Noora (vaccine)

Short description: Vaccine candidate against COVID-19

Noora (vaccine)Vaccine description

Target disease| SARS-CoV-2
Type| Protein subunit
Clinical data
Routes of
administration| Intramuscular

Noora (Persian: نورا) is a COVID-19 vaccine candidate developed by Baqiyatallah University of Medical Sciences in collaboration with Plasma Darman Sarv Sepid Co. (lit. White Cypress Plasma Treatment) in Iran.[1][2]

## Contents

* 1 Medical uses
* 2 Pharmacology
* 3 Manufacturing
* 4 Clinical trials
* 5 See also
* 6 References

## Medical uses

It requires three doses given by intramuscular injection on days 0, 21 and 35.[3]

## Pharmacology

Noora is a recombinant RBD protein subunit vaccine.[3]

## Manufacturing

Up to 8 December 2021, 5 millions doses have been produced.[4]

## Clinical trials

Clinical trials of Noora  Phase  | Registration number  | Start  | Number of participants  | Age of participants  | Ref

|
|
|
|
|

Total  | Vaccine  | Placebo
I | IRCT20210620051639N1 | 25 June 2021  | 70 | 30 (80 µg)

30 (120 µg)

| 10 (placebo) | 18–50 years  | [3]
II | IRCT20210620051639N2 | 10 October 2021  | 300 | 240  | 60  | 18–40 years  | [5]
III | IRCT20210620051639N3 | 23 December 2021  | 10000 |  |  | >18 years  | [6]

## See also

* Pharmaceuticals in Iran
* COVID-19 pandemic in Iran
* COVID-19 vaccine clinical research

## References

1. ↑ "IRGC starts clinical trial of "Noora" coronavirus vaccine". Tehran Times. 27 June 2021. https://www.tehrantimes.com/news/462470/IRGC-starts-clinical-trial-of-Noora-coronavirus-vaccine.
2. ↑ "IRGC Commander: Iran-Made 'Noora' Coronavirus Vaccine Ready for 2nd Stage of Human Trial". Fars News Agency. 22 August 2021. https://www.farsnews.ir/en/news/14000531000599/IRGC-Cmmander-Iran-Made-‘Nra’-Crnavirs-Vaccine-Ready-fr-2nd-Sage-f.
3. ↑ 3.0 3.1 3.2 "A randomized, double-blinded, placebo-controlled phase I clinical trial to evaluate the safety and immunogenicity of three dose regimens of COVID-19 RBD protein recombinant vaccine (AmitisGen; 80µg and 120µg) in a healthy population". Iranian Clinical Trials Registry. 25 June 2021. IRCT20210620051639N1. Retrieved 1 July 2021.
4. ↑ "5 میلیون دوز واکسن "نورا" تولید شد- اخبار پزشکی - اخبار اجتماعی تسنیم | Tasnim" (in fa). https://www.tasnimnews.com/fa/news/1400/09/17/2622286/5-میلیون-دوز-واکسن-نورا-تولید-شد.
5. ↑ "IRCT | A double-blind, randomized, placebo-controlled Phase II clinical trial to evaluate the immunogenicity and safety of covid-19 recombinant RBD protein vaccine (80 microgram) of Plasma Darman Sarve Sepid Co. in healthy population.". https://en.irct.ir/trial/59156.
6. ↑ "IRCT |Phase 3 Clinical Trial to evaluate the Immunogenicity and Safety of Covid19 Recombinant RBD Protein Vaccine (Noora Vaccine) as a Booster Vaccine after injection of existing Vaccines in IRAN". https://en.irct.ir/trial/60796.

* v
* t
* e

Artificial induction of immunity / Immunization: Vaccines, Vaccination, Infection, Biology:Inoculat, Inoculation (J07)

Development|

* Adjuvants
* List of vaccine ingredients
* Mathematical modelling
* Timeline
* Trials

Classes|

* Conjugate vaccine
* DNA vaccination
* Inactivated vaccine
* Live vector vaccine
* Attenuated vaccine
* Heterologous vaccine
* Subunit/component / Peptide / Virus-like particle
* Toxoid

Administration|

* Global:
* GAVI Alliance
* Policy
* Schedule
* Vaccine injury
* USA:
* ACIP
* Vaccine court
* Vaccines for Children Program
* VAERS
* VSD

Vaccines|

| Bacterial|

* Anthrax
* Brucellosis
* Cholera#
* Diphtheria#
* Hib#
* Leptospirosis
* Lyme disease‡
* Meningococcus#
* MeNZB
* Medicine:NmVac4-A/C/Y/W-135
* Pertussis#
* Plague
* Pneumococcal#
* PCV
* PPSV
* Q fever
* Tetanus#
* Tuberculosis
* BCG#
* Typhoid#
* Ty21a
* ViCPS
* Typhus
* combination: DTwP/DTaP

|

Viral|

* Adenovirus
* Flu#
* H1N1 (Pandemrix)
* LAIV
* Hantavirus
* Hepatitis A#
* Hepatitis B#
* Hepatitis E
* HPV
* Cervarix
* Gardasil
* Japanese encephalitis#
* Measles#
* Mumps#
* Medicine:Mumpsvax
* Polio#
* Sabin
* Salk
* Rabies#
* Rotavirus#
* Rubella#
* Smallpox
* Medicine:Dryvax
* Tick-borne encephalitis
* Varicella zoster
* chicken pox#
* Zoster vaccine
* Yellow fever#
* combination:
* MMR
* MMRV
* research:
* Chikungunya
* Cytomegalovirus
* Dengue
* Ebola
* Epstein–Barr virus
* Hepatitis C
* HIV

Protozoan|

* Malaria
* RTS,S
* research:
* Trypanosomiasis

Helminthiasis|

* research:
* Hookworm
* Schistosomiasis

Other|

* Androvax (androstenedione albumin)
* Cancer vaccines
* ALVAC-CEA
* BCG#
* Hepatitis B#
* HPV
* Cervarix
* Gardasil
* PROSTVAC
* NicVAX
* Ovandrotone albumin (Fecundin)
* TA-CD
* TA-NIC
* combination
* DTaP-IPV/Hib
* DTaP-IPV-HepB
* Hexavalent vaccine
* Pentavalent vaccine

Controversy|

* General
* MMR
* NCVIA
* Pox party
* Thiomersal
* Vaccines and SIDS
* Lancet MMR autism fraud
* Cedillo v. Secretary of Health and Human Services
* Alternative vaccination schedule

Related|

* Epidemiology
* Eradication of infectious diseases
* Every Child by Two
* List of vaccine topics

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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