Salt-and-pepper chromatin

Well-differentiated neuroendocrine tumor with salt-and-pepper chromatin, seen on H&E stain and Pap stain, and actual salt and pepper for comparison.

In pathology, salt-and-pepper chromatin, also salt-and-pepper nuclei and stippled chromatin, refers to cell nuclei that demonstrate granular chromatin (on light microscopy).[1]

Salt-and-pepper chromatin is typically seen in endocrine tumours such as medullary thyroid carcinoma, neuroendocrine tumours[2] and pheochromocytoma.[3]

## Additional images

* Neuroendocrine tumour of the lung with salt-and-pepper chromatin. H&E stain.

* Neuroendocrine tumour of the small intestine with salt-and-pepper chromatin. H&E stain.

* A pheochromocytoma showing finely granular chromatin. H&E stain.

* Salt-and-pepper chromatin (pheochromocytoma). H&E stain.

## References

1. ↑ "Pancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term "rhabdoid" appropriate?". J. Clin. Pathol. 57 (10): 1106–10. October 2004. doi:10.1136/jcp.2004.018309. PMID 15452172.
2. ↑ "The development and characterization of a human midgut carcinoid cell line". Clin. Cancer Res. 13 (16): 4704–12. August 2007. doi:10.1158/1078-0432.CCR-06-2723. PMID 17699847.
3. ↑ "Pheochromocytoma. Cytologic findings on intraoperative scrape smears in five cases". Acta Cytol. 43 (2): 207–13. 1999. doi:10.1159/000330978. PMID 10097711.

## External links

* Salt-and-pepper chromatin \- nature.com.
* Salt-and-pepper nucleus \- upmc.edu.

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