Interstitial nephritis

Acute interstitial nephritis on light microscopy

Interstitial nephritis, also known as tubulointerstitial nephritis, is inflammation of the area of the kidney known as the renal interstitium, which consists of a collection of cells, extracellular matrix, and fluid surrounding the renal tubules. It is also known as intestinal nephritis because the clinical picture may include mesenteric lymphadenitis in some cases of acute pyelonephritis (mostly due to use of NSAIDs). More specifically, in case of recurrent urinary tract infection, secondary infection can spread to adjacent intestine.[1] In addition to providing a scaffolding support for the tubular architecture, the interstitium has been shown to participate in the fluid and electrolyte exchange as well as endocrine functions of the kidney.[1]

There are a variety of known factors that can provoke the inflammatory process within the renal interstitium, including pharmacologic, environmental, infectious and systemic disease contributors. The spectrum of disease presentation can range from an acute process to a chronic condition with progressive tubular cell damage and renal dysfunction.

## Contents

* 1 Signs and symptoms
* 2 Causes
* 2.1 Drugs
* 3 Diagnosis
* 3.1 Blood tests
* 3.2 Urinary findings
* 3.3 Pathology
* 3.4 Gallium scan
* 3.5 Novel biomarkers
* 4 Treatment
* 5 Prognosis
* 6 Epidemiology
* 7 References
* 8 External links

## Signs and symptoms

Interstitial nephritis may present with a variety of signs and symptoms, many of these nonspecific. Fever is the most common, occurring in 30-50% of patients, particularly those with drug-induced interstitial nephritis.[2] Other general symptoms that occur with variable frequency include nausea, vomiting, fatigue, lack of appetite, and weight loss. More specific symptoms, such as flank pain, pain with urination, and visible blood in the urine, as well as signs like hypertension can be helpful in increasing suspicion for the diagnosis.[3] The "classic" triad of symptoms reported in early documented cases consisted of rash, joint pain, and increased eosinophils in the blood; however, more recent epidemiology suggests that this grouping of symptoms only occurs in a small minority (5-10%) of patients.[4] With modern drugs causing between 70 and 90% of current cases,[5][6] the possibility of a change in presentation exists.

## Causes

Common causes include infection, or reaction to medication such as an analgesic, anti-inflammatory,[7] or antibiotics such as methicillin (meticillin). Reaction to medications causes 71%[5] to 92%[6] of cases.

### Drugs

Examples of Drugs Associated With Interstitial Nephritis[2][8] Class  | Examples

|

Antibiotic  | β-lactams (e.g. penicillins, cephalosporins), sulfonamides (e.g. trimethoprim-sulfamethoxazole), fluoroquinolones (e.g. ciprofloxacin), macrolides (e.g. erythromycin), anti-tuberculins (e.g. rifampin, ethambutol), chloramphenicol
Anti-inflammatory  | Nonsteroidal antiinflammatory drugs (e.g. ibuprofen, naproxen), selective COX-2 inhibitors (e.g. celecoxib)
Antiviral  | Acyclovir, atazanavir, abacavir, indinavir
Analgesic  | Aspirin, acetaminophen
Gastrointestinal  | Proton pump inhibitors (e.g. omeprazole, lansoprazole), H2-receptor blockers (e.g. cimetidine), 5-aminosalicylates (e.g. mesalamine)
Antiseizure  | Phenytoin, carbamazepine, phenobarbital
Diuretic  | Hydrochlorothiazide, furosemide, triamterene, chlorthalidone
Chemotherapy  | Tyrosine kinase inhibitors (e.g. sunitinib), checkpoint inhibitors (e.g. ipilimumab, nivolumab, pembrolizumab, atezolizumab)
Contrast agent  | Gadolininum based contrast agent[9][10]
Other  | Allopurinol, Chinese herbs

This disease is also caused by other diseases and toxins that damage the kidney. Both acute and chronic tubulointerstitial nephritis can be caused by a bacterial infection in the kidneys known as pyelonephritis, but the most common cause is by an adverse reaction to a medication. The medications that are known to cause this sort of reaction are β-lactam antibiotics such as penicillin[11] and cephalexin, and nonsteroidal anti-inflammatory drugs (aspirin less frequently than others), as well as proton-pump inhibitors, rifampicin, sulfa medications, fluoroquinolones, diuretics, allopurinol, mesalamine, and phenytoin. The time between exposure to the drug and the development of acute tubulointerstitial nephritis can be anywhere from 5 days to 5 months (fenoprofen-induced).[citation needed]

## Diagnosis

The condition can appear without symptoms. When present they may appear widely varied and can occur rapidly or gradually.[5][12][13][14][15]

When caused by an allergic reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),[5] rash (15% of patients),[5] and enlarged kidneys. Some people experience dysuria, and lower back pain.

In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include a high concentration of potassium in the blood, metabolic acidosis, and kidney failure.[citation needed]

### Blood tests

About 23% of patients have a high level of eosinophils in the blood.[5]

### Urinary findings

Urinary findings include:

* Eosinophiluria: Original studies with Methicillin-induced AIN showed sensitivity of 67% and specificity of 83%.[12][16] The sensitivity is higher in patients with interstitial nephritis induced by methicillin or when the Hansel's stain is used. However, a 2013 study showed that the sensitivity and specificity of urine eosinophil testing are 35.6% and 68% respectively.[17][18]
* Isosthenuria[19]
* Blood in the urine and occasional RBC casts[20]
* Sterile pyuria: white blood cells and no bacteria. About 50% of patients with AIN have pyuria.[21]
* Nephrotic-range amount of protein in the urine may be seen with NSAID-associated AIN. Low grade proteinuria may be seen in a majority of other causes of AIN.[21]
* White blood cell (WBC) casts: Fewer than one in five patients with AIN have WBC casts in urine.[22]

### Pathology

While non-invasive patient evaluation (physical examination, blood and urine testing, imaging studies) can be suggestive, the only way to definitively diagnosis interstitial nephritis is with a tissue diagnosis obtained by kidney biopsy. Pathologic examination will reveal the presence of interstitial edema and inflammatory infiltration with various white blood cells, including neutrophils, eosinophils, and lymphocytes. Generally, blood vessels and glomeruli are not affected. Electron microscopy shows mitochondrial damage in the tubular epithelial cells, vacuoles in the cytoplasm, and enlarged endoplasmic reticulum.[23]

### Gallium scan

The sensitivity of an abnormal gallium scan has been reported to range from 60%[24] to 100%.[25] A study of Gallium scan in 76 patients [23 with AIN, 8 with biopsy-proven AIN] showed an AUC of 0.75.[26]

### Novel biomarkers

Given the challenges with clinical diagnosis of AIN due to lack of clinical features and lack of accuracy of existing tests, there has been significant interest in identifying non-invasive biomarkers for this disease. One study showed that monocyte chemotactic protein-1 (chemokine CCL-2) and neutrophil gelatinase associated lipocalin (NGAL) were higher in patients with AIN than in controls (in this case healthy participants).[27] A more recent study, showed that urine cytokines interleukin-9 and tumor necrosis factor-α were higher in patients with AIN than in controls without AIN who underwent a biopsy for evaluation of acute kidney injury and showed an AUC of 0.79.[28] This study also showed that the biomarkers had higher AUC than the clinician's pre-biopsy impression of AIN and, when added to a model of clinical variables, showed an AUC of 0.84. In a subsequent study, interleukin-9 was also shown to identify patients most likely to respond to corticosteroid therapy.[29]

## Treatment

Treatment consists of addressing the cause, such as by removing an offending drug. There is no clear evidence that corticosteroids help.[6] Nutrition therapy consists of adequate fluid intake, which can require several liters of extra fluid.[30]

## Prognosis

The kidneys are the only body system that are directly affected by tubulointerstitial nephritis. Kidney function is usually reduced; the kidneys can be just slightly dysfunctional, or fail completely.[citation needed]

In chronic tubulointerstitial nephritis, the most serious long-term effect is kidney failure. When the proximal tubule is injured, sodium, potassium, bicarbonate, uric acid, and phosphate reabsorption may be reduced or changed, resulting in low bicarbonate, known as metabolic acidosis, low potassium, low uric acid known as hypouricemia, and low phosphate known as hypophosphatemia. Damage to the distal tubule may cause loss of urine-concentrating ability and polyuria.[citation needed]

In most cases of acute tubulointerstitial nephritis, the function of the kidneys will return after the harmful drug is discontinued, or when the underlying disease is cured by treatment.

If the illness is caused by an allergic reaction, a corticosteroid may speed the recovery kidney function; however, this is often not the case.

Chronic tubulointerstitial nephritis has no cure. Some patients may require dialysis. Eventually, a kidney transplant may be needed.[citation needed]

## Epidemiology

Interstitial nephritis is uncommon (<1% incidence) in patients without any symptoms but occurs in about 10-15% of hospitalized patients with acute kidney injury of unknown cause.[2] While it can occur in patients of all ages, it is more common in elderly patients, perhaps due to increased exposure to drugs and other triggering causes.[2]

## References

1. ↑ 1.0 1.1 Zeisberg, Michael; Kalluri, Reghu (October 2015). "Physiology of the Renal Interstitium". Clinical Journal of the American Society of Nephrology 10 (10): 1831–1840. doi:10.2215/CJN.00640114. PMID 25813241.
2. ↑ 2.0 2.1 2.2 2.3 Brewster, Ursula C.; Rastegar, Asghar (2014), "Acute Interstitial Nephritis", National Kidney Foundation Primer on Kidney Diseases (Elsevier): pp. 312–317, doi:10.1016/b978-1-4557-4617-0.00035-2, ISBN 9781455746170
3. ↑ Meyers, Catherine M. (2014), "Chronic Tubulointerstitial Disease", National Kidney Foundation Primer on Kidney Diseases, Elsevier, pp. 390–396, doi:10.1016/b978-1-4557-4617-0.00045-5, ISBN 9781455746170
4. ↑ Brewster, Ursula C.; Rastegar, Asghar (2014), "Acute Interstitial Nephritis", National Kidney Foundation Primer on Kidney Diseases (Elsevier): pp. 312–317, doi:10.1016/b978-1-4557-4617-0.00035-2, ISBN 9781455746170
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "The changing profile of acute tubulointerstitial nephritis". Nephrol Dial Transplant 19 (1): 8–11. 2004. doi:10.1093/ndt/gfg464. PMID 14671029.
6. ↑ 6.0 6.1 6.2 "Acute interstitial nephritis: clinical features and response to corticosteroid therapy". Nephrol Dial Transplant 19 (11): 2778–83. 2004. doi:10.1093/ndt/gfh485. PMID 15340098.
7. ↑ [1] National Kidney Organization. “Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.”
8. ↑ Praga, Manuel; Appel, Gerald (2018-11-01). "Clinical manifestations and diagnosis of acute interstitial nephritis". https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-acute-interstitial-nephritis.
9. ↑ Elmholdt, T. R.; Olesen, A. B.; Jørgensen, B.; Kvist, S.; Skov, L.; Thomsen, H. S.; Marckmann, P.; Pedersen, M. (2013). "Nephrogenic Systemic Fibrosis in Denmark– A Nationwide Investigation" (in en). PLOS ONE 8 (12): e82037. doi:10.1371/journal.pone.0082037. PMID 24349178. Bibcode: 2013PLoSO...882037E.
10. ↑ Akgun, Hulya; Gonlusen, Gulfiliz; Cartwright, Jr, Joiner; Suki, Wadi N. (2006-09-01). "Are Gadolinium-Based Contrast Media Nephrotoxic?: A Renal Biopsy Study". Archives of Pathology & Laboratory Medicine 130 (9): 1354–1357. doi:10.5858/2006-130-1354-AGCMNA. ISSN 0003-9985. PMID 16948524. https://doi.org/10.5858/2006-130-1354-AGCMNA. Retrieved 2022-07-25.
11. ↑ Ohlsson, Arne; Shah, Vibhuti S; Ohlsson, Arne (2014). "Intrapartum antibiotics for known maternal Group B streptococcal colonization". Cochrane Database of Systematic Reviews (6): CD007467. doi:10.1002/14651858.CD007467.pub4. PMID 24915629.
12. ↑ 12.0 12.1 Rossert J (2001). "Drug-induced acute interstitial nephritis". Kidney Int 60 (2): 804–17. doi:10.1046/j.1523-1755.2001.060002804.x. PMID 11473672.
13. ↑ "Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy". Q J Med 52 (206): 194–211. 1983. PMID 6604293.
14. ↑ Handa S (1986). "Drug-induced acute interstitial nephritis: report of 10 cases". CMAJ 135 (11): 1278–81. PMID 3779558.
15. ↑ "Acute interstitial nephritis: a clinical and morphological study in 27 patients". Nephrol Dial Transplant 5 (2): 94–9. 1990. doi:10.1093/ndt/5.2.94. PMID 2113219.
16. ↑ "The outcome of acute interstitial nephritis risk factors for the transition from acute to chronic interstitial nephritis". Clin Nephrol 54 (3): 179–90. 2000. PMID 11020015.
17. ↑ Muriithi, A. K.; Nasr, S. H.; Leung, N. (2013). "Utility of urine eosinophils in the diagnosis of acute interstitial nephritis". Clinical Journal of the American Society of Nephrology 8 (11): 1857–62. doi:10.2215/CJN.01330213. PMID 24052222.
18. ↑ Perazella, M. A.; Bomback, A. S. (2013). "Urinary eosinophils in AIN: Farewell to an old biomarker?". Clinical Journal of the American Society of Nephrology 8 (11): 1841–3. doi:10.2215/CJN.08620813. PMID 24052220.
19. ↑ "Urinary indices in acute interstitial nephritis". Clin Nephrol 26 (3): 131–3. 1986. PMID 3769228.
20. ↑ Fogazzi, G. B.; Ferrari, B.; Garigali, G.; Simonini, P.; Consonni, D. (2012). "Urinary sediment findings in acute interstitial nephritis". American Journal of Kidney Diseases 60 (2): 330–2. doi:10.1053/j.ajkd.2012.05.002. PMID 22677261.
21. ↑ 21.0 21.1 Frank B. Cortazar, Zoe A. Kibbelaar, Ilya G. Glezerman, Ala Abudayyeh, Omar Mamlouk, Shveta S. Motwani, Naoka Murakami, Sandra M. Herrmann, Sandhya Manohar, Anushree C. Shirali, Abhijat Kitchlu, Shayan Shirazian, Amer Assal, Anitha Vijayan, Amanda DeMauro Renaghan, David I. Ortiz-Melo, Sunil Rangarajan, A. Bilal Malik, Jonathan J. Hogan, Alex R. Dinh, Daniel Sanghoon Shin, Kristen A. Marrone, Zain Mithani, Douglas B. Johnson, Afrooz Hosseini, Deekchha Uprety, Shreyak Sharma, Shruti Gupta, Kerry L. Reynolds, Meghan E. Sise, David E. Leaf JASN Feb 2020, 31 (2) 435-446; DOI: 10.1681/ASN.2019070676
22. ↑ Urinary Sediment Findings in Acute Interstitial Nephritis Fogazzi, Giovanni B. et al. American Journal of Kidney Diseases, Volume 60, Issue 2, 330 - 332
23. ↑ Alon, Uri S. (2015-11-12), "Pediatric Tubulointerstitial Nephritis", Pediatric Nephrology, Springer Berlin Heidelberg, pp. 1407–1428, doi:10.1007/978-3-662-43596-0_40, ISBN 9783662435953
24. ↑ "Failure of Gallium-67 scintigraphy to identify reliably noninfectious interstitial nephritis: concise communication". J Nucl Med 24 (7): 568–70. 1983. PMID 6864309.
25. ↑ "Gallium67 scintigraphy in the diagnosis of acute renal disease". Clin Nephrol 24 (2): 84–7. 1985. PMID 3862487.
26. ↑ Graham F, Lord M, Froment D, Cardinal H, Bollée G. The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis. Clin Kidney J. 2016;9(1):76-81. doi:10.1093/ckj/sfv129
27. ↑ Wu Y, Yang L, Su T, Wang C, Liu G, Li XM. Pathological significance of a panel of urinary biomarkers in patients with drug-induced tubulointerstitial nephritis. Clin J Am Soc Nephrol. 2010;5(11):1954-1959. doi:10.2215/CJN.02370310
28. ↑ Moledina DG, Wilson FP, Pober JS, et al. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight. 2019;4(10):e127456. Published 2019 May 16. doi:10.1172/jci.insight.127456
29. ↑ Dennis G Moledina, F Perry Wilson, Lidiya Kukova, Wassim Obeid, Randy Luciano, Michael Kuperman, Gilbert W Moeckel, Michael Kashgarian, Mark A Perazella, Lloyd G Cantley, Chirag R Parikh, Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis, Nephrology Dialysis Transplantation, 2020;, gfaa169, https://doi.org/10.1093/ndt/gfaa169
30. ↑ Alexopolos Y, ed (2003). "39". Krause's Food, Nutrition, & Diet Therapy (11th ed.). Philadelphia Pennsylvania: Saunders. p. 968. ISBN 978-0-7216-9784-0. https://archive.org/details/krausesfoodnutri00maha.

## External links

* Merck Manual

Classification|

* ICD-10: N10-N12
* ICD-9-CM: 580.89, 581.89, 582.89, 583.89
* MeSH: D009395
* DiseasesDB: 6854

|

External resources|

* MedlinePlus: 000464
* eMedicine: med/1596

* v
* t
* e

Diseases of the urinary system (N00–N39, 580–599)

Kidney disease|

| Glomerules|

| Primarily
nephrotic|

| Non-proliferative|

* Minimal change
* Focal segmental
* Membranous

|

Proliferative|

* Mesangial proliferative
* Endocapillary proliferative
* Membranoproliferative/mesangiocapillary

By condition|

* Diabetic
* Amyloidosis

Primarily
nephritic,
RPG|

| Type I RPG/Type II hypersensitivity|

* Goodpasture's syndrome

|

Type II RPG/Type III hypersensitivity|

* Post-streptococcal
* Lupus
* DPGN
* IgA/Berger's

Type III RPG/Pauci-immune|

* Granulomatosis with polyangiitis
* Microscopic polyangiitis
* Eosinophilic granulomatosis with polyangiitis

General|

* glomerulonephritis
* glomerulonephrosis

Tubules|

* Renal tubular acidosis
* proximal
* distal
* Acute tubular necrosis
* Genetic
* Fanconi syndrome
* Bartter syndrome
* Gitelman syndrome
* Liddle's syndrome

Interstitium|

* Interstitial nephritis
* Pyelonephritis
* Balkan endemic nephropathy

General|

| General syndromes|

* Nephritis
* Nephrosis
* Renal failure
* Acute renal failure
* Chronic kidney disease
* Uremic pericarditis
* Uremia
* Diabetes insipidus
* Nephrogenic
* Renal papilla
* Renal papillary necrosis
* Major calyx/pelvis
* Hydronephrosis
* Pyonephrosis
* Reflux nephropathy

|

Vascular|

* Renal artery stenosis
* Renal ischemia
* Hypertensive nephropathy
* Renovascular hypertension
* Renal cortical necrosis

Other|

* Analgesic nephropathy
* Renal osteodystrophy
* Nephroptosis
* Abderhalden–Kaufmann–Lignac syndrome

Urinary tract|

| Ureter|

* Ureteritis
* Ureterocele
* Megaureter

|

Bladder|

* Cystitis
* Interstitial cystitis
* Hunner's ulcer
* Trigonitis
* Hemorrhagic cystitis
* Neurogenic bladder dysfunction
* Bladder sphincter dyssynergia
* Vesicointestinal fistula
* Vesicoureteral reflux

Urethra|

* Urethritis
* Non-gonococcal urethritis
* Urethral syndrome
* Urethral stricture/Meatal stenosis
* Urethral caruncle

Any/all|

* Obstructive uropathy
* Urinary tract infection
* Retroperitoneal fibrosis
* Urolithiasis
* Bladder stone
* Kidney stone
* Renal colic
* Malakoplakia
* Urinary incontinence
* Stress
* Urge
* Overflow

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