsy, while close to twenty percent of survivors develop hearing loss ranging from mild loss to deafness. About 45% of survivors experience no negative long-term effects.[3]

## References

1. ↑ "Haemophilus influenzae type e meningitis and bacteremia in a healthy adult". Intern. Med. 46 (4): 195–8. 2007. doi:10.2169/internalmedicine.46.1807. PMID 17301516.
2. ↑ 2.0 2.1 2.2 2.3 2.4 "Meningitis - H. influenzae". U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000612.htm.
3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 Haran Chandrasekar, Pranatharthi; Cavaliere, Robert; Stanley Rust Jr, Robert; Swaminathan, Subramanian. "Haemophilus Meningitis". http://emedicine.medscape.com/article/1164916-overview#a0101.
4. ↑ 4.0 4.1 "Haemophilus influenzae type b (Hib)". The College of Physicians of Philadelphia. http://www.historyofvaccines.org/content/articles/haemophilus-influenzae-type-b-hib.
5. ↑ 5.0 5.1 5.2 5.3 "Haemophilus influenzae type b (Hib)". World Health Organization. https://www.who.int/immunization/topics/hib/en/index1.html.
6. ↑ "Haemophilus influenzae meningitis. A national study of secondary spread in household contacts". N. Engl. J. Med. 301 (3): 122–6. July 1979. doi:10.1056/NEJM197907193010302. PMID 313003.
7. ↑ "Siblings of patients with Haemophilus meningitis have impaired anticapsular antibody responses to Haemophilus vaccine". J. Pediatr. 103 (2): 185–91. August 1983. doi:10.1016/s0022-3476(83)80342-4. PMID 6603504.
8. ↑ "Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil". Cad Saude Publica 23 (7): 1689–95. July 2007. doi:10.1590/s0102-311x2007000700021. PMID 17572819.
9. ↑ "Incidence of Haemophilus influenzae type b meningitis in India". Indian J. Med. Res. 128 (1): 57–64. July 2008. PMID 18820360.
10. ↑ 10.0 10.1 "Long-term outcome of Haemophilus influenzae meningitis in Navajo Indian children". Arch Pediatr Adolesc Med 149 (9): 1001–8. September 1995. doi:10.1001/archpedi.1995.02170220067009. PMID 7655584.

## External links

Classification|

* ICD-10: G00.0
* ICD-9-CM: 320.0
* MeSH: D008583

|

* v
* t
* e

* Infectious diseases
* Bacterial disease: ProteobacterialG−]]
* primarily A00–A79, 001–041, 080–109

| Rickettsiales|

| Rickettsiaceae/
(Rickettsioses)|

| Typhus|

* Rickettsia typhi
* Murine typhus
* Rickettsia prowazekii
* Epidemic typhus, Brill–Zinsser disease, Flying squirrel typhus

|

Spotted
fever|

| Tick-borne|

* Rickettsia rickettsii
* Rocky Mountain spotted fever
* Rickettsia conorii
* Boutonneuse fever
* Rickettsia japonica
* Japanese spotted fever
* Rickettsia sibirica
* North Asian tick typhus
* Rickettsia australis
* Queensland tick typhus
* Rickettsia honei
* Flinders Island spotted fever
* Rickettsia africae
* African tick bite fever
* Rickettsia parkeri
* American tick bite fever
* Rickettsia aeschlimannii
* Rickettsia aeschlimannii infection

|

Mite-borne|

* Rickettsia akari
* Rickettsialpox
* Orientia tsutsugamushi
* Scrub typhus

Flea-borne|

* Rickettsia felis
* Flea-borne spotted fever

Anaplasmataceae|

* Ehrlichiosis: Anaplasma phagocytophilum
* Human granulocytic anaplasmosis, Anaplasmosis
* Ehrlichia chaffeensis
* Human monocytotropic ehrlichiosis
* Ehrlichia ewingii
* Ehrlichiosis ewingii infection

Rhizobiales|

| Brucellaceae|

* Brucella abortus
* Brucellosis

|

Bartonellaceae|

* Bartonellosis: Bartonella henselae
* Cat-scratch disease
* Bartonella quintana
* Trench fever
* Either B. henselae or B. quintana
* Bacillary angiomatosis
* Bartonella bacilliformis
* Carrion's disease, Verruga peruana

| Neisseriales|

| M+|

* Neisseria meningitidis/meningococcus
* Meningococcal disease, Waterhouse–Friderichsen syndrome]], Meningococcal septicaemia

|

M−|

* Neisseria gonorrhoeae/gonococcus
* Gonorrhea

ungrouped:|

* Eikenella corrodens/Kingella kingae
* HACEK
* Chromobacterium violaceum
* Chromobacteriosis infection

Burkholderiales|

* Burkholderia pseudomallei
* Melioidosis
* Burkholderia mallei
* Glanders
* Burkholderia cepacia complex
* Bordetella pertussis/Bordetella parapertussis
* Pertussis

| Enterobacteriales
(OX−)|

| Lac+|

* Klebsiella pneumoniae
* Rhinoscleroma, Pneumonia
* Klebsiella granulomatis
* Granuloma inguinale
* Klebsiella oxytoca

* Escherichia coli: Enterotoxigenic
* Enteroinvasive
* Enterohemorrhagic
* O157:H7
* O104:H4
* Hemolytic-uremic syndrome

* Enterobacter aerogenes/Enterobacter cloacae

|

Slow/weak|

* Serratia marcescens
* Serratia infection
* Citrobacter koseri/Citrobacter freundii

Lac−|

| H2S+|

* Salmonella enterica
* Typhoid fever, Paratyphoid fever, Salmonellosis

|

H2S−|

* Shigella dysenteriae/sonnei/flexneri]]/boydii
* Shigellosis, Bacillary dysentery
* Proteus mirabilis/Proteus vulgaris
* Yersinia pestis
* Plague/Bubonic plague
* Yersinia enterocolitica
* Yersiniosis
* Yersinia pseudotuberculosis
* Far East scarlet-like fever

Pasteurellales|

| Haemophilus:|

* H. influenzae
* Haemophilus meningitis
* Brazilian purpuric fever
* H. ducreyi
* Chancroid
* H. parainfluenzae
* HACEK

|

Pasteurella multocida|

* Pasteurellosis
* Actinobacillus
* Actinobacillosis

Aggregatibacter actinomycetemcomitans|

* HACEK

Legionellales|

* Legionella pneumophila/Legionella longbeachae
* Legionnaires' disease
* Coxiella burnetii
* Q fever

Thiotrichales|

* Francisella tularensis
* Tularemia

Vibrionaceae|

* Vibrio cholerae
* Cholera
* Vibrio vulnificus
* Vibrio parahaemolyticus
* Vibrio alginolyticus
* Plesiomonas shigelloides

Pseudomonadales|

* Pseudomonas aeruginosa
* Pseudomonas infection
* Moraxella catarrhalis
* Acinetobacter baumannii

Xanthomonadaceae|

* Stenotrophomonas maltophilia

Cardiobacteriaceae|

* Cardiobacterium hominis
* HACEK

Aeromonadales|

* Aeromonas hydrophila/Aeromonas veronii
* Aeromonas infection

| Campylobacterales|

* Campylobacter jejuni
* Campylobacteriosis, Guillain–Barré syndrome]]
* Helicobacter pylori
* Peptic ulcer, MALT lymphoma, Gastric cancer
* Helicobacter cinaedi
* Helicobacter cellulitis

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