Hypothalamic obesity

Hypothalamic obesity (abbreviated HO or HyOb) is a rare condition that can be congenital or acquired. Congenital causes include Prader-Willi syndrome and mutations of LEP (leptin gene), LEPR, POMC, MC4R, and CART. It can also result from injuries to the hypothalamus either from trauma, therapeutic radiation, brain surgery, and especially craniopharyngioma and its treatments. Possible treatments include bariatric surgery and melanocortin 4 receptor agonists such as setmelanotide.[1][2][3][4]

## References

1. ↑ Dimitri, Paul (6 April 2022). "Treatment of Acquired Hypothalamic Obesity: Now and the Future". Frontiers in Endocrinology 13: 846880. doi:10.3389/fendo.2022.846880. ISSN 1664-2392. PMID 35464063.
2. ↑ Bereket, A.; Kiess, W.; Lustig, R. H.; Muller, H. L.; Goldstone, A. P.; Weiss, R.; Yavuz, Y.; Hochberg, Z. (September 2012). "Hypothalamic obesity in children". Obesity Reviews 13 (9): 780–798. doi:10.1111/j.1467-789X.2012.01004.x. PMID 22577758.
3. ↑ Abuzzahab, M. Jennifer; Roth, Christian L.; Shoemaker, Ashley H. (2019). "Hypothalamic Obesity: Prologue and Promise". Hormone Research in Paediatrics 91 (2): 128–136. doi:10.1159/000496564. PMID 30884480.
4. ↑ Kim, Ja Hye; Choi, Jin-Ho (December 2013). "Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents". Annals of Pediatric Endocrinology & Metabolism 18 (4): 161–167. doi:10.6065/apem.2013.18.4.161. ISSN 2287-1012. PMID 24904871.

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