List of vaccine ingredients

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This list of vaccine ingredients indicates the culture media used in the production of common vaccines and the excipients they contain, as published by the United States Centers for Disease Control and Prevention and Food and Drug Administration. Vaccine ingredients and production in other nations are substantially the same. Also listed are substances used in the manufacturing process.[1]

To read the prescribing information for each individual vaccine, see List of Licensed Vaccines

Vaccine  | Culture media  | Excipients

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Adenovirus vaccine | Dulbecco's Modified Eagle Medium, human diploid fibroblast cell culture (WI-38)  | Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminum lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium, potassium phosphate, sodium bicarbonate, sucrose
Anthrax vaccine (BioThrax)  | Puziss–Wright medium 1095, synthetic or semisynthetic  | Aluminum hydroxide, amino acids, benzethonium chloride, formaldehyde, inorganic salts and sugars, vitamins
BCG (Bacillus Calmette-Guérin) (Tice BCG)  | Synthetic or semisynthetic  | Asparagine, citric acid, lactose, glycerin, iron ammonium citrate, magnesium sulfate, potassium phosphate
DTaP (Daptacel)  | Cohen–Wheeler or Stainer–Scholte media, synthetic or semisynthetic  | Aluminum phosphate, formaldehyde, Glutaraldehyde, 2-phenoxyethanol
DTaP (Infanrix)  | Cohen–Wheeler or Stainer–Scholte media, Lathan medium derived from bovine casein, Linggoud–Fenton medium derived from bovine extract, synthetic or semisynthetic  | Aluminum hydroxide, bovine extract, formaldehyde, glutaraldhyde, polysorbate 80
DTaP (Tripedia)  | Cohen–Wheeler or Stainer–Scholte media, synthetic or semisynthetic  | Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde, gelatin, peptone, polysorbate 80, sodium phosphate, thimerosal[2]
DTaP-Hib (TriHIBit)  | Synthetic or semisynthetic  | Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde or formalin, gelatin, polysorbate 80, sucrose, thimerosal[2]
DTaP-IPV (Kinrix)  | Vero (monkey kidney) cell culture, synthetic or semisynthetic  | Aluminum hydroxide, calf serum, formaldehyde, glutaraldehyde, lactalbumin hydrolysate, neomycin sulfate, polymyxin B, polysorbate 80
DTaP-HepB-IPV (Pediarix)  | Bovine protein, Lathan medium derived from bovine casein, Linggoud–Fenton medium derived from bovine extract, Vero (monkey kidney) cell culture, synthetic or semisynthetic  | Aluminum hydroxide, aluminum phosphate, calf serum, lactalbumin hydrolysate, formaldehyde, glutaraldhyde, neomycin sulfate, polymyxin B, polysorbate 80, yeast protein
DTaP-IPV-Hib (Pentacel)  | Synthetic or semisynthetic  | Aluminum phosphate, bovine serum albumin, formaldehyde, glutaraldehyde, MRC-5 cellular protein, neomycin, polymyxin B sulfate, polysorbate 80, 2-phenoxyethanol
DT vaccine (diphtheria vaccine plus tetanus vaccine) (Sanofi)  | Synthetic or semisynthetic  | Aluminum potassium sulfate, bovine extract, formaldehyde, thimerosal
DT vaccine (Massachusetts)  | Synthetic or semisynthetic  | Aluminum hydroxide, formaldehyde or formalin
Hib vaccine (ActHIB)  | Synthetic or semisynthetic  | Ammonium sulfate, formaldehyde, sucrose[3]
Hib vaccine (PedvaxHib)  | Synthetic or semisynthetic  | Aluminum hydroxyphosphate sulfate[4]
Hib vaccine (Hiberix)  | Semisynthetic  | Formaldehyde, lactose[5]
Hib-HepB (Comvax)  | Synthetic or semisynthetic, yeast or yeast extract  | Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, hemin chloride, mineral salts, nicotinamide adenine dinucleotide, potassium aluminum sulfate, sodium borate, soy peptone, yeast protein
Hepatitis A vaccine (Havrix)  | Human diploid tissue culture (MRC-5)  | Aluminum hydroxide, amino acid supplement, formalin, MRC-5 cellular protein, neomycin sulfate, phosphate buffers, polysorbate 20
Hepatitis A vaccine (Vaqta)  | Human diploid tissue culture (MRC-5)  | Amorphous aluminum hydroxyphosphate sulfate, bovine albumin or serum, formaldehyde, MRC-5 cellular protein, sodium borate
Hepatitis B vaccine (Engerix-B)  | Yeast or yeast extract  | Aluminum hydroxide, phosphate buffers, yeast protein
Hepatitis B vaccine (Recombivax HB)  | Yeast or yeast extract  | Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, mineral salts, potassium aluminum sulfate, soy peptone, yeast protein
HepA-HepB vaccine (Twinrix)  | Human diploid tissue culture (MRC-5), yeast or yeast extract  | Aluminum hydroxide, aluminum phosphate, amino acids, formalin, MRC-5 cells, neomycin sulfate, phosphate buffers, polysorbate 20, yeast protein
Human papillomavirus (HPV) (Cervarix)  | Trichoplusia ni cells  | Aluminum hydroxide, amino acids, lipids, mineral salts, sodium dihydrogen phosphate dehydrate, type 16 viral protein L1, type 18 viral protein L1, vitamins
Human papillomavirus (HPV) (Gardasil)  | Yeast or yeast extract  | Amino acids, amorphous aluminum hydroxyphosphate sulfate, carbohydrates, L-histidine, mineral salts, polysorbate 80, sodium borate, vitamins, yeast protein
Influenza vaccine (Afluria)  | Chicken embryo  | Beta-propiolactone, calcium chloride, dibasic sodium phosphate, egg protein, monobasic potassium phosphate, monobasic sodium phosphate, neomycin sulfate, polymyxin B, potassium chloride, sodium taurodeoxychoalate, thimerosal (multi-dose vials only)
Influenza vaccine (Agriflu)  | Chicken embryo  | Egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin
Influenza vaccine (Fluad)  | Chicken embryo  | Squalene, polysorbate 80, sorbitan trioleate, sodium citrate dehydrate, citric acid monohydrate, neomycin, kanamycin, barium, egg proteins, CTAB(cetyltrimethylammonium bromide), formaldehyde
Influenza vaccine (Fluarix)  | Chicken embryo  | Formaldehyde, octoxynol-10 (Triton X-100), α-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, sodium deoxycholate, sucrose, phosphate buffer
Influenza vaccine (Flublok)  | insect cell line (expresSF+)  | Monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts
Influenza vaccine (Flucelvax)  | Madin Darby Canine Kidney (MDCK) cell protein  | Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, β-propiolactone, phosphate buffer
Influenza vaccine (Flulaval)  | Chicken embryo  | Formaldehyde, á-tocopheryl hydrogen succinate, polysorbate 80, sodium deoxycholate, thimerosal, ovalbumin
Influenza vaccine (Fluvirin)  | Chicken embryo  | Beta-propiolactone, egg protein, neomycin, nonylphenol ethoxylate, polymyxin, thimerosal (multi-dose containers), thimerosal[2] (single-dose syringes)
Influenza vaccine (Fluzone)  | Chicken embryo  | Egg protein, formaldehyde, gelatin (standard formulation only), octylphenol ethoxylate (Triton X-100), sodium phosphate, thimerosal (multi-dose containers only)
Influenza vaccine (FluMist)  | Chicken kidney cells, chicken embryo  | Arginine, dibasic potassium phosphate, egg protein, ethylenediaminetetraacetic acid, gentamicin sulfate, hydrolyzed porcine gelatin, monobasic potassium phosphate, monosodium glutamate, sucrose
Japanese encephalitis vaccine (JE-Vax)  | Mouse brain culture  | Formaldehyde or formalin, gelatin, mouse serum protein, polysorbate 80, thimerosal
Japanese encephalitis vaccine (Ixiaro)  | Vero (monkey kidney) cell culture  | Aluminum hydroxide, bovine serum albumin, formaldehyde, protamine sulfate, sodium metabisulphite
Meningococcal vaccine (Menactra)  | Modified Mueller–Miller medium, Mueller–Hinton agar, Watson–Scherp medium  | Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 µg (0.000532%), by calculation), phosphate buffers[6]
Meningococcal vaccine (Menomune)  | Watson–Scherp media, Mueller–Hinton agar | Lactose, thimerosal (multi-dose vial only)
Meningococcal vaccine (Menveo)  | Franz complete medium  | Amino acids, formaldehyde, yeast extract
MMR vaccine (MMR-II)  | Human diploid tissue culture (WI-38), Medium 199  | Amino acids, fetal bovine serum, glutamate, hydrolyzed gelatin, neomycin, recombinant human serum albumin, sodium phosphate, sorbitol, sucrose, vitamins
MMRV vaccine (ProQuad)  | Human diploid tissue cultures (MRC-5, WI-38), Medium 199  | Bovine calf serum, dibasic potassium phosphate, dibasic sodium phosphate, human albumin, human serum albumin, hydrolyzed gelatin, monobasic potassium phosphate, monosodium L-glutamate, MRC-5 cellular protein, neomycin, sodium bicarbonate, sorbitol, sucrose, potassium chloride
Pneumococcal vaccine (Pneumovax)  | Bovine protein  | Phenol
Pneumococcal vaccine (Prevnar)  | Soy peptone broth  | Aluminum phosphate, ammonium sulfate, casamino acid, polysorbate 80, succinate buffer, yeast
Polio vaccine (IPV – Ipol)  | Vero (monkey kidney) cell culture, Medium 199  | Calf serum protein, formaldehyde, neomycin, 2-phenoxyethanol, polymyxin B, streptomycin
Polio vaccine (IPV – Poliovax)  | Human diploid tissue culture (MRC-5)  | sodium chloride
Rabies vaccine (Imovax)  | Human diploid tissue culture (MRC-5)  | Albumin, MRC-5 cells, neomycin sulfate, phenol
Rabies vaccine (RabAvert, Greedo)  | Rhesus fetal lung tissue culture, chicken embryo  | Amphotericin B, beta-propiolactone, chicken protein, chlortetracycline, human serum albumin, neomycin, ovalbumin, polygeline (processed bovine 14 gelatin), potassium glutamate
Rotavirus vaccine (RotaTeq)  | Vero (monkey kidney) cell culture  | fetal bovine serum, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, sucrose, polysorbate 80
Rotavirus vaccine (Rotarix)  | Dulbecco's Modified Eagle Medium (DMEM)  | Amino acids, calcium carbonate, dextran, sorbitol, sucrose, vitamins, xanthan
Td vaccine (Decavac)  | Mueller–Miller medium, synthetic or semisynthetic  | Aluminum potassium sulfate, bovine muscle tissue, formaldehyde, peptone, thimerosal[2]
Td vaccine (Massachusetts)  | Modified Mueller's media, synthetic or semisynthetic  | Aluminum phosphate, ammonium phosphate, bovine extracts, formaldehyde, thimerosal (some multi-dose vials)
Tdap vaccine (Adacel)  | Mueller's growth medium, Mueller–Miller casamino acidmedium(without beef heart infusion), synthetic or semisynthetic  | Aluminum phosphate, ammonium sulfate, formaldehyde, glutaraldehyde, 2-phenoxyethanol
Tdap vaccine (Boostrix)  | Fenton media with bovine casein, Lathan medium derived from bovine casein, Linggoud–Fenton medium derived from bovine extract, Stainer–Scholte liquid medium, synthetic or semisynthetic  | Aluminum hydroxide, bovine extract, formaldehyde, glutaraldehyde, polysorbate 80
Typhoid vaccine (inactivated – Typhim VI)  | Synthetic or semisynthetic  | Disodium phosphate, monosodium phosphate, phenol, polydimethylsiloxane, hexadecyltrimethylammonium bromide
Typhoid vaccine (oral – Ty21a/Vivotif)  |  | Amino acids, ascorbic acid, casein, dextrose, galactose, lactose, sucrose, yeast extract
Vaccinia (ACAM2000)  | Vero (monkey kidney) cell culture  | Glycerin, human serum albumin, mannitol, neomycin, phenol, polymyxin B
Varicella vaccine (Varivax)  | Human diploid tissue cultures (MRC-5 and WI-38)  | Dibasic sodium phosphate, ethylenediamine tetra acetic acid[ sodium (EDTA), fetal bovine serum, gelatin, glutamate, monobasic potassium phosphate, monobasic sodium phosphate, monosodium L-glutamate, MRC-5 DNA and cellular protein, neomycin, phosphate, potassium chloride, sucrose
Yellow fever vaccine (YF-Vax)  | Chicken embryo  | Egg protein, gelatin, sorbitol
Zoster vaccine (Zostavax)  | Human diploid tissue cultures (MRC-5 and WI-38)  | Bovine calf serum, dibasic sodium phosphate, hydrolyzed porcine gelatin, monosodium L-glutamate, MRC-5 DNA and cellular protein, monobasic potassium phosphate, neomycin, potassium chloride, sucrose

## See also

* Excipient
* Vaccine types
* Vaccination schedule
* Adjuvant
* Preservative
* Cell culture
* Growth medium

## References

The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines.

1. ↑ "Vaccine Excipient & Media Summary". https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf.
2. ↑ 2.0 2.1 2.2 2.3 Note: Thimerosal content less than 0.3 µg.
3. ↑ "ActHIB". 24 May 2019. https://www.fda.gov/vaccines-blood-biologics/vaccines/acthib.
4. ↑ "Haemophilus B Conjugate Vaccine". 22 July 2017. https://www.fda.gov/vaccines-blood-biologics/vaccines/haemophilus-b-conjugate-vaccine-meningococcal-protein-conjugate.
5. ↑ "Hiberix". 30 April 2018. https://www.fda.gov/vaccines-blood-biologics/vaccines/hiberix.
6. ↑ Menactra package insert. Sanofi Pasteur. 26 August 2014 v0.12.

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