Neglected tropical diseases

Short description: Diverse group of tropical infectious diseases which are common in developing countries

Neglected tropical diseases

Number of people requiring interventions against neglected tropical diseases in 2015[1]
Specialty| Infectious disease

Neglected tropical diseases (NTDs) are a diverse group of tropical infections that are common in low-income populations in developing regions of Africa, Asia, and the Americas.[2] They are caused by a variety of pathogens, such as viruses, bacteria, protozoa, and parasitic worms (helminths) and mites (acarines).[3] These diseases are broadly characterized by neglect within global health policy, contrasted with the "big three" infectious diseases (HIV/AIDS, tuberculosis, and malaria), which generally receive greater treatment and research funding.[4] In sub-Saharan Africa, the effect of neglected tropical diseases as a group is comparable to that of malaria and tuberculosis.[5] NTD co-infection can also make HIV/AIDS and tuberculosis more deadly.[6]

Some treatments for NTDs are relatively inexpensive. For example, praziquantel for schistosomiasis costs about US $0.20 per child per year.[7] Nevertheless, in 2010 it was estimated that control of neglected diseases would require funding of between US$2 billion and $3 billion over the subsequent five to seven years.[8] Some pharmaceutical companies have committed to donating all the drug therapies required, and mass drug administration efforts (for example, mass deworming) have been successful in several countries.[9] While preventive measures are often more accessible in the developed world, they are not universally available in poorer areas.[10]

Within developed countries, neglected tropical diseases affect the very poorest in society. In developed countries, the burdens of neglected tropical diseases are often overshadowed by other public health issues. However, many of the same issues put populations at risk in developed as well as developing nations. For example, other problems stemming from poverty, such as lack of adequate housing, can expose individuals to the vectors of these diseases.[11]

Twenty neglected tropical diseases are prioritized by the World Health Organization (WHO), though other organizations define NTDs differently. Chromoblastomycosis and other deep mycoses, scabies and other ectoparasites, and snakebite envenomation were added to the WHO list in 2017.[12] These diseases are common in 149 countries, affecting more than 1.4 billion people (including more than 500 million children)[13] and costing developing economies billions of dollars every year.[14] They resulted in 142,000 deaths in 2013, down from 204,000 deaths in 1990.[15]

## Contents

* 1 Reasons for neglect
* 1.1 Stigma
* 1.2 Economic incentives
* 1.3 Neglected diseases in developed nations
* 2 List of diseases
* 2.1 Overview
* 2.2 Disease burden
* 3 Diseases
* 3.1 Buruli ulcer
* 3.2 Chagas disease
* 3.3 Dengue and chikungunya
* 3.4 Dracunculiasis
* 3.5 Echinococcosis
* 3.6 Yaws
* 3.7 Foodborne trematodiases
* 3.8 Human African trypanosomiasis
* 3.9 Leishmaniasis
* 3.10 Leprosy
* 3.11 Lymphatic filariasis
* 3.12 Noma
* 3.13 Onchocerciasis
* 3.14 Rabies
* 3.15 Schistosomiasis
* 3.16 Soil-transmitted helminthiasis
* 3.17 Taeniasis and cysticercosis
* 3.18 Trachoma
* 3.19 Chromoblastomycosis and other deep mycoses
* 3.20 Scabies
* 3.21 Snakebite envenoming
* 4 Effects for patients
* 4.1 Social effects
* 4.1.1 Social stigma
* 4.1.2 Mental health
* 4.1.3 Gender
* 4.2 Economic effects
* 4.3 Health effects
* 4.3.1 Coinfection
* 5 Prevention, treatment and eradication
* 5.1 Policy initiatives
* 5.1.1 WHO Roadmap of 2012
* 5.1.2 Others
* 5.2 Deworming treatment
* 5.3 Integration of treatment
* 5.4 Integration with water, sanitation and hygiene (WASH) programs
* 5.5 Pharmaceutical market
* 5.6 NGO initiatives
* 5.7 Public-private initiatives
* 5.7.1 London Declaration on Neglected Tropical Diseases
* 5.7.2 Kigali Declaration on Neglected Tropical Diseases
* 5.8 Others
* 6 Epidemiology
* 7 Research and development
* 7.1 Deficient market
* 7.2 Policy initiatives
* 7.2.1 Public–private partnerships
* 7.2.2 R&D capacity building in middle-income countries
* 7.2.3 Innovation prizes and grants
* 7.2.4 FDA priority review vouchers (PRV)
* 7.2.5 Open source collaboration initiatives
* 8 History
* 9 See also
* 10 References
* 11 External links

## Reasons for neglect

The importance of neglected tropical diseases has been underestimated since many are asymptomatic and have long incubation periods. The connection between death and a neglected tropical disease that has been latent for a long period is often not realized.[16] Areas of high endemicity are often geographically isolated, making treatment and prevention much more difficult.[17]

There are three other major reasons that these diseases have been overlooked: they mainly affect the poorest countries of the developing world; in recent years public health efforts have focused heavily on decreasing the prevalence of HIV/AIDS, tuberculosis, and malaria[18] (far more resources are given to those three diseases because of their higher mortality rates and higher public awareness of them); and neglected tropical diseases do not currently have a prominent cultural figure to champion their elimination.[17][19]

### Stigma

Neglected tropical diseases are often associated with social stigma, making their treatment more complex. Public health research has only recently begun to focus on stigma as a component of the issue. From the 1960s onward, approximately one citation a year related to social stigma. In 2006, there were 458.[20]

Stigma greatly affects disease control by decreasing help-seeking and treatment adherence.[20] Disease control programs since the 1980s have begun to integrate stigma mitigation into their offerings. In India, a leprosy program prioritized the message that "leprosy is curable, not hereditary" in order to inspire optimism in highly affected communities. The goal was to make leprosy a disease "like any other", so as to reduce stigma. At the same time, medical resources were optimized to fulfill the promise that the disease could be cured.[20]

### Economic incentives

Treatment and prevention of neglected tropical diseases are not seen as profitable, so patents and profit play a reduced role in stimulating innovation compared to other diseases. Like all non-commercial areas, communities affected by these diseases are reliant on governments and philanthropy.[21] Currently, the pharmaceutical industry views research and development as highly risky. For this reason, resources are not often put into the field of NTDs, and new chemical products are often expensive. A review of public and private initiatives found that of the 1,393 new chemical products that were marketed between 1975 and 1999, only 16 were related to tropical diseases or tuberculosis. The same review found that there was a 13-fold greater chance of a newly marketed drug being for central nervous system disorders or cancer than for an NTD.[22]

Because of a lack of economic incentives for the pharmaceutical industry, successful NTD treatment programs have often relied on donations. For instance, the Mectizan Donation Program has donated over 1.8 billion tablets of ivermectin.[23] While developed countries often rely on government-run and private partnerships to fund such projects, developing nations frequently have significantly lower per-person spending on these diseases.[22]

A 2006 report found that the Gates Foundation funded most extra activities to counter these diseases.[24][25]

### Neglected diseases in developed nations

Since 2008, the concept of "neglected diseases of poverty" has been developed and explored.[26] This group of diseases, which overlaps with neglected tropical diseases, also pose a threat to human health in developed nations. In the United States alone, there are at least 12 million people with neglected parasitic infections.[26] They make up a hidden disease burden among the poorest people in wealthy societies.[10] In developed nations, lack of knowledge in the healthcare industry and lack of conclusive diagnostic tests perpetuate the neglect of this group of diseases.[27]

In the United States, rates of parasitic infection can be distributed along geographic, racial, and socio-economic lines. Among African Americans, there may be up to 2.8 million cases of toxocariasis. Toxocariasis, trichomoniasis, and some other neglected infections occur in the United States at the same rate as in Nigeria.[10] Within the Hispanic community, neglected infections are concentrated near the US–Mexico border. Vector-borne illnesses are especially high, with some rates approaching those of Latin America. Chagas disease was found in the US as early as the 1970s.[28] However, in the developed world, diseases that are associated with poverty are often not addressed comprehensively. This may be due to a lack of economic incentives and public policy failings. A lack of awareness prevents effective policy generation and leaves healthcare services unequipped to address the issue. Additionally, little effort is put into creating and maintaining large data sets on neglected diseases in the United States and other developed nations. The first summit on the issue was held by the Adler Institute on Social Exclusion in the United States in 2009.[10]

In Europe, a similar trend is seen. Neglected tropical diseases are concentrated in eastern and southern Europe, where poverty levels are highest. The most prevalent diseases in this region are ascariasis, trichuriasis, zoonotic helminth infections, and visceral leishmaniasis. Migration paths to Europe, most notably to Spain, have brought diseases to Europe as well. As many as 6,000 cases of Chagas disease have been introduced in this way. In response to a growing awareness of the burden on these populations, the European Centre for Disease Prevention and Control has laid out ten public health guidelines. They cover a variety of topics, from health education and promotion to community partnerships and the development of a minority healthcare workforce.[10]

## List of diseases

### Overview

There is some debate among the WHO, CDC, and infectious disease experts over which diseases are classified as neglected tropical diseases. Feasey, a researcher in neglected tropical diseases, notes 13 neglected tropical diseases: ascariasis, Buruli ulcer, Chagas disease, dracunculiasis, hookworm infection, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma, and trichuriasis.[18] Fenwick recognizes 12 "core" neglected tropical diseases: the same as above, excluding hookworm.[16]

The WHO recognizes the twenty diseases below as neglected tropical diseases.[12]

WHO[12]/CDC[29] | Type  | PLOS
Major NTDs[30]

|
|

Chagas disease
African trypanosomiasis
Leishmaniasis
| Protozoan infections  |

* Entamoeba histolytica and Naegleria fowleri (both pathogenic amoeba)
* Babesiosis
* Balantidiasis
* Chagas disease
* Giardiasis
* Human African Trypanosomiasis
* Leishmaniasis
* Plasmodium vivax and other non-P. falciparum malarias

Dracunculiasis
Echinococcosis
Lymphatic filariasis
Onchocerciasis
Schistosomiasis
Cysticercosis
Soil-transmitted helminthiasis

Fascioliasis
| Helminth infections  |

* Dracunculiasis
* Echinococcosis
* Food-borne Trematodiases
* Loiasis
* Lymphatic Filariasis
* Onchocerciasis
* Other food-borne helminthiases (Trichinosis, Anisakiasis, Gnathostomiasis)
* Schistosomiasis
* Soil-transmitted helminthiases (Ascariasis, Hookworm Diseases, Trichuriasis, Strongyloidiasis)
* Taeniasis and Cysticercosis
* Toxocariasis and Baylisascaris (caustive agents of VLM).

Dengue & Chikungunya*
Rabies
| Viral infections  |

* Arboviral infections (Dengue, Chikungunya, Zika, Japanese encephalitis, Jungle yellow fever and others)
* Enterovirus 71 and related viruses
* HTLV-1, HTLV-2 and other non-HIV retrovirus infections
* Rabies
* Rift Valley fever
* Viral hemorrhagic fevers

Buruli ulcer
Leprosy
Trachoma
Yaws
| Bacterial infections  |

* Bartonellosis
* Atypical mycobacteria (including Mycobacterium bovis and Buruli ulcer)
* Cholera and other enteric bacteria (Shigella, Salmonella, E. coli)
* Leprosy
* Leptospirosis
* Melioidosis
* Noma
* Relapsing fever
* Trachoma
* Yaws, Bejel and Pinta
* Q fever

Mycetoma and deep mycoses  | Fungal infections  |

* Mycetoma
* Paracoccidioidomycosis
* Chromoblastomycosis
* Other deep tissue mycoses

Scabies and other ectoparasites
| Ectoparasites  |

* Scabies
* Myiasis

Snakebite envenoming
| Non-infectious diseases caused by toxin exposure  |

* Podoconiosis
* Snakebite envenoming

* Only WHO

The World Health Organization's 2010 report on neglected tropical diseases offers an expanded list including dengue, rabies, yaws, cysticercosis, echinococcosis, and foodborne trematode infections.[31]

### Disease burden

Neglected Tropical Diseases Worldwide Burden[32][33] Disease | DALYs (million) | Deaths/Yr | Global Prevalence (million) | Population at Risk (million)

|
|
|
|

Schistosomiasis | 4.5 | 280,000 | 207 | 780
Hookworm | 22.1 | 65,000 | 576 | 3200
Ascariasis | 10.5 | 60,000 | 807 | 4200
Leishmaniasis | 2.1 | 51,000 | 12 | 350
Trypanosomiasis | 1.5 | 48,000 | 0.3 | 60
Chagas disease | 0.7 | 14,000 | 8 | 25
Trichuriasis | 6.4 | 10,000 | 604 | 3200
Leprosy | 0.2 | 6,000 | 0.4 | Not Determined
Lymphatic filariasis | 5.8 | 0 | 120 | 1300
Trachoma | 2.3 | 0 | 84 | 590
Onchocerciasis | 0.5 | 0 | 37 | 90
Cryptococcosis | 12 | 400,000 | 1 | 8

## Diseases

### Buruli ulcer

Main article: Medicine:Buruli ulcer

Buruli ulcer is caused by the bacterium Mycobacterium ulcerans.[34] It is related to the bacteria that cause tuberculosis and leprosy. Mycobacterium ulcerans produces a toxin, mycolactone, that destroys tissue.[34] The prevalence of Buruli ulcer is unknown.[18] The risk of mortality is low, although secondary infections can be lethal.[35] Morbidity takes the form of deformity, disability, and skin lesions, which can be prevented through early treatment with antibiotics and surgery.[35] It is found in Africa, Asia, Australia,[36] and Latin America.[37]

### Chagas disease

Main article: Medicine:Chagas disease

A young boy from Panama with Chagas disease. It has manifested as an acute infection with swelling of one eye (chagoma).

Chagas disease is also known as American trypanosomiasis. There are approximately 15 million people infected with Chagas disease.[18] Morbidity rates are higher for immunocompromised individuals, children, and the elderly, but can be very low if the disease is treated early.[38] Chagas disease does not kill victims rapidly, instead causing years of debilitating chronic symptoms.

It is caused by the vector-borne[39] protozoa Trypanosoma cruzi.[38] It is spread by contact with Trypanosoma cruzi-infected feces of the triatomine (assassin bug). The protozoan can enter the body via the bug's bite, skin breaks, or mucous membranes. Infection can result from eating infected food or coming into contact with contaminated bodily fluids.[38]

There are two phases of Chagas disease. The acute phase is usually asymptomatic. The first symptoms are usually skin chancres, unilateral purplish orbital oedema, local lymphadenopathy, and fever, accompanied by a variety of other symptoms depending on the infection site.[38] The chronic phase occurs in 30 percent of all infections[18] and can take three forms: asymptomatic (most prevalent), cardiac, and digestive lesions.[38]

Chagas disease can be prevented by avoiding insect bites through insecticide spraying, home improvement, bed nets, hygienic food, medical care, laboratory practices, and testing.[38] It can be diagnosed through a serological test, although the test is not very accurate.[18] Treatment is with medication, which may have severe side effects.[38]

### Dengue and chikungunya

Main article: Medicine:Dengue fever

There are 50–100 million dengue virus infections annually.[40] Dengue fever is usually not fatal, but infection with one of four serotypes can increase later susceptibility to other serotypes, resulting in a potentially fatal disease called severe dengue.[40] Dengue fever is caused by a flavivirus which is spread mostly by the bite of the Aedes aegypti mosquito.[40] No treatment for either dengue or severe dengue exists beyond palliative care.[40] The symptoms are high fever and flu-like symptoms.[40] It is found in Asia, Latin America, and Northern Australia.[40]

Chikungunya is an arboviral disease transmitted by A. albopictus and A. aegypti mosquitoes. The virus was first isolated from an outbreak in Tanzania in 1952.[41] Chikungunya virus is a member of the genus Alphavirus and family Togaviridae.[41] The word "chikungunya" is from the Makonde language and means "that which bends up", referring to the effect of debilitating joint pain on the patient.[41] Symptoms, generally appearing 5–7 days after exposure, can be confused with dengue and include fever, rash, headache, joint pain, and swelling.[42] The disease mainly occurs in Africa and Asia.[43]

### Dracunculiasis

Main article: Medicine:Dracunculiasis

Dracunculus medinensis larvae

Dracunculiasis is also known as Guinea-worm disease. In 2019, 53 cases were reported across four countries,[44] a substantial decrease from 3,500,000 cases in 1986.[45] It is not fatal, but can cause months of inactivity.[46] It is caused by drinking water contaminated by water fleas infected with guinea-worm larvae.[46] Approximately one year after infection, a painful blister forms and one or more worms emerge. Worms can be up to 1 metre long.[46]

It is usually treated by World Health Organization volunteers who clean and bandage wounds caused by worms and return daily to pull the worm out a few more inches.[46] Dracunculiasis is preventable by water filtration, immediate case identification to prevent spread, health education, and treating ponds with larvicide. An eradication program has been able to reduce prevalence.[46] As of 2014[update], the four endemic countries are Chad, Ethiopia, Mali, and South Sudan.[46]

### Echinococcosis

Main article: Medicine:Echinococcosis

Lifecycle of Echinococcus

The rate of echinococcosis is higher in rural areas, and there are more than one million people infected currently.[47] It is caused by ingesting parasites in animal feces.[48]

There are two versions of the disease: cystic and alveolar. Both versions involve an asymptomatic incubation period of several years. In the cystic version, liver cysts cause abdominal pain, nausea, and vomiting, while cysts in the lungs cause chronic cough, chest pain, and shortness of breath. In alveolar echinococcosis, a primary cyst develops, usually in the liver, in addition to weight loss, abdominal pain, malaise, and signs of liver failure.[49] Untreated alveolar echinococcosis is fatal.[49]

Surgery and drugs can be used to treat echinococcosis.[49] It can be prevented by deworming dogs, sanitation, proper disposal of animal feces, health education, and livestock vaccination.[50] Cystic echinococcosis is found in the eastern portion of the Mediterranean region, northern Africa, southern and eastern Europe, the southern portion of South America, and Central Asia. Alveolar echinococcosis is found in western and northern China, Russia, Europe, and northern North America.[48] It can be diagnosed through imaging techniques and serological tests.[50]

### Yaws

Main article: Medicine:Yaws

A child with yaws

There are limited data available on the prevalence of yaws, although it primarily affects children.[51] The mortality risk is very low, but the disease causes disfigurement and disability if untreated.[51] The most common symptom is skin lesions.[51] It is a chronic bacterial infection, transmitted by skin contact, and caused by the spirochete bacterium Treponema pallidum pertenue.[51] It is treated with antibiotics and can be prevented through hygiene and sanitation.[51] Yaws is most prevalent in warm, moist tropical regions of the Americas, Africa, Asia, and the Pacific.[51]

### Foodborne trematodiases

Foodborne trematode infections include clonorchiasis, opisthorchiasis, fascioliasis, and paragonimiasis. These infections are all zoonotic, primarily affecting domestic or wild animals, but can also be transmitted to humans. They are acquired by eating food, such as raw fish, contaminated with the larval stages of the parasites. At least 40 million people are thought to be infected.[52]

Fasciola hepatica

### Human African trypanosomiasis

Main article: Medicine:African trypanosomiasis

African trypanosomiasis (African sleeping sickness) is a somewhat rare protozoal disease, with fewer than 10,000 cases currently.[53] Human African trypanosomiasis is vector-borne and spreads through the bite of the tsetse fly.[39] The most common symptoms are fever, headache, lymphadenopathy, sleeping disturbances, personality changes, cognitive decline, and coma. The disease is always fatal if untreated. The current forms of treatment are highly toxic and ineffective, as resistance is spreading. It is diagnosed through an inexpensive serological test.

Lifecycle of African Trypanosomiasis

### Leishmaniasis

Main article: Medicine:Leishmaniasis

Lifecycle of Leishmaniasis

The three forms of leishmaniasis, a protozoal disease, are visceral (Kala-azar), cutaneous, and mucocutaneous.[54] There are an estimated 12 million people infected.[18] It is fatal if untreated, and 20,000 deaths from visceral leishmaniasis occur annually.[55] It is a vector-borne disease caused by the bite of sandflies.[39] At least 90 percent of visceral leishmaniasis occurs in Bangladesh, Brazil, Ethiopia, India, South Sudan, and Sudan. Cutaneous leishmaniasis occurs in Afghanistan, Algeria, Brazil, Colombia, Iran, Pakistan, Peru, Saudi Arabia, and Syria. Around 90 percent of mucocutaneous leishmaniasis occurs in Bolivia, Brazil, and Peru.[54]

A vaccine is under development to prevent leishmaniasis. The only other method of prevention is avoidance of sandfly bites. Diagnosis can be made by clinical signs, serological tests, or parasitological tests.[56] Leishmaniasis can be treated with expensive medications.[57]

### Leprosy

Main article: Medicine:Leprosy

According to recent figures from the WHO, 208,619 new cases of leprosy were reported in 2018 from 127 countries.[58] It is most prevalent in India (69% of cases), Brazil, Indonesia, Nigeria, the Democratic Republic of the Congo, Madagascar, and East Africa from Mozambique to Ethiopia, with the highest relative incidence in India, Brazil, and Nepal.[59] There are one to two million individuals currently disabled or disfigured due to past or present leprosy.[60] It is caused by bacteria and transmitted through droplets from the mouth and nose of infected individuals.[61]

Hands deformed by leprosy

Leprosy causes disfigurement and physical disabilities if untreated. It is curable if treated early.[60] Treatment requires multidrug therapy.[59] The BCG vaccine has some preventative effect against leprosy. Leprosy has a 5–20 year incubation period, and the symptoms are damage to the skin, nerves, eyes, and limbs.[61]

### Lymphatic filariasis

Main article: Medicine:Lymphatic filariasis

Elephantiasis

Lymphatic filariasis is also known as elephantiasis. There are approximately 120 million individuals infected[62] and 40 million with deformities.[16] Approximately two-thirds of cases are in Southwest Asia, and one-third are in Africa.[62] Lymphatic filariasis is rarely fatal[63] but has lifelong implications, such as lymphoedema of the limbs, genital disease, and painful recurrent attacks. Most people are asymptomatic but have lymphatic damage. Up to 40 percent of infected individuals have kidney damage.[64] It is a vector-borne disease, caused by nematode worms that are transmitted by mosquitoes.[39][64]

It can be treated with cost-effective antihelminthic treatments,[65] and washing skin can slow or even reverse damage.[66] It is diagnosed with a finger-prick blood test.[63]

### Noma

Main article: Medicine:Noma (disease)

Noma, an opportunistic bacterial infection causing gangrenous necrosis of the mouth,[67] was added to the World Health Organization's list of neglected tropical diseases in December 2023.[68]

### Onchocerciasis

Main article: Medicine:Onchocerciasis

Onchocerca volvulus emerging from a blackfly

Onchocerciasis is also known as river blindness. There are 20.9 million people infected,[69] and prevalence is higher in rural areas.[70] Over 99 percent of cases are in sub-Saharan Africa.[70] It causes blindness, skin rashes, lesions, intense itching, and skin depigmentation.[70][71] It is a vector-borne disease, caused by blackflies infected with the filarial nematode Onchocerca volvulus.[39][71]

It can be treated with ivermectin[71] and prevented by insecticide spraying or preventative dosing with ivermectin.[70]

### Rabies

Main article: Medicine:Rabies

Rabies virus

There are two forms of rabies: furious and paralytic. It is mostly found in Asia and Africa.[72] There is a higher prevalence in rural areas, and it disproportionately affects children.[73] Rabies is fatal after symptoms develop.[74] It is caused by a lyssavirus transmitted through wounds or bites from infected animals.[73]

The first symptoms are fever and pain near the infection site, which occur after a one- to three-month incubation period. Furious rabies (the more common type) causes hyperactivity, hydrophobia, and aerophobia; death by cardio-respiratory arrest occurs within days. Paralytic rabies causes a slow progression from paralysis to coma to death.[73] There are 60,000 deaths from rabies annually.[72]

It can be prevented in dogs by vaccination[73] and by cleaning and disinfecting bite wounds and post-exposure prophylaxis.[74] Rabies is undiagnosable before symptoms develop. It can be detected through tissue testing after symptoms develop.[73]

### Schistosomiasis

Main article: Medicine:Schistosomiasis

11-year-old Filipino boy with ascites due to schistosomiasis

There are over 200 million cases of schistosomiasis.[16] Approximately 85 percent of cases are in sub-Saharan Africa.[16] The disease can be fatal by causing bladder cancer and hematemesis.[16] Schistosoma species have a complex life cycle that alternates between humans and freshwater snails. Infection occurs when the skin comes into contact with contaminated fresh water in which snails that carry the parasite are living. Symptoms for schistosomiasis are not caused by the worms but by the body's reaction to the eggs. The eggs that do not pass out of the body can become lodged in the intestine or bladder, causing inflammation or scarring. Children who are repeatedly infected can develop anemia, malnutrition, and learning difficulties.[75] The symptoms are usually haematuria, bladder obstruction, renal failure, bladder cancer, periportal fibrosis, bladder fibrosis, liver fibrosis, portal hypertension, cervical lesions, ascites, and esophageal varices.[18][16]

Inexpensive praziquantel can be used to treat individuals with schistosomiasis, but it cannot prevent reinfection. The cost of prevention is US$0.32 per child per year.[16] Mass deworming treatment with praziquantel, better access to safe water, sanitation, and health education can all be used to prevent schistosomiasis.[18] Vaccines are under development. It can be diagnosed through a serological test, but the test often produces false negatives.[16]

### Soil-transmitted helminthiasis

Main article: Medicine:Soil-transmitted helminthiasis

Adult ascaris worms being removed from the bile duct of a patient in South Africa

Soil-transmitted helminthiasis is the most prevalent neglected tropical disease.[76] The four major worm species responsible for soil-transmitted helminthiasis are Ascaris (roundworms), Trichuris (whipworm), the hookworms Necator americanus and Ancylostoma duodenale, and Strongyloides stercoralis.[77] There are 1.5 billion people currently infected.[77] Soil-transmitted helminthiasis occurs in sub-Saharan Africa, the Americas, China, and East Asia.[77] The mortality risk is very low.[18] The most common symptoms are anemia, stunted growth, intestinal problems, lack of energy, and compromised physical and cognitive development.[18][77] Infected children often fall behind in schooling.[18] The severity of symptoms depends on the number of worms in the body.[77]

Parasitic worms are generally transmitted via exposure to infected human feces and soil that are spread in the environment, for example, due to open defecation.[77] The most common treatment is medicine.[77] It can be prevented through hygienically prepared food and clean water, improved sanitation, periodic deworming, and health education.[77] The World Health Organization recommends mass deworming without prior diagnosis.[77]

### Taeniasis and cysticercosis

Main article: Medicine:Cysticercosis

Cysticercosis is an infection by larvae of the pork tapeworm Taenia solium, while taeniasis is infection by adult Taenia species tapeworms, including T. solium, the beef tapeworm T. saginata and the Asian tapeworm T. asiatica.[78][79] Both cysticercosis and taeniasis are found in Asia, Africa, and Latin America, particularly on farms in which pigs are exposed to human excrement.[80]

Cysticercosis is the most common preventable cause of epilepsy in the developing world.[80] Cysticercosis occurs after ingestion of food, water, or soil contaminated by human fecal matter.[78] Cysts and lesions can cause headaches, blindness, seizures, hydrocephalus, meningitis, and dementia.[81] Neurocysticercosis, or the parasitic infection of the nervous system, can be fatal.

Taeniasis is not fatal.[80][81] It is usually contracted after eating undercooked contaminated pork or beef. Taeniasis has mild symptoms, including abdominal pain, nausea, diarrhea, or constipation, although cholangitis and appendicitis have been reported due to internal movement of motile proglottids,[79] and intestinal obstruction by large T. saginata occasionally occurs.[82]

Drugs are used to treat both diseases.[81] Infection can be prevented through stricter meat-inspection standards, livestock confinement, improved hygiene and sanitation, health education, safe meat preparation, and identifying and treating human and pig carriers.[83]

### Trachoma

Main article: Medicine:Trachoma

There are 21.4 million people infected with trachoma, of whom 2.2 million are partially blind and 1.2 million are blind. It is found in Africa, Asia, Central and South America, the Middle East, and Australia.[84] The disease disproportionately affects women and children.[84] The mortality risk is very low, although multiple re-infections eventually lead to blindness.[18][84] The symptoms are internally scarred eyelids, followed by eyelids turning inward.[84] Trachoma is caused by a micro-organism that spreads through eye discharges (on hands, cloth, etc.) and by "eye-seeking flies".[84]

### Chromoblastomycosis and other deep mycoses

This section is an excerpt from Chromoblastomycosis[ edit ]

Other important endemic mycoses with common systemic involvement are histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, blastomycosis and talaromycosis. These infections are also seldomly seen in returning travelers in western countries[85]

### Scabies

This section is an excerpt from Scabies[ edit ]

### Snakebite envenoming

Main article: Medicine:Snakebite

Snakebite was added to the list in 2017, after years of criticism of the WHO by activists for not making it a priority.[86] The greatest burden of snakebite morbidity is in India and Southeast Asia. Snakebite envenoming (SBE) affects as many as 2.7 million people every year, most of whom live in some of the world's most remote, poorly developed, and politically marginalised tropical communities. With annual mortality of 81,000 to 138,000 and 400,000 surviving victims suffering permanent physical and psychological disabilities, SBE is a disease in urgent need of attention[87], but snakebites often go unreported.[88] A policy analysis however found that the placement of snakebite in the global health agenda of WHO is fragile due to reluctance acceptance of the disease in the neglected tropical disease community and the perceived colonial nature of the network driving the agenda.[89]

This section is an excerpt from snakebite[ edit ]

## Effects for patients

### Social effects

#### Social stigma

Several NTDs, such as leprosy, cause severe deformities that result in social stigma. Stigma is considered to be the "hidden burden" of NTDs and is not accounted for in measures such as disability-adjusted life years (DALYs). Other NTDs that carry heavy social stigma include onchocerciasis, lymphatic filariasis, plague, Buruli ulcer, leishmaniasis, and Chagas disease.[20] Lymphatic filariasis, for example, causes severe deformities that can result in denial of marriage and inability to work.[16] Studies in Ghana and Sri Lanka have demonstrated that support groups for patients with lymphatic filariasis can increase participants' self-esteem, quality of life, and social relations through social support and providing practical advice on how to manage their illness. The social effects of neglected tropical diseases have been shown to affect men and women in different ways. Men are socially stigmatized in a way that detrimentally affects their economic prospects. Women are more likely to be affected in the areas of marriage and family.[20]

#### Mental health

A 2012 review found that infection with a neglected tropical disease predisposes individuals to poor mental health. This is partially due to the social stigma that surrounds NTDs, but is also likely caused by the subsequent lack of access to health and social services. Overall, being a member of the infected community was found to cut individuals off from multiple aspects of society via civic rights, educational opportunities, and employment.[90] A high prevalence of post-traumatic stress disorder (PTSD) and depression was found among people who had survived snakebites.[91] More research needs to be directed to understanding psychological aspects of NTDs to understand their effects more fully[90] and to direct strategies to manage them better in healthcare systems where mental health professionals are scarce.[91]

#### Gender

NTDs disproportionately affect women and children.[92] There is also added risk of hookworm infection during pregnancy and potential to transfer diseases such as Chagas during pregnancy. A study in Uganda found that women were able to obtain treatment more easily than men because they had fewer occupational responsibilities and were more trusting of treatments, but ignorance of the effects of medicines during pregnancy prevented adequate care. The paper concludes that gender should be considered when designing treatment programs in Uganda.[93] Additionally, women often bear a heavier social stigma in relation to the pressure to marry.[16]

### Economic effects

The cost of treatment of some of these diseases, such as Buruli ulcer, can be almost the average household income for families in the highest quarter of incomes, while for those in the lowest quarter it can be over twice the yearly income. These enormous financial costs often cause deferral of treatment and financial ruin. These diseases also cost the government in terms of healthcare provision and lost worker productivity through morbidity and shortened life spans. In Kenya, for example, deworming is estimated to increase average adult income by 40 percent, which is a benefit-to-cost ratio of 100. Each untreated case of trachoma is estimated to cost US$118 in lost productivity. Each case of schistosomiasis causes a loss of 45.4 days of work per year. Most of the diseases cost the economies of developing countries millions of dollars. Large-scale prevention campaigns are predicted to increase agricultural output and education levels.[94]

The low cost of treatment for NTDs can be attributed to the large scale of the programs, free provision of drugs by pharmaceutical companies, delivery modes of drugs, and unpaid volunteers who distribute the drugs. The economic burden of NTDs is undervalued and therefore the corresponding economic effect and cost-effectiveness of decreasing prevalence of NTDs is underestimated.[94] The investment return on measures to control NTDs is estimated to be between 14 and 30 percent, depending on the disease and region.[95]

### Health effects

#### Coinfection

Coinfection is a major concern with NTDs, making them more damaging than their mortality rates might suggest. Because factors such as poverty, inadequate healthcare and inadequate sanitation practices contribute to all NTDs, they are often found in overlapping distributions. Helminth infections, as the most common infection of humans, are often found to be in multi-infection systems. For example, in Brazil, low socioeconomic status contributes to overcrowded housing. In these same areas, coinfection by Necator americanus and Schistosoma mansoni is common. The effect of each worm weakens the immune system, making infection from the other more likely and more severe. For this reason, coinfection carries a higher risk of mortality. NTDs may also play a role in infection with other diseases, such as malaria, HIV/AIDS, and tuberculosis. The ability of helminths to manipulate the immune system may create a physiological environment that could exacerbate the progression of HIV/AIDS.[96] Some evidence from Senegal, Malawi, and Thailand has shown that helminth infections raise the risk of malarial infection.[97]

## Prevention, treatment and eradication

Eliminating NTDs in Côte d'Ivoire through education and distribution of anti-parasitic drugs

Prevention and eradication are important because "of the appalling stigma, disfigurement, blindness and disabilities caused by NTDs."[16] The principal aim of the London Declaration on Neglected Tropical Diseases was the elimination or eradication of dracunculiasis, leprosy, lymphatic filariasis, onchocerciasis, trachoma, sleeping sickness, visceral leishmaniasis, and canine rabies within ten years of its launch in January 2012.[4] The declaration is a collaborative effort involving the WHO, the World Bank, the Bill & Melinda Gates Foundation, the world's 13 leading pharmaceutical companies, and government representatives from the US, UK, United Arab Emirates, Bangladesh, Brazil, Mozambique, and Tanzania.

While there has been a noticeable uptick in biological research into NTDs, prevention may be supplemented by social and development outreach. Spiegel and coauthors advocated for "social offset", which reallocates some funding for biotechnological research to social programs. This attempts to alleviate some of the factors (such as poverty, poor sanitation, overcrowding and poor healthcare) that greatly exacerbate conditions brought on by NTDs. Projects such as these also strengthen the goal of sustained eliminations rather than quickly addressing symptoms.[98]

### Policy initiatives

There are many prevention and eradication campaigns funded by organizations such as the World Health Organization, US Agency for International Development, Bill & Melinda Gates Foundation, and UK Department for International Development.[16]

Sustainable Development Goal 3 has the target: "By 2030, [to] end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases."[99]

#### WHO Roadmap of 2012

In 2012, WHO published an NTD "roadmap", which contained milestones for 2015 and 2020, and specified targets for eradication, elimination and intensified control of the different NTDs.[100] For example:

* NTDs planned to be eradicated: dracunculiasis by the year 2015, endemic treponematoses (yaws) by 2020
* NTDs planned to be eliminated globally by 2020: blinding trachoma, leprosy, human African trypanosomiasis, and lymphatic filariasis
* NTDs planned to be eliminated in certain regions: rabies (by 2015 in Latin America, by 2020 in Southeast Asia and the western Pacific), Chagas disease (transmission through blood transfusion by 2015, intra-domiciliary transmission by 2020 in the Americas), visceral leishmaniasis (by 2020 in the Indian subcontinent), onchocerciasis (by 2015 in Latin America), and schistosomiasis (by 2015 in the eastern Mediterranean region, the Caribbean, Indonesia, and the Mekong River basin, and by 2020 in the Americas and western Pacific)
* NTDs planned to be eliminated in certain countries: human African trypanosomiasis (by 2015 in 80 percent of areas in which it occurs), onchocerciasis (by 2015 in Yemen, by 2020 in selected countries in Africa), and schistosomiasis (by 2020 in selected countries in Africa)
* Intensified control with specific targets for 2015 and 2020 are provided for these NTDs: dengue, Buruli ulcer, cutaneous leishmaniasis, taeniasis/cysticercosis and echinococcosis/hydatidosis, foodborne trematode infections, and soil-transmitted helminthiases.

In 2021, WHO updated their NTD roadmap "Together towards 2030", outlining their approach for 2021–2030.[101][102]: v–vi

#### Others

The U.S. Food and Drug Administration priority review voucher is an incentive for companies to invest in new drugs and vaccines for tropical diseases. A provision of the Food and Drug Administration Amendments Act of 2007 awards a transferable "priority review voucher" to any company that obtains approval for a treatment for one of the listed diseases. The voucher can later be used to accelerate the review of an unrelated drug. This program is for all tropical diseases and includes medicines for malaria and tuberculosis. The first voucher given was for Coartem, a malaria treatment.[103]

The prize was proposed by Duke University faculty Henry Grabowski, Jeffrey Moe, and David Ridley in their 2006 Health Affairs paper "Developing Drugs for Developing Countries".[104] In 2007, United States Senators Sam Brownback (R-KS) and Sherrod Brown (D-OH) sponsored an amendment to the Food and Drug Administration Amendments Act of 2007. President George W. Bush signed the bill in September 2007.

### Deworming treatment

Deworming treatments in infected children may have some nutritional benefit, as worms are often partially responsible for malnutrition.[16][105] However, in areas where these infections are common, there is strong evidence that mass deworming campaigns do not have a positive effect on children's average nutritional status, levels of blood haemoglobin, cognitive abilities, performance at school, or survival.[105] To achieve health gains in the longer term, improvements in sanitation and hygiene behaviours are also required, together with deworming treatments.

The effect of mass deworming on school attendance is disputed. It has been argued that mass deworming has a positive effect on school attendance.[16] The long-term benefits of deworming include a decrease in school absenteeism by 25 percent and an increase in adult earnings by 20 percent.[106] A systematic review, however, found that there is little or no difference in attendance in children who receive mass deworming compared to children who did not.[107] One study found that boys were enrolled in primary school for more years than boys who were in schools that did not offer such programs. Girls in the same study were about a quarter more likely to attend secondary school if they received treatment. Both groups went on to participate in more skilled sectors of the labor market. The economic growth generated from school programs such as this may balance out the actual expenses of the program.[108] However, the results of this study are disputed (due to a high risk of bias in the study), and the positive long-term outcomes of mass deworming remain unclear.[107]

### Integration of treatment

School nurse checks student's health in Kenya

Inclusion of NTDs into initiatives for malaria, HIV/AIDS, and tuberculosis, as well as integration of NTD treatment programs, may have advantages given the strong link between these diseases and NTDs.[4][97][109] Some neglected tropical diseases share common vectors (sandflies, black flies, and mosquitos).[97] Both medicinal and vector control efforts may be combined.[110]

A four-drug rapid-impact package has been proposed that targets multiple diseases together. This package is estimated to cost US$0.40 per patient, with estimated saving of 26–47% compared to treating the diseases separately. While more research must be done in order to understand how NTDs and other diseases interact in both the vector and the human stages, safety assessments have so far produced positive results.[97]

Many neglected tropical diseases and other prevalent diseases share common vectors, creating another opportunity for treatment and control integration. One such example of this is malaria and lymphatic filariasis, which are both transmitted by the same or related mosquito vectors. Vector control, through the distribution of insecticide-treated nets, reduces human contact with a wide variety of disease vectors. Integrated vector control may also alleviate pressure on mass drug administration, especially with respect to rapidly evolving drug resistance. Combining vector control and mass drug administration deemphasizes both, making each less susceptible to resistance evolution.[110]

### Integration with water, sanitation and hygiene (WASH) programs

Water, sanitation, and hygiene (WASH) interventions are essential in preventing many NTDs, such as soil-transmitted helminthiasis.[111] Mass drug administration alone will not protect people from re-infection. A more holistic and integrated approach to NTDs and WASH efforts will benefit both sectors along with the communities they are aiming to serve. This is especially true in areas where more than one NTD is endemic.[111]

In August 2015, the World Health Organization unveiled a global strategy and action plan to integrate WASH with other public health interventions to accelerate the elimination of NTDs.[112] The plan aimed to intensify control or eliminate certain NTDs in specific regions by 2020, and referred to the NTD "roadmap" milestones from 2012 that included eradication of dracunculiasis by 2015 and of yaws by 2020, elimination of trachoma and lymphatic filariasis as public health problems by 2020, and intensified control of dengue, schistosomiasis, and soil-transmitted helminthiases.[27][102]

Closer collaboration between WASH and NTD programmes can lead to synergies. They can be achieved through collaborative planning, delivery and evaluation of programmes, strengthening and sharing of evidence, and using monitoring tools to improve the equity of health services.[113]

Reasons why WASH plays an important role in NTD prevention and patient care include:[27]

* NTDs affect more than one billion people in 149 countries. They occur mainly in regions with a lack of basic sanitation. About 2.4 billion people worldwide do not have adequate sanitation facilities. 663 million do not have access to improved drinking water sources.[114]
* A leading cause of preventable blindness is trachoma. The bacterial infection is transmitted through contact with eye-seeking flies, fingers, and fomites. Prevention components are facial cleanliness, which requires water for face washing, and environmental improvement, which includes safe disposal of excreta to reduce fly populations.[115]
* Improved sanitation prevents soil-transmitted helminthiases. It impedes fecal pathogens such as intestinal worm eggs from contaminating the environment and infecting people through contaminated food, water, dirty hands, and direct skin contact with the soil.[116]
* Improved sanitation and water management can contribute to reduced proliferation of mosquitoes that transmit diseases, such as lymphatic filariasis, dengue, and chikungunya. Breeding of the Culex mosquito, which transmits filarial parasites, is facilitated through poorly constructed latrines. Breeding of the Aedes aegypti and Aedes albopictus mosquitoes, which transmit dengue and chikungunya, can be prevented through safe storage of water.[117]
* Feces and urine that contain worm eggs can contaminate surface water and lead to transmission of schistosomiasis. This can be prevented through improved sanitation. Not only human but also animal (cow, buffalo) urine or feces can transmit some schistosome species. Therefore, it is important to protect freshwater from animals and animal waste.[118]
* Treatment of many NTDs requires clean water and hygienic conditions for healthcare facilities and households. For Guinea-worm disease, Buruli ulcer, and cutaneous leishmaniasis, wound management is needed to speed up healing and reduce disability. Lymphatic filariasis causes chronic disabilities. People who have this disease need to maintain rigorous personal hygiene with water and soap to prevent secondary infections.[119]
* NTDs that lead to permanent disabilities make tasks such as carrying water long distances or accessing toilets difficult. However, people affected by these diseases often face stigma and can be excluded from accessing water and sanitation facilities. This increases their risk of poverty and severe illness. Clean water and soap are essential for these groups to maintain personal hygiene and dignity. Therefore, additional efforts to reduce stigma and exclusion are needed. In this manner, WASH can improve the quality of life of people affected by NTDs.[120]
* In a meta-analysis, safe water was associated with significantly reduced odds of Schistosoma infection, and adequate sanitation was associated with significantly lower odds of infection with both S. mansoni and S. haematobium.[121]
* A systematic review and meta-analysis showed that better hygiene in children is associated with lower odds of trachoma. Access to sanitation was associated with 15 percent lower odds of active trachoma and 33 percent lower odds of C. trachomatis infection of the eyes.[122]
* Another systematic review and meta-analysis found a correlation between WASH access and practices, and lower odds of soil-transmitted helminthiasis infections by 33 to 77 percent. Persons who washed their hands after defecating were less than half as likely to be infected as those who did not.[123] Traditionally, preventive chemotherapy is used as a measure of control, although this measure does not stop the transmission cycle and cannot prevent reinfection. In contrast, improved sanitation can.[124]

### Pharmaceutical market

Biotechnology companies in the developing world have targeted neglected tropical diseases due to a need to improve global health.[125]

Mass drug administration is considered a possible method for eradication, especially for lymphatic filariasis, onchocerciasis, and trachoma, although drug resistance is a potential problem.[126] According to Fenwick, Pfizer donated 70 million doses of drugs in 2011 to eliminate trachoma through the International Trachoma Initiative.[16] Merck has helped The African Programme for the Control of Onchocerciasis (APOC) and Oncho Elimination Programme for the Americas to greatly diminish the effect of onchocerciasis by donating ivermectin.[16] Merck KGaA pledged to give 200 million tablets of praziquantel, the only cure for schistosomiasis, over 10 years.[127] GlaxoSmithKline has donated two billion tablets of medicine for lymphatic filariasis and pledged 400 million deworming tablets per year for five years in 2010. Johnson & Johnson has pledged 200 million deworming tablets per year.[16] Novartis has pledged leprosy treatment, and EISAI pledged two billion tablets to help treat lymphatic filariasis.[16]

### NGO initiatives

Non-governmental organizations that focus exclusively on NTDs include the Schistosomiasis Control Initiative, Deworm the World, and the END Fund.[128] Despite under-funding, treatment and prevention of many neglected diseases is cost-effective. The cost of treating a child for infection of soil-transmitted helminths and schistosomes (some of the main causes of neglected diseases) is less than US$0.50 per year when administered as part of school-based mass deworming by Deworm the World. This programme is recommended by Giving What We Can and the Copenhagen Consensus Centre as one of the most efficient and cost-effective solutions. The efforts of the Schistosomiasis Control Initiative to combat neglected diseases include the use of rapid-impact packages: supplying schools with packages including four or five drugs, and training teachers in how to administer them. Health Action International based in Amsterdam worked with the WHO to get snakebite envenoming on the list of neglected tropical diseases.[86]

### Public-private initiatives

An alternative to the profit-driven drug development model emerged in 2000 to address the needs of these neglected patients. Product development partnerships (PDPs) aim at implementing and accelerating the research and development (R&D) of safe and effective health tools (diagnostics, vaccines, drugs) to combat neglected diseases.[129] Drugs for Neglected Disease initiative (DNDi) is one of these PDPs that has already developed new treatments for NTDs.[130]

The Sabin Vaccine Institute, founded in 1993, works to address the issues of vaccine-preventable diseases as well as NTDs. They run three main programs: Sabin Vaccine Development, Global Network for Neglected Tropical Diseases, and Vaccine Advocacy and Education.[131] Their product development partnership affiliates them with the Texas Children's Hospital as well as the Baylor College of Medicine. Their major campaign, End7, aims to end seven of the most common NTDs (elephantiasis, river blindness, snail fever, trachoma, roundworm, whipworm, and hookworm) by 2020. Through End7, college campuses undertake fundraising and educational initiatives for the broader goals of the campaign.[132]

WIPO Re:Search was established in 2011 by the World Intellectual Property Organization in collaboration with BIO Ventures for Global Health (BVGH) and with the active participation of leading pharmaceutical companies and other private and public sector research organizations. It allows organizations to share their intellectual property, compounds, expertise, facilities, and know-how royalty-free with qualified researchers worldwide working on new solutions for NTDs, malaria, and tuberculosis.[133][134]

In 2013, the Government of Japan, five Japanese pharmaceutical companies, the Bill and Melinda Gates Foundation, and the UNDP established a new public–private partnership, the Global Health Innovative Technology Fund. They pledged over US$100 million to the fund over five years, to be awarded as grants to R&D partnerships across sectors in Japan and elsewhere, working to develop new drugs and vaccines for 17 neglected diseases, in addition to HIV, malaria, and tuberculosis.[135][136][137] Affordability of the resulting drugs and vaccines is one of the key criteria for grant awards.[135]

#### London Declaration on Neglected Tropical Diseases

The London Declaration on Neglected Tropical Diseases, initiated by the Bill and Melinda Gates Foundation launched on 30 January 2012 in London. Inspired by the WHO roadmap to eradicate or prevent transmission for neglected tropical diseases, it aimed to eradicate or reduce NTDs by the year 2020.[138] It was endorsed by governments and organisations around the world, as well as major pharmaceutical companies including Abbott, AstraZeneca, Bayer HealthCare Pharmaceuticals, Becton Dickinson, Bristol-Myers Squibb, Eisai, Gilead Sciences, GlaxoSmithKline, Johnson & Johnson, Merck KGaA, Merck Sharp & Dohme, MSD, Novartis, Pfizer, and Sanofi.[139] It was not a complete success, but millions of lives were saved, the burden of the infections was reduced, and 42 countries eliminated at least one disease.[140] To commemorate the programme, WHO adopted 30 January as the World NTD Day.[141]

#### Kigali Declaration on Neglected Tropical Diseases

The Kigali Declaration on Neglected Tropical Diseases was launched at the Kigali Summit on Malaria and Neglected Tropical Diseases (NTDs) hosted by the Government of Rwanda at its capital city Kigali on 23 June 2022.[142] It was signed as a support for the World Health Organization's 2021–30 road map for NTDs and the target of Sustainable Development Goal 3 to end NTD epidemics; and as a follow-up project of the London Declaration .[143] Supported by WHO, governments of the Commonwealth of Nations pledged the endorsement, along with commitments from GSK plc, Novartis, and Pfizer.[144]

### Others

An open-access journal dedicated to neglected tropical diseases called PLoS Neglected Tropical Diseases first began publication in 2007.

One of the first large-scale initiatives to address NTDs came from a collaboration between Kenneth Warren and the Rockefeller Foundation. Ken Warren is regarded as a pioneer in neglected tropical disease research. The Great Neglected Tropical Diseases Network was a consortium of scientists from all over the world, hand-picked by Warren, working to expand the research base in neglected diseases. Many of the scientists that he recruited had not been involved in NTD research before. The network ran from 1978 to 1988. Warren's vision was to establish units within biological labs across the world, dedicated to R&D. By forming a critical mass of scientists in NTD research, he hoped to attract new students into the field. The interdisciplinary group met annually to update the community on research progress. Much of the work done by this group focused on understanding the mechanisms behind infection. At these informally structured meetings, research partnerships were formed. Warren himself encouraged these partnerships, especially if they bridged the divide between developed and developing nations. Through the Great Neglected Tropical Disease Network, a great number of scientists were brought into the field of parasitology.[145]

## Epidemiology

See also: Medicine:Neglected tropical diseases in India

Global overlap of six of the common NTDs, specifically guinea worm disease, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma, in 2011

The distribution of neglected tropical disease disproportionally affects about one billion of the world's poorest populations,[146] causing mortality, disability, and morbidity.[147] Lack of funding, resources, and attention can result in treatable and preventable diseases causing death.[148] Factors like political dynamics, poverty, and geographical conditions can make the delivery of NTD control programs difficult.[146] Intersectional collaboration of poverty reduction policies and neglected tropical diseases creates cross-sector approaches to simultaneously address these issues.[146]

The six most common NTDs include soil-transmitted helminths (STHs)—specifically roundworms (Ascaris lumbricoides), whipworm (Trichuris trichiura), and hookworms (Necator americanus and Ancylostoma duodenale)—schistosomiasis, trachoma, and lymphatic filariasis (LF).[111] These diseases affect one-sixth of the world's population, with 90 percent of the disease burden occurring in sub-Saharan Africa.[111]

Information on the frequency of neglected tropical diseases is of low quality. It is currently difficult to summarize all of the information on this family of diseases. One effort to do so is the Global Burden of Disease framework. It aims to create a standardized method of measurement. The principle components of the approach involve 1) the measuring of premature mortality as well as disability, 2) the standardized usage of DALYs (disability-adjusted life years), and 3) widespread inclusion of diseases and injury causes with the estimation of missing data.[149] However, the DALY has been criticized as a "systematic undervaluation" of disease burden. King[150] asserts that DALY emphasizes the individual too much while ignoring the effects of the ecology of the disease. In order for the measure to become more valid, it may have to take the context of poverty more into account. King also emphasizes that DALYs may not capture the non-linear effects of poverty on the cost-utility analysis of disease control. The Socio-Demographic Index (SDI) and Healthy Life Expectancy (HALE) are other summary measures that can be used to take into account other factors.[151] HALE is a metric that weights years lived and health loss before death to provide a summary of population health.[151] SDI is a measurement that includes lag-distributed income per capita, average education, and fertility rate.[147] Socioeconomic factors greatly influence the distribution of neglected tropical diseases, and not addressing these factors in models and measurements can lead to ineffective public health policy.[148]

## Research and development

The structure of two of the ivermectins, an important class of drug in the control of Onchocerciasis.

The diseases considered neglected tropical diseases vary. Some researchers no longer consider malaria, HIV, and tuberculosis to be neglected due to the amount of public attention and increased funding they have received. Outside "The Big Three", the seven most prevalent neglected tropical diseases in order of their global prevalence are ascariasis, trichuriasis, hookworm infection, schistosomiasis, lymphatic filariasis, and trachoma.[33] These seven are among a larger list of thirteen major NTDs: onchocerciasis, leishmaniasis, Chagas disease, leprosy, human African trypanosomiasis (sleeping sickness), dracunculiasis, and Buruli ulcer.[33]

### Deficient market

In their 2002 review of the U.S. Food and Drug Administration (FDA) databases and the European Agency for the Evaluation of Medicinal Products, Troullier et al. found that 16 out of 1393 new chemical entities were approved for NTDs between 1975 and 1999 (~1%).[152] Cohen et al. revisited the data and using the same methodology found 32 new chemical entities during the time period.[153] In a second analysis using an expanded list of NTDs based on the G-FINDER survey,[154] the number was slightly higher, with 46 new drugs and vaccines approved (~3% of the total including HIV drugs).[153] Between 2000 and 2009, there has been some increase with an additional 26 newly approved drugs and vaccines for NTDs.[153]

A number of factors are recognized as contributing to the low number. The barrier most reported is the high cost of drug development. Estimates are that pharmaceutical companies' development costs to approval fall between $500 million and $2 billion.[155] DiMasi, Hansen, and Grabowski calculated an average of $802 million in year 2000 dollars.[156] Furthermore, the time that drugs are approved for use averages seven years out of the twenty years on patent, meaning a tendency for the market to focus on diseases of developed nations where high prices can be used to recoup research and development costs, and subsidize failed R&D efforts. In short, NTD research and development is considered a high investment risk, given that NTDs predominantly affect the poor in low- and middle-income countries.[157][158] Additional barriers include drug safety regulatory requirements, intellectual property protection problems, and poor infrastructure for distribution and sales.[159][157]

Although drug companies have not invested heavily in NTDs, in several cases, rather than focus on profits, some have decided to donate key drugs to address NTDs. For example, Merck has had a program since the mid-1980s to donate ivermectin (Mectizan) indefinitely to support the global fight against onchocerciasis. GlaxoSmithKline and several other large pharmaceutical companies have donation programs as well. Drug donation, however, does not ameliorate the deficiency of new chemical entities being researched and developed. This is especially of concern with reports of emerging resistance among existing drugs.[160][161]

### Policy initiatives

#### Public–private partnerships

Melinda and Bill Gates speak during press conference at the World Economic Forum in Davos, Switzerland, January 30, 2009.

Major PPPs for NTDs include: the Sabin Vaccine Institute, Norvartis Vaccines Institute for Global Health, MSD Wellcome Trust Hilleman Laboratories, Infectious Diseases Research Institute, Institut Pasteur and INSERM, WIPO Re:Search, and the International Vaccine Institute.[158] Likewise, a number of new academic drug development centers have been created in recent years drawing in industry partners. Support for these centers is frequently traced to the Bill & Melinda Gates Foundation, the Sandler Foundation, and the Wellcome Trust.[162]

#### R&D capacity building in middle-income countries

#### Innovation prizes and grants

Competitive innovation prizes have been used to spur development in a range of fields such as aerospace engineering, clean technology, and genomics. The X-Prize Foundation is launching a competition for high-speed, point-of-care diagnostics for tuberculosis. A more widely defined annual "Global Health EnterPrize" for neglected tropical diseases has been proposed to reward health innovators, particularly those based in countries where NTDs represent a serious health burden.{{citation needed|date=June 2012}

#### FDA priority review vouchers (PRV)

However, PRVs have been criticized as being open to manipulation and possibly encouraging errors through too rapid regulatory decision-making.[163]

#### Open source collaboration initiatives

The Drugs for Neglected Diseases Initiative, a web-focused not-for-profit drug R&D organization dedicated to creating new NTD treatments.

Several companies and scientific organizations are participating in open-source initiatives to share drug data and patent information over the web, and facilitate virtual collaboration on NTD research.

One rich area to explore is the wealth of genomic data resulting from the sequencing of parasite genomes. These data offer opportunities for the exploration of new therapeutic products using computational and open-source collaboration methods for drug discovery.[164][165] The Tropical Disease Initiative, for example, has used large amounts of computing power to generate the protein structures for ten parasite genomes. An open-source drug bank was matched algorithmically to determine compounds with protein interaction activity, and two candidates were identified. In general, such methods may hold important opportunities for off-label use of existing approved drugs.

## History

In 1977, Kenneth S. Warren, an American researcher, invented the concept of what is now "neglected tropical diseases".[166] In 2005 Lorenzo Savioli, a senior United Nations civil servant, was appointed director of the "Department of Control of Neglected Tropical Diseases".[167]

The World Health Organization definition of neglected tropical disease has been criticised to be restrictive and described as a form of epistemic injustice.[168][89]

## See also

* Contagious disease
* Fecal–oral route transmission
* Neglected Tropical Disease Research and Development
* Drugs for Neglected Diseases Initiative
* Eradication of infectious diseases
* Global Network for Neglected Tropical Diseases
* Orphan diseases

## References

1. ↑ Ritchie, Roser, Mispy, Ortiz-Ospina. "Measuring progress towards the Sustainable Development Goals." SDG-Tracker.org, website (2018).
2. ↑ "What constitutes a neglected tropical disease?". PLOS Neglected Tropical Diseases 14 (1). January 2020. doi:10.1371/journal.pntd.0008001. PMID 31999732.
3. ↑ Yirgu, Robel; Middleton, Jo; Fekadu, Abebaw; Cassell, Jackie A; Tesfaye, Abraham; Jones, Christopher Iain; Bremner, Stephen; Enbiale, Wendemagegn et al. (October 2023). "Scabies in the Amhara region of northern Ethiopia: a cross-sectional study of prevalence, determinants, clinical presentation and community knowledge" (in en). BMJ Open 13 (10). doi:10.1136/bmjopen-2023-075038. ISSN 2044-6055. PMID 37880172.
4. ↑ 4.0 4.1 4.2 "NTDs V.2.0: 'blue marble health' – neglected tropical disease control and elimination in a shifting health policy landscape". PLOS Neglected Tropical Diseases 7 (11). November 2013. doi:10.1371/journal.pntd.0002570. PMID 24278496.
5. ↑ "Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden". PLOS Neglected Tropical Diseases 3 (8). August 2009. doi:10.1371/journal.pntd.0000412. PMID 19707588.
6. ↑ Mike Shanahan (31 January 2006). "Beat neglected diseases to fight HIV, TB and malaria". SciDev.Net. http://www.scidev.net/News/index.cfm?fuseaction=readNews&itemid=2629&language=1.
7. ↑ Silberner, Joanne (12 March 2007). "Making the Case to Fight Schistosomiasis". National Public Radio. https://www.npr.org/templates/story/story.php?storyId=7806977.
8. ↑ "A plan to defeat neglected tropical diseases". Scientific American 302 (1): 90–4, 96. January 2010. doi:10.1038/scientificamerican0110-90. PMID 20063641. Bibcode: 2010SciAm.302a..90H. http://www.scientificamerican.com/article/a-plan-to-defeat-neglected-tropical-diseases/.
9. ↑ "Oral drug therapy for multiple neglected tropical diseases: a systematic review". JAMA 298 (16): 1911–24. October 2007. doi:10.1001/jama.298.16.1911. PMID 17954542.
10. ↑ 10.0 10.1 10.2 10.3 10.4 "Neglected diseases amid wealth in the United States and Europe". Health Affairs 28 (6): 1720–5. 2009-11-01. doi:10.1377/hlthaff.28.6.1720. PMID 19887412. "... the rates of toxocariasis, trichomoniasis, and other neglected infections are approximately the same in the United States as they are in Nigeria.".
11. ↑ "Fighting neglected tropical diseases in the southern United States". BMJ 345. September 2012. doi:10.1136/bmj.e6112. PMID 22977143. http://www.bakerinstitute.org/media/files/Research/6e0a9ec2/HPF-pub-HotezBMJ-091312.pdf.
12. ↑ 12.0 12.1 12.2 ((Control of Neglected Tropical Diseases WHO Team)) (16 January 2023). "Neglected tropical diseases: Q&A" (in en). https://www.who.int/news-room/questions-and-answers/item/neglected-tropical-diseases.
* "The 17 neglected tropical diseases". http://www.who.int/neglected_diseases/diseases/en/.
13. ↑ "DNDi – Best Science for the Most Neglected". http://www.dndi.org/.
14. ↑ "Department of Control of Neglected Tropical Diseases: What we do". https://www.who.int/neglected_diseases/about/en/.
15. ↑ ((GBD 2013 Mortality Causes of Death Collaborators)) (January 2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet 385 (9963): 117–171. doi:10.1016/S0140-6736(14)61682-2. PMID 25530442.
16. ↑ 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 16.12 16.13 16.14 16.15 16.16 16.17 16.18 "The global burden of neglected tropical diseases". Public Health 126 (3): 233–236. March 2012. doi:10.1016/j.puhe.2011.11.015. PMID 22325616.
17. ↑ 17.0 17.1 "The neglected tropical diseases: the ancient afflictions of stigma and poverty and the prospects for their control and elimination". Hot Topics in Infection and Immunity in Children III. Advances in Experimental Medicine and Biology. 582. 2006-01-01. pp. 23–33. doi:10.1007/0-387-33026-7_3. ISBN 978-0-387-31783-0.
18. ↑ 18.00 18.01 18.02 18.03 18.04 18.05 18.06 18.07 18.08 18.09 18.10 18.11 18.12 "Neglected tropical diseases". British Medical Bulletin 93 (1): 179–200. 2010. doi:10.1093/bmb/ldp046. PMID 20007668.
19. ↑ "Bringing neglected tropical diseases into the spotlight". Trends in Parasitology 26 (9): 421–3. September 2010. doi:10.1016/j.pt.2010.06.002. PMID 20591739.
20. ↑ 20.0 20.1 20.2 20.3 20.4 "Stigma and the social burden of neglected tropical diseases". PLOS Neglected Tropical Diseases 2 (5). May 2008. doi:10.1371/journal.pntd.0000237. PMID 18478049.
21. ↑ Moran, Mary (28 October 2014). "Neglected diseases fall outside the market". http://www.ft.com/intl/cms/s/0/07bfe8f2-5e05-11e4-bc04-00144feabdc0.html#axzz3MMnaQdHZ.
22. ↑ 22.0 22.1 "Drug development for neglected diseases: a deficient market and a public-health policy failure". Lancet 359 (9324): 2188–94. June 2002. doi:10.1016/S0140-6736(02)09096-7. PMID 12090998. Bibcode: 2002Lanc..359.2188T.
23. ↑ "The Mectizan Donation Program: 20 years of successful collaboration – a retrospective". Annals of Tropical Medicine and Parasitology 102 (Suppl 1): 7–11. September 2008. doi:10.1179/136485908X337418. PMID 18718147.
24. ↑ Gillis, Justin (25 April 2006). "Cure for Neglected Diseases: Funding". Washington Post. https://www.washingtonpost.com/wp-dyn/content/article/2006/04/24/AR2006042401570.html.
25. ↑ Disease control priorities in developing countries (2nd ed.). Oxford University Press. 2006. ISBN 978-0-8213-6179-5.
26. ↑ 26.0 26.1 "Neglected parasitic infections and poverty in the United States". PLOS Neglected Tropical Diseases 8 (9). September 2014. doi:10.1371/journal.pntd.0003012. PMID 25188455.
27. ↑ 27.0 27.1 27.2 World Health Organization (WHO) (2015): Water Sanitation and Hygiene for accelerating and sustaining progress on Neglected Tropical Diseases. A global strategy 2015–2020 . Geneva, Switzerland, p. 26
28. ↑ "American trypanosomiasis (Chagas' disease)—a tropical disease now in the United States". The New England Journal of Medicine 329 (9): 639–44. August 1993. doi:10.1056/NEJM199308263290909. PMID 8341339.
29. ↑ "CDC – Neglected Tropical Diseases – Diseases". https://www.cdc.gov/globalhealth/ntd/diseases/index.html.
30. ↑ "PLoS Neglected Tropical Diseases: A Peer-Reviewed Open-Access Journal". https://journals.plos.org/plosntds/s/journal-information.
31. ↑ World Health Organization. Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases. 2010.
32. ↑ Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, Sachs JD. "Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria". PLoS Med 2006 Jan;3(5):e102.
33. ↑ 33.0 33.1 33.2 Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, et al. (6 September 2007). "Control of neglected tropical diseases". N Engl J Med 357(10):1018-1027.
34. ↑ 34.0 34.1 "Buruli Ulcer: Fact Sheet No. 199" (in en-GB). February 2016. https://www.who.int/buruli/en/.
35. ↑ 35.0 35.1 "Programmes: Buruli ulcer (Mycobacterium ulcerans infection)". https://www.who.int/buruli/en/.
36. ↑ Johnson, Paul D. R. (2019). "Buruli Ulcer in Australia". Buruli Ulcer: Mycobacterium Ulcerans Disease. Cham, Switzerland: Springer. pp. 61–76. doi:10.1007/978-3-030-11114-4_3. ISBN 978-3-030-11113-7. https://www.ncbi.nlm.nih.gov/books/NBK553830/.
37. ↑ "Buruli Ulcer Endemic Countries". https://www.who.int/buruli/country/en/.
38. ↑ 38.0 38.1 38.2 38.3 38.4 38.5 38.6 "Chagas disease (American trypanosomiasis)". https://www.who.int/neglected_diseases/diseases/chagas/en/.
39. ↑ 39.0 39.1 39.2 39.3 39.4 "World Health Day 2014: small bite, big threat". https://www.who.int/neglected_diseases/en/.
40. ↑ 40.0 40.1 40.2 40.3 40.4 40.5 "Dengue Control". https://www.who.int/denguecontrol/human/en/.
41. ↑ 41.0 41.1 41.2 "Chikungunya, an epidemic arbovirosis". The Lancet. Infectious Diseases 7 (5): 319–27. May 2007. doi:10.1016/S1473-3099(07)70107-X. PMID 17448935. Bibcode: 2007LanID...7..319P.
42. ↑ "Symptoms, Diagnosis, & Treatment | Chikungunya virus | CDC" (in en-us). 2018-12-17. https://www.cdc.gov/chikungunya/symptoms/index.html.
43. ↑ Chikungunya, WHO, https://www.who.int/denguecontrol/arbo-viral/other_arboviral_chikungunya/en/, retrieved 21 January 2016
44. ↑ "View Latest Worldwide Guinea Worm Case Totals". https://www.cartercenter.org/health/guinea_worm/case-totals.html.
45. ↑ "Dracunculiasis eradication – global surveillance summary, 2009". Relevé Épidémiologique Hebdomadaire 85 (19): 166–76. May 2010. PMID 20449943. https://www.who.int/wer/2010/wer8519.pdf.
46. ↑ 46.0 46.1 46.2 46.3 46.4 46.5 "Dracunculiasis". https://www.who.int/dracunculiasis/en/.
47. ↑ "Echinococcosis". https://www.who.int/echinococcosis/en/.
48. ↑ 48.0 48.1 "Transmission of echinococcosis". https://www.who.int/echinococcosis/transmission/en/.
49. ↑ 49.0 49.1 49.2 "Signs, symptoms and treatment of echinococcosis". https://www.who.int/echinococcosis/symptoms/en/.
50. ↑ 50.0 50.1 "Surveillance, prevention and control of echinococcosis". https://www.who.int/echinococcosis/control/en/.
51. ↑ 51.0 51.1 51.2 51.3 51.4 51.5 "Yaws". https://www.who.int/yaws/en/.
52. ↑ "Foodborne trematode infections". World Health Organization. https://www.who.int/foodborne_trematode_infections/infections_more/en/.
53. ↑ "Human African trypanosomiasis: number of new cases drops to historically low level in 50 years". World Health Organization. https://www.who.int/neglected_diseases/integrated_media/integrated_media_hat_june_2010/en/index.html.
54. ↑ 54.0 54.1 "Burden and Distribution". https://www.who.int/leishmaniasis/burden/en/.
55. ↑ "Leishmaniasis". https://www.who.int/leishmaniasis/en/.
56. ↑ "Diagnosis, detection and surveillance". https://www.who.int/leishmaniasis/surveillance/en/.
57. ↑ "Access to essential antileishmanial medicines and treatment". https://www.who.int/leishmaniasis/research/en/.
58. ↑ "Leprosy: New data show steady decline in new cases". 9 September 2019. https://www.who.int/neglected_diseases/news/Leprosy-new-data-show-steady-decline-in-new-cases/en/.
59. ↑ 59.0 59.1 "Leprosy Today". https://www.who.int/lep/en/.
60. ↑ 60.0 60.1 "Leprosy: the disease". https://www.who.int/lep/leprosy/en/.
61. ↑ 61.0 61.1 "Leprosy". 10 September 2019. https://www.who.int/en/news-room/fact-sheets/detail/leprosy.
62. ↑ 62.0 62.1 "Epidemiology". https://www.who.int/lymphatic_filariasis/epidemiology/en/.
63. ↑ 63.0 63.1 "Forms of Lymphatic Filariasis and diagnosis". https://www.who.int/lymphatic_filariasis/epidemiology/epidemiology_forms/en/.
64. ↑ 64.0 64.1 "Lymphatic filariasis". https://www.who.int/lymphatic_filariasis/en/.
65. ↑ "Triple co-administration of ivermectin, albendazole and praziquantel in Zanzibar: a safety study". PLOS Neglected Tropical Diseases 2 (1). January 2008. doi:10.1371/journal.pntd.0000171. PMID 18235853.
66. ↑ "Clinical manifestations". https://www.who.int/lymphatic_filariasis/epidemiology/epidemiology_manifestations/en/.
67. ↑ "A case and review of noma". PLOS Neglected Tropical Diseases 4 (12). December 2010. doi:10.1371/journal.pntd.0000869. PMID 21200428.
68. ↑ Johnson, Sarah (2023-12-15). "Survivors of disfiguring condition hail addition to WHO neglected diseases list" (in en-GB). The Guardian. ISSN 0261-3077. https://www.theguardian.com/global-development/2023/dec/15/survivors-of-disfiguring-condition-hail-addition-to-who-neglected-diseases-list.
69. ↑ "Onchocerciasis: Key facts". 11 January 2022. https://www.who.int/en/news-room/fact-sheets/detail/onchocerciasis.
70. ↑ 70.0 70.1 70.2 70.3 "Onchocerciasis: Fact sheet No. 374". February 2013. https://www.who.int/mediacentre/factsheets/fs374/en/.
71. ↑ 71.0 71.1 71.2 "Health topics: Onchocerciasis". https://www.who.int/topics/onchocerciasis/en/.
72. ↑ 72.0 72.1 "Rabies". https://www.who.int/rabies/en/.
73. ↑ 73.0 73.1 73.2 73.3 73.4 "About rabies". https://www.who.int/rabies/about/en/.
74. ↑ 74.0 74.1 "Rabies". https://www.who.int/mediacentre/factsheets/fs099/en/.
75. ↑ "Schistosomiasis-Disease". CDC, Division of Parasitic Diseases. https://www.cdc.gov/parasites/schistosomiasis/disease.html.
76. ↑ Lo, Nathan C.; Heft-Neal, Sam; Coulibaly, Jean T.; Leonard, Leslie; Bendavid, Eran; Addiss, David G. (2019-11-01). "State of deworming coverage and equity in low-income and middle-income countries using household health surveys: a spatiotemporal cross-sectional study" (in English). The Lancet Global Health 7 (11): e1511–e1520. doi:10.1016/S2214-109X(19)30413-9. ISSN 2214-109X. PMID 31558383.
77. ↑ 77.0 77.1 77.2 77.3 77.4 77.5 77.6 77.7 77.8 "Soil-transmitted helminth infections". https://www.who.int/mediacentre/factsheets/fs366/en/.
78. ↑ 78.0 78.1 "Transmission of taeniasis/cysticercosis". https://www.who.int/taeniasis/transmission/en/.
79. ↑ 79.0 79.1 "Taeniasis". U.S. Centers for Disease Control and Prevention. 7 June 2024. https://www.cdc.gov/dpdx/taeniasis/index.html.
80. ↑ 80.0 80.1 80.2 "About Taeniasis/cysticercosis". https://www.who.int/taeniasis/about_disease/en/.
81. ↑ 81.0 81.1 81.2 "Signs, symptoms and treatment of taeniasis/cysticercosis". https://www.who.int/taeniasis/symptoms/en/.
82. ↑ "Taenia saginata as a cause of bowel obstruction". ACG Case Reports Journal 5. 2018. doi:10.14309/crj.2018.37. PMID 29850644.
83. ↑ "Surveillance, prevention and control of taeniasis/cysticercosis". https://www.who.int/taeniasis/control/en/.
84. ↑ 84.0 84.1 84.2 84.3 84.4 "Priority eye diseases". https://www.who.int/blindness/causes/priority/en/index2.html.
85. ↑ Zerbato, Verena; Di Bella, Stefano; Pol, Riccardo; D'Aleo, Francesco; Angheben, Andrea; Farina, Claudio; Conte, Marco; Luzzaro, Francesco et al. (2023). "Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update" (in en). Mycopathologia 188 (4): 307–334. doi:10.1007/s11046-023-00735-z. ISSN 0301-486X. PMID 37294504.
86. ↑ 86.0 86.1 "Snakebite finally makes a WHO list of top global health priorities". 12 June 2017. https://www.statnews.com/2017/06/12/snakebite-who-priority/.
87. ↑ Gutiérrez, JM; Calvete, JJ; Habib, AG; Harrison, RA; Williams, DJ; Warrell, DA (14 September 2017). "Snakebite envenoming.". Nature Reviews. Disease Primers 3. doi:10.1038/nrdp.2017.63. PMID 28905944.
88. ↑ "The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths". PLOS Medicine 5 (11). November 2008. doi:10.1371/journal.pmed.0050218. PMID 18986210.
89. ↑ 89.0 89.1 Bhaumik, Soumyadeep; Zwi, Anthony B.; Norton, Robyn; Jagnoor, Jagnoor (2023-08-01). "How and why snakebite became a global health priority: a policy analysis" (in en). BMJ Global Health 8 (8). doi:10.1136/bmjgh-2023-011923. ISSN 2059-7908. PMID 37604596. PMC 10445399. https://gh.bmj.com/content/8/8/e011923.
90. ↑ 90.0 90.1 "Neglected tropical diseases and mental health: a perspective on comorbidity". Trends in Parasitology 28 (5): 195–201. May 2012. doi:10.1016/j.pt.2012.03.001. PMID 22475459.
91. ↑ 91.0 91.1 Bhaumik, Soumyadeep; Kallakuri, Sudha; Kaur, Amanpreet; Devarapalli, Siddhardha; Daniel, Mercian (2020-11-01). "Mental health conditions after snakebite: a scoping review" (in en). BMJ Global Health 5 (11). doi:10.1136/bmjgh-2020-004131. ISSN 2059-7908. PMID 33257419. PMC 7705584. https://gh.bmj.com/content/5/11/e004131.
92. ↑ "Neglected tropical diseases: infection, modeling, and control". Journal of Health Care for the Poor and Underserved 21 (1): 53–69. February 2010. doi:10.1353/hpu.0.0270. PMID 20173255.
93. ↑ "Exploring gender dimensions of treatment programmes for neglected tropical diseases in Uganda". PLOS Neglected Tropical Diseases 7 (7). 2013. doi:10.1371/journal.pntd.0002312. PMID 23875047.
94. ↑ 94.0 94.1 "Socioeconomic aspects of neglected tropical diseases". Lancet 375 (9710): 239–47. January 2010. doi:10.1016/S0140-6736(09)61422-7. PMID 20109925.
95. ↑ "'Neglected' diseases but unrecognised successes—challenges and opportunities for infectious disease control". Lancet 364 (9431): 380–3. 2004. doi:10.1016/S0140-6736(04)16728-7. PMID 15276399.
96. ↑ "Diagnosing Neglected Tropical Diseases in HIV Coinfection". Human Parasitic Diseases 2015 (7): 11–18. 2015-08-23. doi:10.4137/HPD.S19569. http://www.la-press.com/diagnosing-neglected-tropical-diseases-in-hiv-coinfection-article-a5015.
97. ↑ 97.0 97.1 97.2 97.3 "Interlocked Infections: The Health Burdens of Syndemics of Neglected Tropical Diseases". Annals of Anthropological Practice 36 (2): 328–345. November 2012. doi:10.1111/napa.12007.
98. ↑ "Which new approaches to tackling neglected tropical diseases show promise?". PLOS Medicine 7 (5). May 2010. doi:10.1371/journal.pmed.1000255. PMID 20502599.
99. ↑ United Nations (2017) Resolution adopted by the General Assembly on 6 July 2017, Work of the Statistical Commission pertaining to the 2030 Agenda for Sustainable Development (A/RES/71/313)
100. ↑ World Health Organization (WHO) (2012). Accelerating work to overcome the global impact of Neglected Tropical Diseases. A roadmap for implementation . Geneva, Switzerland.
101. ↑ "The NTD road map: together towards 2030" (in en). https://www.who.int/teams/control-of-neglected-tropical-diseases.
102. ↑ 102.0 102.1 ((Department of Control of Neglected Tropical Diseases)) (2023). Global report on neglected tropical diseases 2023. Geneva: World Health Organization. ISBN 978-92-4-006729-5. https://www.who.int/publications/i/item/9789240067295.
103. ↑ "FDA Approves Coartem Tablets to Treat Malaria". USFDA. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149559.htm.
104. ↑ "Developing drugs for developing countries". Health Affairs 25 (2): 313–24. 2006. doi:10.1377/hlthaff.25.2.313. PMID 16522573.
105. ↑ 105.0 105.1 Taylor-Robinson, David C.; Maayan, Nicola; Donegan, Sarah; Chaplin, Marty; Garner, Paul (11 September 2019). "Public health deworming programmes for soil-transmitted helminths in children living in endemic areas". The Cochrane Database of Systematic Reviews 9 (11). doi:10.1002/14651858.CD000371.pub7. ISSN 1469-493X. PMID 31508807.
106. ↑ "The evidence for school-based deworming". http://www.dewormtheworld.org/why-deworm/the-evidence-for-school-based-deworming.
107. ↑ 107.0 107.1 "Deworming and Adjuvant Interventions for Improving the Developmental Health and Well-being of Children in Low- and Middle-income Countries: A Systematic Review and Network Meta-analysis". Campbell Systematic Reviews 12: 1–383. 2016. doi:10.4073/csr.2016.7. https://campbellcollaboration.org/media/k2/attachments/0251_IDCG_Welch_Deworming_review-update.pdf.
108. ↑ "Worms at Work: Long-Run Impacts of a Child Health investment". http://scholar.harvard.edu/kremer/publications/worms-work-long-run-impacts-child-health-investment-0.
109. ↑ "Projected benefits from integrating NTD programs in sub-Saharan Africa". Trends in Parasitology 22 (7): 285–91. July 2006. doi:10.1016/j.pt.2006.05.007. PMID 16730230.
110. ↑ 110.0 110.1 "Malaria and lymphatic filariasis: the case for integrated vector management". The Lancet. Infectious Diseases 13 (1): 89–94. January 2013. doi:10.1016/S1473-3099(12)70148-2. PMID 23084831.
111. ↑ 111.0 111.1 111.2 111.3 "Challenges and opportunities associated with neglected tropical disease and water, sanitation and hygiene intersectoral integration programs". BMC Public Health 15 (1). June 2015. doi:10.1186/s12889-015-1838-7. PMID 26062691.
112. ↑ "WHO strengthens focus on water, sanitation, and hygiene to accelerate elimination of neglected tropical diseases". World Health Organization (WHO). 27 August 2015. https://www.who.int/water_sanitation_health/events/wash-and-ntd-strategy/en/.
113. ↑ "Collaboration between WASH and NTD". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index9.html.
114. ↑ "NTDs and access to water and sanitation are major global challenges". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/.
115. ↑ "Facial cleanliness and environmental improvement are key to eliminating trachoma". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index2.html.
116. ↑ "Sanitation prevents soil transmitted helminth infections". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index3.html.
117. ↑ "Breeding sites for mosquitoes are reduced through improved sanitation and water management". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index4.html.
118. ↑ "Protecting freshwater from contamination reduces schistosomiasis". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index5.html.
119. ↑ "Safe water is essential to treat and care for NTDs". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index6.html.
120. ↑ "WASH improves the quality of life for people affected by NTDs". World Health Organization (WHO). http://origin.who.int/features/factfiles/wash-ntds/facts/en/index7.html.
121. ↑ "The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis". PLOS Neglected Tropical Diseases 8 (12). December 2014. doi:10.1371/journal.pntd.0003296. PMID 25474705.
122. ↑ "Effect of water, sanitation, and hygiene on the prevention of trachoma: a systematic review and meta-analysis". PLOS Medicine 11 (2). February 2014. doi:10.1371/journal.pmed.1001605. PMID 24586120.
123. ↑ "Water, sanitation, hygiene, and soil-transmitted helminth infection: a systematic review and meta-analysis". PLOS Medicine 11 (3). March 2014. doi:10.1371/journal.pmed.1001620. PMID 24667810.
124. ↑ "Water, Sanitation, and Hygiene (WASH): a critical component for sustainable soil-transmitted helminth and schistosomiasis control". PLOS Neglected Tropical Diseases 8 (4). April 2014. doi:10.1371/journal.pntd.0002651. PMID 24722335.
125. ↑ "A business plan to help the 'global South' in its fight against neglected diseases". Health Affairs 28 (6): 1760–73. 2009. doi:10.1377/hlthaff.28.6.1760. PMID 19887417. http://siteresources.worldbank.org/EDUCATION/Resources/278200-1099079877269/547664-1099079975330/Peter_Singer_Neglected_Tropical_Diseases.pdf.
126. ↑ "Elimination and eradication of neglected tropical diseases with mass drug administrations: a survey of experts". PLOS Neglected Tropical Diseases 7 (12). 2013. doi:10.1371/journal.pntd.0002562. PMID 24340111.
127. ↑ Burns, Melinda (3 October 2010). "Lifesaving Drug Praziquantel Too Expensive for Africa". Pacific Standard. The Miller-McCune Center for Research, Media and Public Policy. https://psmag.com/social-justice/lifesaving-drug-praziquantel-too-expensive-for-africa-23538.
128. ↑ "Giving What We Can; recommended interventions". http://www.givingwhatwecan.org/where-to-give/recommended-charities#sci.
129. ↑ "Public-private partnership: from there to here". Transactions of the Royal Society of Tropical Medicine and Hygiene 99 (Suppl 1): S9-14. October 2005. doi:10.1016/j.trstmh.2005.06.008. PMID 16087204.
130. ↑ "An Innovative Approach to R&D for Neglected Patients: Ten Years of Experience and Lessons Learned by DNDi". DNDi. January 2014
131. ↑ "About Us | Sabin". http://www.sabin.org/content/about-us.
132. ↑ "Why NTDs? | End7". http://www.end7.org/why-ntds.
133. ↑ "WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships". International Journal for Parasitology: Drugs and Drug Resistance 4 (3): 220–5. December 2014. doi:10.1016/j.ijpddr.2014.09.002. PMID 25516832.
134. ↑ "WIPO Re:Search". http://www.wipo.int/research/en/.
135. ↑ 135.0 135.1 "Japan in pioneering partnership to fund global health research", by Andrew Jack, Financial Times, 30 May 2013
136. ↑ "An Audience with … Tachi Yamada", by Asher Mullard, Nature magazine, September 2013, Volume 12, p.658
137. ↑ "Joining the Fight Against Neglected Diseases", Science magazine, 7 June 2013, Volume 340, p.1148
138. ↑ WHO (3 February 2012). "WHO roadmap inspires unprecedented support to defeat neglected tropical diseases". World Health Organization, Geneva. https://www.who.int/neglected_diseases/London_meeting_follow_up/en/.
139. ↑ Uniting to Combat NTDs (2012). "Endorsements (endorsing organizations)". unitingtocombatntds.org. Uniting to Combat Neglected Tropical Diseases. http://www.unitingtocombatntds.org/endorsements.
140. ↑ The Lancet (2022-01-29). "Neglected tropical diseases: ending the neglect of populations". Lancet 399 (10323): 411. doi:10.1016/S0140-6736(22)00161-1. PMID 35093213.
141. ↑ Elphick-Pooley, Thoko; Engels, Dirk; Uniting to Combat NTDs (2022-01-28). "World NTD Day 2022 and a new Kigali Declaration to galvanise commitment to end neglected tropical diseases". Infectious Diseases of Poverty 11 (1): 2. doi:10.1186/s40249-021-00932-2. PMID 35086566.
142. ↑ Mutapi, Francisca (2022-08-29). "A new roadmap for neglected tropical diseases" (in en). Nature. doi:10.1038/d44148-022-00125-5. https://www.nature.com/articles/d44148-022-00125-5.
143. ↑ Burki, Talha (2022-07-02). "New declaration on neglected tropical diseases endorsed". Lancet 400 (10345): 15. doi:10.1016/S0140-6736(22)01237-5. PMID 35780782.
144. ↑ "Commonwealth leaders recommit to ending malaria and neglected tropical diseases" (in en). 2022-06-23. https://www.who.int/news/item/23-06-2022-commonwealth-leaders-recommit-to-ending-malaria-and-neglected-tropical-diseases.
145. ↑ "Ken Warren and the Rockefeller Foundation's great neglected diseases network, 1978–1988: the transformation of tropical and global medicine". Molecular Medicine 20 (Suppl 1): S24-30. December 2014. doi:10.2119/molmed.2014.00221. PMID 25549230.
146. ↑ 146.0 146.1 146.2 "Organization of oversight for integrated control of neglected tropical diseases within Ministries of Health". PLOS Neglected Tropical Diseases 12 (11). November 2018. doi:10.1371/journal.pntd.0006929. PMID 30462639.
147. ↑ 147.0 147.1 "The burden of Neglected Tropical Diseases in Brazil, 1990–2016: A subnational analysis from the Global Burden of Disease Study 2016". PLOS Neglected Tropical Diseases 12 (6). June 2018. doi:10.1371/journal.pntd.0006559. PMID 29864133.
148. ↑ 148.0 148.1 "Challenges in modeling complexity of neglected tropical diseases: a review of dynamics of visceral leishmaniasis in resource limited settings". Emerging Themes in Epidemiology 14 (1). December 2017. doi:10.1186/s12982-017-0065-3. PMID 28936226.
149. ↑ "Measuring the burden of neglected tropical diseases: the global burden of disease framework". PLOS Neglected Tropical Diseases 1 (2). November 2007. doi:10.1371/journal.pntd.0000114. PMID 18060077.
150. ↑ "Asymmetries of poverty: why global burden of disease valuations underestimate the burden of neglected tropical diseases". PLOS Neglected Tropical Diseases 2 (3). March 2008. doi:10.1371/journal.pntd.0000209. PMID 18365036.
151. ↑ 151.0 151.1 Forget, Patrice (2016-10-14). "Faculty of 1000 evaluation for Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015.". Faculty Opinions. doi:10.3410/f.726827339.793524296.
152. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Y`
153. ↑ 153.0 153.1 153.2 Cite error: Invalid `<ref>` tag; no text was provided for refs named `E`
154. ↑ G-FINDER Database http://www.georgeinstitute.org/about-us/media-centre/g-finder-database-open-public
155. ↑ Adams CP, Brantner VV. "Estimating the cost of new drug development: is it really 802 million dollars?" Health Aff (Millwood). 2006 Mar-Apr;25(2):420-8.
156. ↑ DiMasi JA, Hansen RW, Grabowski HG. "The price of innovation: new estimates of drug development costs". J Health Econ. 2003 Mar;22(2):151-85.
157. ↑ 157.0 157.1 Cite error: Invalid `<ref>` tag; no text was provided for refs named `Z`
158. ↑ 158.0 158.1 Bethony JM, Cole RN, Guo X, Kamhawi S, Lightowlers MW, Loukas A, et al. "Vaccines to combat the neglected tropical diseases". Immunol Rev 2011 Jan;239(1):237-270.
159. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Z2`
160. ↑ Tchuem Tchuente LA. "Control of soil-transmitted helminths in sub-Saharan Africa: Diagnosis, drug efficacy concerns and challenges". Acta Trop 2010 Jul 21.
161. ↑ Smits HL. "Prospects for the control of neglected tropical diseases by mass drug administration". Expert Rev Anti Infect Ther 2009 Feb;7(1):37-56.
162. ↑ Renslo AR, McKerrow JH. (December 2006). "Drug discovery and development for neglected parasitic diseases". Nat Chem Biol. 2(12):701-710.
163. ↑ Kesselheim AS. "Drug development for neglected diseases – the trouble with FDA review vouchers". New England Journal of Medicine 2008 Nov 6;359(19):1981–1983.
164. ↑ Kar S. (2010) "Opinion – Open innovation: an answer for neglected diseases." Future Med ChemSep;2(9):1411–1415.
165. ↑ Ortí L, Carbajo RJ, Pieper U, Eswar N, Maurer SM, Rai AK, Taylor G, Todd MH, Pineda-Lucena A, Sali A, Marti-Renom MA. "A kernel for open source drug discovery in tropical diseases." PLoS Negl Trop Dis 2009;3(4):e418.
166. ↑ "Ken Warren and the Rockefeller Foundation's great neglected diseases network, 1978–1988: the transformation of tropical and global medicine". Molecular Medicine 20 (Suppl 1): S24-30. December 2014. doi:10.2119/molmed.2014.00221. PMID 25549230.
167. ↑ "WHO | Dr. Lorenzo Savioli". http://www.who.int/neglected_diseases/director/en/index.html.
168. ↑ Bhaumik, Soumyadeep (2024-12-31). "On the nature and structure of epistemic injustice in the neglected tropical disease knowledge ecosystem" (in en). PLOS Neglected Tropical Diseases 18 (12). doi:10.1371/journal.pntd.0012781. ISSN 1935-2735. PMID 39739949.

## External links

* WHO – Control of neglected tropical disease
* PLOS Neglected Tropical Diseases
* United Nations World Health Organization
* U.S. Food and Drug Administration
* India's neglected tropical diseases
* Neglected tropical disease targets must include morbidity
* Global health policy and neglected tropical diseases: Then, now, and in the years to come
* UK's One Health Vector-Borne Diseases Hub

Classification|

* ICD-10: Xxx.x
* ICD-9-CM: xxx

|

* v
* t
* e

Diseases of poverty

Diseases of poverty|

* AIDS
* Malaria
* Tuberculosis
* Measles
* Pneumonia
* Diarrheal diseases
* Plague

Neglected diseases|

* Cholera
* Chagas disease
* African sleeping sickness
* Schistosomiasis
* Dracunculiasis
* River blindness
* Leishmaniasis
* Trachoma

Miscellaneous|

* Malnutrition
* Priority review voucher

* v
* t
* e

Effective altruism

Concepts|

* Charity assessment
* Demandingness objection
* Disability-adjusted life year
* Earning to give
* Equal consideration of interests
* Marginal utility
* Quality-adjusted life year
* Utilitarianism
* Venture philanthropy

Key figures|

* Liv Boeree
* Nick Bostrom
* Hilary Greaves
* Holden Karnofsky
* William MacAskill
* Dustin Moskovitz
* Yew-Kwang Ng
* Toby Ord
* Derek Parfit
* Peter Singer
* Eliezer Yudkowsky

Organizations|

* 80,000 Hours
* Animal Charity Evaluators
* Animal Ethics
* Against Malaria Foundation
* Center for High Impact Philanthropy
* Centre for the Study of Existential Risk
* Deworm the World Initiative
* Faunalytics
* Future of Humanity Institute
* Future of Life Institute
* Founders Pledge
* GiveDirectly
* GiveWell
* Giving What We Can
* Good Ventures
* The Good Food Institute
* The Humane League
* Mercy for Animals
* Machine Intelligence Research Institute
* Malaria Consortium
* Open Philanthropy Project
* Raising for Effective Giving
* Schistosomiasis Control Initiative
* Sentience Institute

Focus areas|

* Aid effectiveness
* Biotechnology risk
* Climate change
* Cultured meat
* Disease burden
* Economic stability
* Existential risk from artificial general intelligence
* Global catastrophic risk
* Global health
* Global poverty
* Immigration reform
* Intensive animal farming
* Land use reform
* Life extension
* Malaria prevention
* Mass deworming
* Neglected tropical diseases
* Wild animal suffering

Literature|

* Doing Good Better
* The End of Animal Farming
* Famine, Affluence, and Morality
* The Life You Can Save
* Living High and Letting Die
* The Most Good You Can Do
* Practical Ethics
* The Precipice

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Neglected tropical diseases. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Medicine:Neglected_tropical_diseases&oldid=4578075"
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template