Homing (hematopoietic)

Short description: Migration of cells toward their organ of origin

Homing is the phenomenon whereby cells migrate to the organ of their origin. By homing, transplanted hematopoietic cells are able to travel to and engraft (establish residence) in the bone marrow. Various chemokines[1] and receptors[2] are involved in the homing of hematopoietic stem cells.[3]

## Sites

* Bone marrow
* Lymph nodes[4]
* Skin

## References

1. ↑ Cyster, JG; Ngo, VN; Ekland, EH; Gunn, MD; Sedgwick, JD; Ansel, KM (1999). Chemokines and B-cell homing to follicles. Current Topics in Microbiology and Immunology. 246. pp. 87–92; discussion 93. doi:10.1007/978-3-642-60162-0_11. ISBN 978-3-642-64283-8.
2. ↑ Lopez-Giral, S.; Quintana, NE; Cabrerizo, M; Alfonso-Pérez, M; Sala-Valdés, M; De Soria, VG; Fernández-Rañada, JM; Fernández-Ruiz, E et al. (23 April 2004). "Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination". Journal of Leukocyte Biology 76 (2): 462–471. doi:10.1189/jlb.1203652. PMID 15155773. http://www.jleukbio.org/content/76/2/462.abstract. Retrieved 23 December 2012.
3. ↑ Yusuf, Rushdia Z.; Scadden, David T. (17 March 2009). "Homing of Hematopoietic Cells to the Bone Marrow". Journal of Visualized Experiments (25): e1104. doi:10.3791/1104. PMID 19295497. PMC 2762899. http://www.jove.com/video/1104/homing-of-hematopoietic-cells-to-the-bone-marrow. Retrieved 23 December 2012.
4. ↑ von Andrian, Ulrich H.; Mempel, Thorsten R. (1 November 2003). "Homing and cellular traffic in lymph nodes". Nature Reviews Immunology 3 (11): 867–878. doi:10.1038/nri1222. PMID 14668803. http://labs.idi.harvard.edu/vonandrian/Pages/mempelvonandriannri.pdf. Retrieved 23 December 2012.

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