Parental obesity

Maternal obesity refers to obesity (often including being overweight) of a woman during pregnancy. Parental obesity refers to obesity of either parent during pregnancy. Maternal obesity has a significant impact on maternal metabolism and offspring development.[1] Insulin resistance, glucose homeostasis, fat oxidation and amino acid synthesis are all disrupted by maternal obesity and contribute to adverse outcomes.[1] Modification of lifestyle is an effective intervention strategy for improvement of maternal metabolism and the prevention of adverse outcomes.[1]

Obesity is defined as having a Body Mass Index (BMI) of 30 or greater. A 5-foot-5-inch tall woman would be considered obese if she weighs 180 pounds or more and a 5-foot-8-inch tall woman would be considered obese if she weighs 200 pounds or more.[2]

## Contents

* 1 Effects on the fetus
* 1.1 Defects/ impairments
* 1.2 Mental or physical effects on the fetus
* 1.3 Paternal obesity effects on the fetus
* 2 Obesity effects on the mother
* 2.1 Disease
* 2.2 Effects of negative diets
* 3 Modifying the risks
* 4 Nutrition recommendations
* 5 Exercise recommendations
* 6 References

## Effects on the fetus

### Defects/ impairments

Between 18 and 38% of pregnant women of American women are classified as obese. However, little is known about the link between maternal obesity and diabetic effects in offspring. Maternal obesity is associated with increased odds of pregnancies affected by congenital anomalies, including neural tube defects and spina bifida.[3] The chances of having neural tube defects in the newborn of an obese woman has been shown to be twice that of a non-obese pregnant female.[2] Some other anomalies that were increased among mothers with obesity included septal anomalies, cleft palate, cleft lip and palate, anorectal atresia, hydrocephaly, and limb reduction anomalies. Babies are also more likely to be admitted to neonatal intensive care units because of effects from the obese mother. Each year, nearly 2,500 babies are born[where?] with these defects, and many other affected pregnancies end in miscarriage and stillbirth.[3]

### Mental or physical effects on the fetus

Maternal obesity is linked with elective preterm delivery, neonatal death, and delivery of an extremely low birth weight infant. In follow-up studies of babies whose birth weights were below 1000g, it was shown that 40% to 45% of the survivors had severe neurodevelopmental impairments.[4]

It has been demonstrated through a study on rats that when a pregnant mother ate a diet rich in fat, sugar, and salt, that mother's offspring was more likely to overeat and have a preference for junk food. Even when the offspring were not given the option of junk food, their bodies metabolized food differently from offspring whose mother ate healthier. Offspring of mothers who ate badly had higher levels of cholesterol and triglycerides in their bloodstream and higher risk of heart disease. In addition, these offspring had higher levels of glucose and insulin, which indicate development of type 2 diabetes. The rats were studied through adulthood and were found to be fatter than the offspring whose mothers ate healthier. This study showed that the diet of mothers not only affects the offspring's chemical physiology but also their likelihood of becoming even more unhealthy through their natural preference to bad habits.[5]

### Paternal obesity effects on the fetus

Researchers from the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducted a study and found that early-onset paternal obesity is connected with an increased risk of liver disease in their kin. Researchers found that obese fathers had an elevated level of serum alanine aminotransferase (ALT), a liver enzyme, compared to fathers who were not obese. They did a secondary analysis that excluded obese offspring. Children who were a normal weight but had obese fathers still had elevated ALT levels, which indicated that a child's ALT levels are not dependent upon the child's own BMI.[6]

## Obesity effects on the mother

### Disease

Obese women have an increased risk of pregnancy-related complications, including hypertension, gestational diabetes, and blood clots. Also, the mother is at risk of going into preterm labor.[7][2] Maternal obesity is also known to be associated with increased rates of complications in late pregnancy such as cesarean delivery, and shoulder dystocia.[4] A meta-analysis estimated that Cesarean delivery rates increased with odds ratios of 1.5 among overweight, 2 among obese, and 3 among severely obese women, compared with normal weight pregnant women.[8] In addition, morbidly obese women who have not had children before are at increased risk of all–cause preterm deliveries. It is well recognized that obese women are at increased risk of preeclampsia and that women who have never been pregnant are at higher risk of preeclampsia than women who have had children in the past.[4] Obesity in pregnancy is also known to be associated with hyperinsulinemia, dyslipidemia, impaired endothelial function, and up-regulated markers of inflammation.[9][10][11]

### Effects of negative diets

Poor glycemic control can lead to neural tube defects. The usual increase in insulin resistance seen in late pregnancy is enhanced in obese mothers, causing a postprandial increase in glucose, lipids, and amino acids, as well as excessive fetal exposure to fuel sources.[clarification needed][citation needed] This, in turn, increases fetal size, fat storage, and potential risk for disease. For mothers, impaired glucose tolerance and hyperlipidemia are more common among obese mothers.

## Modifying the risks

There are many options available in treating obesity, such as: altering one's diet and exercising regularly. Moderate forms of exercise, such as walking, can lead to healthy weight loss. Some people who are obese turn to gastric bypass surgery in order to reduce their appetites. It is always advised to consult a physician regarding any obesity treatment.

It is recommended that obese women should try to lose weight before becoming pregnant, yet women should not diet during pregnancy because sufficient nutrition is important for pregnant women and women planning pregnancy. Women with gastric banding can have normal pregnancies and better outcomes than women who do not have the surgery, but in most cases, doctors have agreed that pregnancy should wait until surgery-related weight loss has stabilized. Clinicians have been encouraged to talk to women who are pregnant or may become pregnant about getting enough folic acid, quitting smoking, and avoiding alcohol. Women are also recommended to have appropriate calorie intake and exercise adequately.

## Nutrition recommendations

Pregnant women who ate more sweets, such as candy and processed juices, in early pregnancy were at higher risk of gaining excessive weight. A healthy, well-balanced diet during pregnancy can also help to minimize some pregnancy symptoms such as nausea and constipation.[12]

## Exercise recommendations

During pregnancy, doctors recommend light exercise. Doctors state that exercise can help the comfort of the mother and the well-being of the unborn child. Some benefits include, but are not limited to: reduced back pain, decrease in constipation, less likely to gain excess weight, decreased chance of gestational diabetes, easier labor, quicker recovery, and better physical and emotional health of the baby.[13]

If negative signs and symptoms occur after exercising, pregnant females should stop immediately. Some signs include: dizziness, faintness, headache, shortness of breath, uterine contractions, vaginal bleeding, fluid leaking, or heart palpitations.

## References

1. ↑ 1.0 1.1 1.2 "Maternal metabolism and obesity: modifiable determinants of pregnancy outcome". Human Reproduction Update 16 (3): 255–75. 2010. doi:10.1093/humupd/dmp050. PMID 19966268.
2. ↑ 2.0 2.1 2.2 Boyles, Salynn (3 February 2006). "Obesity Increases Risks in Pregnancy – Moms and Babies Have More Problems". WebMD Health News. http://www.webmd.com/diet/news/20060203/obesity-increases-risks-in-pregnancy.
3. ↑ 3.0 3.1 Goodman, Alice (10 February 2009). "Maternal Obesity Increases Risk for Congenital Anomalies". medscape.com. http://www.medscape.com/viewarticle/588085.
4. ↑ 4.0 4.1 4.2 "Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort study". American Journal of Public Health 97 (1): 157–62. January 2007. doi:10.2105/AJPH.2005.074294. PMID 17138924.
5. ↑ "Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females". The Journal of Physiology 586 (13): 3219–30. July 2008. doi:10.1113/jphysiol.2008.153817. PMID 18467362.
* "Poor Diet During Pregnancy May Have Long Term Impact On Child's Health, Study Suggests". ScienceDaily (Press release). July 1, 2008.
6. ↑ "Early-onset paternal obesity linked to increased risk for liver disease in child". Thaindian News. http://www.thaindian.com/newsportal/health/early-onset-paternal-obesity-linked-to-increased-risk-for-liver-disease-in-child_10033634.html.
7. ↑ Konkel, Lindsey (30 May 2013). "7 Ways Pregnant Women affect babies". http://www.livescience.com/36908-ways-pregnant-women-affect-babies.html.
8. ↑ "Maternal obesity and risk of cesarean delivery: a meta-analysis". Obesity Reviews 8 (5): 385–94. September 2007. doi:10.1111/j.1467-789X.2007.00397.x. PMID 17716296. https://zenodo.org/record/1230641.
9. ↑ "Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways". The Journal of Clinical Endocrinology and Metabolism 87 (9): 4231–7. September 2002. doi:10.1210/jc.2002-020311. PMID 12213876.
10. ↑ "Obesity in pregnancy: prevalence and metabolic consequences". Seminars in Fetal & Neonatal Medicine 15 (2): 70–6. April 2010. doi:10.1016/j.siny.2009.09.006. PMID 19896913.
11. ↑ "Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta". Placenta 29 (3): 274–81. March 2008. doi:10.1016/j.placenta.2007.12.010. PMID 18262644.
12. ↑ "The Pregnant Mother: Exercise During Pregnancy". Ohio State University Medical Center. 2009. http://medicalcenter.osu.edu/patientcare/healthcare_services/pregnancy_childbirth/care/the_pregnant_mother/Pages/index.aspx.
13. ↑ Weiss, Robin Elise. "Pregnant Women Need More Exercise". http://pregnancy.about.com/od/stayinghealthy/a/morepgexercise.htm.

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