Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.[citation needed]

Drawn from international guidelines that emerged from the Surviving Sepsis Campaign[1][2] the Sepsis Six was developed by The UK Sepsis Trust.[3] (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably.

In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was associated with a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days.[4] Though the authors urge caution in a causal interpretation of these findings.[citation needed]

The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:[citation needed]

1. Titrate oxygen to a saturation target of 94%
2. Take blood cultures and consider source control
3. Administer empiric intravenous antibiotics
4. Measure serial serum lactates
5. Start intravenous fluid resuscitation
6. Commence accurate urine output measurement.

## References

1. ↑ R. Phillip, Dellinger; Mitchell M., Levy; Jean M., Carlet; Julian, Bion; Margaret M., Parker; Roman, Jaeschke; Konrad, Reinhart; Derek C., Angus et al. (1 January 2008). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn et al.. eds. "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008". Critical Care Medicine (Society of Critical Care Medicine/Lippincott Williams & Wilkins) 36 (1): 296–327. doi:10.1097/01.ccm.0000298158.12101.41. ISSN 0090-3493. OCLC 772657699. PMID 18158437. https://pubmed.ncbi.nlm.nih.gov/18158437/.
2. ↑ Rhodes, Andrew; Evans, Laura E.; Alhazzani, Waleed; Levy, Mitchell M.; Antonelli, Massimo; Ferrer, Ricard; Kumar, Anand; Sevransky, Jonathan E. et al. (1 March 2017). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn et al.. eds. "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016" (in English). Critical Care Medicine (Society of Critical Care Medicine/Lippincott Williams & Wilkins) 45 (3): 486–452. doi:10.1097/CCM.0000000000002255. ISSN 0090-3493. OCLC 772657699. PMID 28098591. https://dx.doi.org/10.1097/CCM.0000000000002255. Retrieved 22 June 2021.
3. ↑ "Home « The UK Sepsis Trust The UK Sepsis Trust". sepsistrust.org. http://sepsistrust.org/. Retrieved 2014-04-22.
4. ↑ Daniels, Ron; Nutbeam, Tim; McNamara, Georgina; Galvin, Clare (2011). Godlee, Fiona; Abbasi, Kamran; Bloom, Theodora et al.. eds. "The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study". Emergency Medicine Journal (London, England , United Kingdom of Great Britain: BMJ Publishing Group Ltd/British Medical Association) 28 (6): 507–512. doi:10.1136/emj.2010.095067. ISSN 1472-0213. OCLC 32595642. PMID 21036796. https://emj.bmj.com/content/28/6/507.

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